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Download BioLiP database
To facilitate template-based protein-ligand docking and protein function annotation, all data from the BioLiP database are freely available. You can download them from the links provided below. ( Please DON'T attempt to download all the files at the same time which may result in crash of the network connections.)

  • Redundant set (Complete set of BioLiP before 2013-03-6. Updated subsets are available at the weekly update.)
    Link Description
    Receptor (with original PDB residue numbering) (3.6 G)
    Receptor1 (with residues re-numbered starting from 1) (3.6 G)
    3D structures of PDB chains that interact with at least one biologically relevant small molecule
    Ligand (438 M) 3D structures of biologically relevant ligands
    Annotations (19 M) The annotations for each ligand-protein interaction site (README)


  • Non-redundant set (Ligand-protein interaction sites with binding site residues identity > 90% and receptor sequence identity >90% are removed.)
    Link Description
    Receptor (with original PDB residue numbering) (2.2 G)
    Receptor1 (with residues re-numbered starting from 1) (2.2 G)
    3D structures of PDB chains that interact with at least one biologically relevant small molecule
    Ligand (365 M) 3D structures of biologically relevant ligands
    Annotations (13 M) The annotations for each ligand-protein interaction site (README)


  • Weekly update
    Download the datasets of weekly update

  • Template library for protein function prediction by COACH and COFACTOR
    Download the library

  • Standalone package for protein function prediction by COACH and COFACTOR
    Donwload through the I-TASSER Suite



  • Reference:
    Jianyi Yang, Ambrish Roy and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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