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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●COACH ●COFACTOR ●MetaGO ●MUSTER ●CEthreader ●SEGMER ●FG-MD ●ModRefiner ●REMO ●DEMO ●SPRING ●COTH ●Threpp ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●CR-I-TASSER ●GPCR-I-TASSER ●MAGELLAN ●BindProf ●BindProfX ●SSIPe ●ResQ ●IonCom ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

Other GPCR-related resources GPCR-I-TASSER: On-line server for GPCR structure prediction GPCR-HGmod: Structur models of GPCRs in the human genome GPCR-EXP: collection of experimentally solved GPCRs GLASS: GPCR-ligand association database GPCR resources from other laboratories GPCRDB: information system for GPCRss TinyGPAP mutant database GPCR-OKB: oligomerization knowledge base GPCR natural variants database GLIDA: GPCR-ligand database IUPHAR GPCR database gpDB: G proteins and their interactions with GPCRs SEVENS: GPCR genes database GDD: GPCR decoy database Summary of activation changes in GPCR TMs

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11002 entries in GPCR-RD.
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Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data
acm5_human	A147V	acm5_human	G148A	acm5_human	I149T
acm5_human	A147S	acm5_human	M150L	adrb2_human	C125S  [Orientation Restraint]
vipr1_human	H178A	vipr1_human	H178D	vipr1_human	H178K
ada2a_human	C201S  [Orientation Restraint]	ada2a_human	I198C  [Orientation Restraint]	ada2a_human	S199C  [Orientation Restraint]
ada1b_mesau	Y203A	ada1b_mesau	S318A	adrb2_human	S204S  [Orientation Restraint]
adrb2_human	S204A  [Orientation Restraint]	vipr1_rat	V220M	agtr1_human	A104V  [Orientation Restraint]
agtr1_human	S115A  [Orientation Restraint]	agtr1_human	W153A  [Orientation Restraint]	agtr1_human	T260A  [Orientation Restraint]
nk2r_human	M252X  [Orientation Restraint]	ghsr_human	S123A	ghsr_human	Q120H
ghsr_human	H280Q  [Orientation Restraint]	ghsr_human	Y284F  [Orientation Restraint]	ccr5_human	Q280A
mshr_human	V92M	agtra_rat	F261A	vipr1_human	H178R
ada1a_human	S188A  [Orientation Restraint]	ada1a_human	A189S  [Orientation Restraint]	ada1a_human	A189T  [Orientation Restraint]
ada1a_human	S192A  [Orientation Restraint]	ada1a_human	F193L  [Orientation Restraint]	ada1a_human	Y194F  [Orientation Restraint]
5ht2a_rat	W76A	5ht2a_rat	F383A	drd3_human	T368F
drd3_human	T368V	drd3_human	F172A	5ht1b_human	S181A  [Orientation Restraint]
5ht1b_human	F185A  [Orientation Restraint]	5ht1b_human	F185M  [Orientation Restraint]	gipr_rat	H170R
sctr_human	V144	sctr_human	I177	grm1_rat	S593
mc4r_human	Y268I	mc4r_human	C271	mshr_human	Y183
grm4_rat	A588	grm4_rat	A645	grm4_rat	N675
grm4_rat	G807	grm4_rat	I844	grm4_rat	I845
grm4_rat	L846	grm4_rat	K673	grm4_rat	K841
grm4_rat	M839	grm4_rat	F847	grm4_rat	P840
grm4_rat	T672	grm4_rat	T674	grm4_rat	T808
grm4_rat	Y843	grm4_rat	V589	grm4_rat	V842
mshr_mouse	D119N	mshr_mouse	M71K	c5ar_human	M120I  [Orientation Restraint]
c5ar_human	Y121F  [Orientation Restraint]	c5ar_human	I111T	c5ar_human	I124L  [Orientation Restraint]
c5ar_human	L112V	c5ar_human	I111M	c5ar_human	I124N  [Orientation Restraint]
c5ar_human	S114T	c5ar_human	A128T  [Orientation Restraint]	c5ar_human	L117Q  [Orientation Restraint]
c5ar_human	S114A	c5ar_human	Y121S  [Orientation Restraint]	c5ar_human	I124S  [Orientation Restraint]
c5ar_human	L125I  [Orientation Restraint]	c5ar_human	L115Q	c5ar_human	I204T  [Orientation Restraint]
c5ar_human	V208F  [Orientation Restraint]	c5ar_human	A203G	c5ar_human	I204M  [Orientation Restraint]
c5ar_human	F224S  [Orientation Restraint]	c5ar_human	T219S  [Orientation Restraint]	c5ar_human	L209V  [Orientation Restraint]

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Reference:

Jian Zhang and Yang Zhang, GPCRRD: G protein-coupled receptor spatial restraint database for 3-D structure modeling and function annotation, Bioinformatics, 26:3004-3005 (2010).