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Name | MK-5046 |
---|---|
Molecular formula | C20H18F6N4O |
IUPAC name | (2S)-1,1,1-trifluoro-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazol-2-yl]propan-2-ol |
Molecular weight | 444.381 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 4.1 |
Synonyms | (2S)-1,1,1-trifluoro-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazol-2-yl]propan-2-ol AKOS025293428 GTPL6170 MK5046 peak 2 1022152-69-7 [ Show all ] |
Inchi Key | UJINBEQCDMOAHM-SFHVURJKSA-N |
Inchi ID | InChI=1S/C20H18F6N4O/c21-19(22,23)17(6-7-17)10-14-12-27-16(29-14)11-18(31,20(24,25)26)13-2-4-15(5-3-13)30-9-1-8-28-30/h1-5,8-9,12,31H,6-7,10-11H2,(H,27,29)/t18-/m0/s1 |
PubChem CID | 49871766 |
ChEMBL | CHEMBL1672354 |
IUPHAR | 6170 |
BindingDB | 50336889 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
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GLASS ID | Name | UniProt | Gene | Species | Length |
---|---|---|---|---|---|
338192 | Bombesin receptor subtype-3 | O54798 | Brs3 | Mus musculus (Mouse) | 399 |
338193 | Bombesin receptor subtype-3 | Q8K418 | Brs3 | Rattus norvegicus (Rat) | 399 |
338194 | Bombesin receptor subtype-3 | P32247 | BRS3 | Homo sapiens (Human) | 399 |
554960 | Gastrin-releasing peptide receptor | P30550 | GRPR | Homo sapiens (Human) | 384 |
554959 | Neuromedin-B receptor | P28336 | NMBR | Homo sapiens (Human) | 390 |
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