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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMelanocyte-stimulating hormone receptor
SpeciesHomo sapiens (Human)
GeneMC1R
SynonymMSH-R
Melanocortin receptor 1
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC1-R
MC1 receptor
DiseaseAtopic dermatitis
Length317
Amino acid sequenceMAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
UniProtQ01726
Protein Data BankN/A
GPCR-HGmod modelQ01726
3D structure modelThis predicted structure model is from GPCR-EXP Q01726.
BioLiPN/A
Therapeutic Target DatabaseT35842
ChEMBLCHEMBL3795
IUPHAR282
DrugBankBE0002447

Known ligands

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Total entries: 1032
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1942D structureCHEMBL2372838C78H111N21O191646.8722 / 22-3.9No
13662D structureCHEMBL596804C30H28FN5O3525.5845 / 14.3No
13692D structureCHEMBL598021C30H28FN5O3525.5845 / 14.3No
13702D structureCHEMBL596602C30H28FN5O3525.5845 / 14.3No
19002D structureCHEMBL181161C37H45ClN10O5745.2826 / 92.0No
33052D structureCHEMBL212976C37H43N5O3605.7834 / 35.0No
39932D structureCHEMBL412174C52H67BrN12O81068.099 / 113.0No
4418642D structureCHEMBL1775057C47H59N13O9950.07110 / 12-0.8No
4418702D structureCHEMBL1775063C47H59N13O9950.07110 / 12-0.8No
4418712D structureCHEMBL1775064C47H59N13O9950.07110 / 12-0.8No
43442D structureCHEMBL384813C51H68IN13O10S21214.2114 / 140.9No
47092D structureCHEMBL2113144C33H37ClN4O2557.1354 / 25.8No
56482D structureCHEMBL405408C55H67N15O9S21146.3614 / 140.7No
59812D structureCHEMBL504349C34H42FN5O4603.7396 / 34.3No
60722D structureCHEMBL213752C34H44N6O3584.7655 / 43.6No
60742D structureCHEMBL210009C34H44N6O3584.7655 / 43.6No
60772D structureCHEMBL213956C34H44N6O3584.7655 / 43.6No
60792D structureCHEMBL210011C34H44N6O3584.7655 / 43.6No
64692D structureCHEMBL8825C29H30N2O3454.573 / 25.6No
65202D structureCHEMBL380855C35H43ClFN5O2620.216 / 24.5No
65552D structureCHEMBL215895C41H47FN8O4734.8777 / 53.4No
66742D structureCHEMBL267360C45H63N12O9S+948.13410 / 90.4No
71412D structureCHEMBL365237C31H43Cl2N5O2588.6185 / 34.3No
75872D structureBDBM82410C34H51N9O11S793.89416 / 8-4.1No
77092D structureCHEMBL381739C42H57N11O7827.9888 / 91.2No
95372D structureCHEMBL1923663C44H54N12O6846.9948 / 101.7No
5173702D structureSCHEMBL8369982C54H73ClN16O101141.7312 / 14-0.8No
101142D structureCHEMBL591026C32H33N5O4551.6475 / 14.1No
101412D structureCHEMBL508501C54H69N15O91072.2411 / 120.9No
101462D structureCHEMBL509582C54H69N15O91072.2411 / 120.9No
103742D structureCID 16151595C77H103N21O151562.819 / 22-0.3No
106762D structureCHEMBL2028953C50H62N14O111035.1313 / 14-0.4No
124022D structureRY-764C34H51FN4O3582.8055 / 25.4No
134052D structureCHEMBL267020C28H31N5O453.593 / 33.5Yes
135272D structureAc-YK[CEHdFRWC]-NH2C60H79N17O13S21310.5218 / 17-3.3No
147342D structureCHEMBL385561C47H59N13O7918.0739 / 100.9No
148692D structureCHEMBL92481C40H46ClN11O5796.337 / 92.2No
155292D structureCHEMBL397580C31H40Cl2FN5O3620.5916 / 24.1No
158962D structureCHEMBL188651C29H39Cl2N5O3S608.6236 / 33.4No
5480602D structureCHEMBL3971054C48H69ClN16O101065.6312 / 15-1.8No
5577282D structureSCHEMBL8371033C48H69ClN16O101065.6312 / 15-1.8No
4648712D structureCHEMBL3600838C56H75N15O91102.3111 / 111.6No
5174062D structureSCHEMBL8371464C48H70FN17O91048.213 / 15-3.2No
5364082D structureCHEMBL3898758C52H65N15O91044.1911 / 13-0.2No
5364112D structureCHEMBL3936714C52H65N15O91044.1911 / 13-0.2No
5364262D structureCHEMBL3965807C35H50N10O8738.8479 / 9-0.6No
175252D structureCHEMBL425591C47H59N13O7918.0739 / 111.9No
187222D structureCHEMBL378837C31H38FN7O3575.6896 / 42.0No
4652692D structureCHEMBL3600835C55H73N15O91088.2911 / 121.5No
199672D structureCHEMBL381503C34H44ClN5O3606.2084 / 35.3No
5364962D structureCHEMBL3911582C45H58N14O8923.04910 / 12-1.0No
215282D structureCID 70693082C93H145N27O201961.3526 / 241.5No
5174392D structureCHEMBL3663361C48H67N17O101042.1713 / 15-3.1No
5174472D structureCHEMBL3667932C50H69N17O111084.2114 / 15-3.2No
230032D structureCHEMBL406891C52H67N15O9S21110.3214 / 14-0.2No
231912D structureCHEMBL467587C28H38Cl2N4O3549.5375 / 25.0No
233082D structureBDBM50389782C96H146N28O252092.431 / 25-3.0No
5174512D structureSCHEMBL8369995C49H70N18O91055.2213 / 15-3.6No
237852D structureCHEMBL2371963C54H68N10O91001.29 / 83.7No
245812D structureCHEMBL2070248C74H114N18O151495.8416 / 174.0No
249662D structureCHEMBL2113280C26H30N6O442.5673 / 42.4Yes
256822D structureCHEMBL449131C36H38FN5O4623.7296 / 24.9No
4662252D structureCHEMBL3600842C56H75N15O91102.3111 / 111.6No
272582D structureCHEMBL2371968C59H76N10O91069.329 / 85.4No
280302D structureCHEMBL366040C37H44ClN9O6746.2667 / 91.5No
5174612D structureSCHEMBL8368801C50H69N17O91052.2112 / 13-2.3No
5174652D structureCHEMBL3646886C48H69N17O101044.1912 / 15-3.9No
5174662D structureUS8846601, 202C48H69N17O101044.1912 / 15-3.9No
290932D structureCHEMBL2113149C35H42ClN5O2600.2045 / 25.2No
5482122D structureCHEMBL3929099C55H75ClN16O101155.7612 / 14-0.3No
5581812D structureSCHEMBL8369075C55H75ClN16O101155.7612 / 14-0.3No
302502D structureCHEMBL2372830C49H69N15O101028.1913 / 14-3.1No
333502D structureCHEMBL448337C36H38FN5O4623.7296 / 25.3No
333842D structureD0I8SJC90H127N25O26S2007.2131 / 27-10.1No
4429732D structureCHEMBL3421680C34H42N12O5698.7898 / 7-0.9No
339972D structureCHEMBL598643C30H29N5O3507.5944 / 14.2No
339982D structureCHEMBL603468C30H29N5O3507.5944 / 14.2No
340012D structureCHEMBL598442C30H29N5O3507.5944 / 14.2No
340572D structureCHEMBL423101C33H35ClN6O2583.1335 / 24.1No
350702D structureCHEMBL234456C54H73N13O101064.2612 / 12-1.1No
361952D structureCHEMBL309213C38H47N11O5737.8668 / 91.5No
363542D structureCHEMBL407098C52H67N15O9S21110.3214 / 14-0.2No
363742D structureCHEMBL214410C35H45FN8O3644.7967 / 42.3No
374222D structureCHEMBL213284C31H37FN6O4576.6736 / 42.3No
5369402D structureCHEMBL3955172C49H72N14O91001.211 / 13-0.3No
5369452D structureCHEMBL3981581C48H64N14O8965.1310 / 120.6No
383792D structureCHEMBL385000C42H49FN8O6780.9028 / 63.2No
390912D structureCHEMBL380437C35H45N5O2567.7784 / 34.3No
397612D structureCHEMBL598616C30H28FN5O3525.5845 / 14.3No
398862D structureCHEMBL598617C30H27F2N5O3543.5756 / 14.4No
402552D structureCHEMBL467586C28H38Cl2N4O3549.5375 / 25.1No
411402D structureCHEMBL393576C30H40Cl2FN5O2592.5816 / 24.4No
418252D structureCHEMBL407809C60H78FN19O13S21356.5219 / 18-1.9No
420572D structureCHEMBL2113139C38H40ClN5O4S698.2797 / 25.1No
421542D structureCHEMBL1923662C42H51N11O5789.9427 / 92.2No
421582D structureCHEMBL431801C42H51N11O5789.9427 / 92.2No
4680922D structureCHEMBL3600840C56H75N15O91102.3111 / 111.6No
429382D structureCHEMBL420581C40H56N10O5756.9538 / 82.8No
438752D structureCHEMBL434966C47H62N10O6863.0777 / 93.9No
443242D structureCHEMBL269353C53H71N13O91034.2310 / 121.9No

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