Hi,
I want to model an ABC transporter. It occurs as a homodimer and it has two major conformations, inward and outward. I need a model of my sequence in the outward conformation for which there is only one single structure resolved. Hence, I need to specify the structure, which is possible in the standard I-Tasser. However, since it is a homodimer, modeling of single chains goes horribly wrong (it does not take into account the other chain).
Then I checked out the other algorithms you offer and it seems COTH is the one I need, except that COTH does not allow me to select the structure that should be used.
Is there a way to do this? Another algorithm, or install locally?
Thanks Arjen
atenhave@mdp.edu.ar