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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	ISOCLOZAPINE
Molecular formula	C18H19ClN4
IUPAC name	8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.1
Synonyms	CHEMBL415300 SCHEMBL140207 1977-08-8 8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine DTXSID40173464 2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine BRN 0763655 MolPort-042-665-648 5H-DIBENZO(b,e)(1,4)DIAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)- CTK4E2258 ZINC25973757 2-Chloro-11-(4-methyl-1-piperazinyl)-5H-benzo(b,e)(1,4)diazepine AC1L279R 2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(isoclozapine) NCGC00386501-01 5H-Dibenzo[b,e][1,4]diazepine,2-chloro-11-(4-methyl-1-piperazinyl)- D0P0IX 2-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine BDBM50010594 LS-60880 [ Show all ]
Inchi Key	APOMSSAGEAOUGO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
PubChem CID	16104
ChEMBL	CHEMBL415300
IUPHAR	N/A
BindingDB	50010594
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
11177	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
11180	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
11181	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
11179	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
11178	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
11183	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
11185	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
11184	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
11182	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460

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