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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
aa2ar_human N253A aa2ar_human C254A aa2ar_human F257A
aa2ar_human Y271A  [Orientation Restraint] aa2ar_human I274A  [Orientation Restraint] aa2ar_human S277A  [Orientation Restraint]
aa2ar_human S277N  [Orientation Restraint] aa2ar_human S277T  [Orientation Restraint] aa2ar_human H278A  [Orientation Restraint]
aa2ar_human S281T  [Orientation Restraint] aa2ar_human S281A  [Orientation Restraint] ccr5_human R31
grpr_mouse A235 cckar_xenla N67 ednra_human F229
ednra_human V372 nk1r_rat C306 nk1r_rat C307
nk1r_rat L269 nk1r_rat L270 nk1r_rat L308
nk1r_rat A195 nk1r_rat N68 nk1r_rat C199
nk1r_rat H197 nk1r_rat I198 nk1r_rat S169
nk1r_rat T201 nk1r_rat T65 nk1r_rat T67
nk1r_rat Y196 nk1r_rat Y69 nk1r_rat V200
nk1r_rat V202 nk1r_rat V66 nk1r_rat I32
nk1r_rat L34 nk1r_rat V33 vipr1_rat K144
drd3_human L89 drd3_human L347 drd3_human L371
ednra_rat Y81 lshr_rat V368 mshr_human C75
oprk_mouse I228 oprk_mouse A298 oprk_mouse C229
oprk_mouse E297 oprk_mouse L299 oprk_mouse V230
oprd_mouse A298 oprd_mouse L295 oprd_mouse P294
oprd_mouse V296 oprd_mouse V297 oprk_human E297Q
ada2a_pig A398 ada2a_pig N430 ada2a_pig L396
ada2a_pig T397 ada2a_pig V399 oprm_human K211
cxcr4_rat A172 cxcr4_human A175 adrb1_rat V335
ada1a_human V185A  [Orientation Restraint] oprk_rat E297 oprm_rat Q314
oprm_rat K303 adrb1_human K347 adrb2_human E306A
adrb2_human V307A  [Orientation Restraint] adrb2_human L310A  [Orientation Restraint] adrb2_human L311A  [Orientation Restraint]
adrb2_human I314A  [Orientation Restraint] adrb2_human V317A  [Orientation Restraint] adrb2_human L324A  [Orientation Restraint]
crfr1_human H228 cxcr4_human L41 cxcr4_human F40
v1ar_rat A172 aa1r_human R291 aa1r_human N184
aa1r_human E178 aa1r_human I292 aa1r_human M177
aa1r_human M180 aa1r_human F183 aa1r_human F259
aa1r_human Y179 aa1r_human Y182 aa1r_human V181


Reference:

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