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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
lshr_rat P505-M586  [Contact Restraint] lshr_rat P505-K609  [Contact Restraint] lshr_rat N539-L612  [Contact Restraint]
lshr_rat M586-Y616  [Contact Restraint] hrh1_cavpo W161-F433  [Contact Restraint] hrh1_human S155-T194  [Contact Restraint]
mc4r_human E61-D90  [Contact Restraint] mc4r_human V50-I102  [Contact Restraint] mc4r_human I125-F184  [Contact Restraint]
mc4r_human D126-C196  [Contact Restraint] mtr1a_human P253-A279  [Contact Restraint] npy2r_human Q135-L227  [Contact Restraint]
ntr1_rat V67-M204  [Contact Restraint] ntr1_rat M204-V237  [Contact Restraint] ntr1_rat V237-Y324  [Contact Restraint]
ntr1_rat Y324-H348  [Contact Restraint] oprd_mouse W173-F218  [Contact Restraint] oprd_mouse F218-W274  [Contact Restraint]
oprd_mouse W274-Y308  [Contact Restraint] opsd_bovin G90-G121  [Contact Restraint] opsd_bovin D83-E122  [Contact Restraint]
opsd_bovin L131-A164  [Contact Restraint] opsd_bovin L79-W175  [Contact Restraint] opsd_bovin G121-V204  [Contact Restraint]
opsd_bovin E122-H211  [Contact Restraint] opsd_bovin A164-P215  [Contact Restraint] opsd_bovin C167-C222  [Contact Restraint]
opsd_bovin A117-M257  [Contact Restraint] opsd_bovin V204-F261  [Contact Restraint] opsd_bovin C222-C264  [Contact Restraint]
opsd_bovin A117-W265  [Contact Restraint] opsd_bovin W126-P267  [Contact Restraint] opsd_bovin P215-T289  [Contact Restraint]
opsd_bovin H211-A292  [Contact Restraint] opsd_bovin W265-A292  [Contact Restraint] opsd_mouse V87-E113  [Contact Restraint]
opsd_mouse E113-M257  [Contact Restraint] opsd_mouse M257-A292  [Contact Restraint] gnrhr_human N87-K121  [Contact Restraint]
gnrhr_human W280-F309  [Contact Restraint] gnrhr_mouse L58-L80  [Contact Restraint] gnrhr_rat N87-D318  [Contact Restraint]
gnrr2_claga D90-K124  [Contact Restraint] trfr_mouse N43-D71  [Contact Restraint] trfr_mouse Q105-F199  [Contact Restraint]
trfr_mouse Y200-W279  [Contact Restraint] trfr_mouse F199-Y282  [Contact Restraint] trfr_mouse R283-R306  [Contact Restraint]
trfr_mouse D71-N316  [Contact Restraint] trfr_rat Y93-F199  [Contact Restraint] 5ht2b_human D135-A187  [Contact Restraint]
5ht2b_human S222-W337  [Contact Restraint] 5ht4r_mouse D100-S197  [Contact Restraint] 5ht4r_mouse S197-W272  [Contact Restraint]
5ht4r_mouse W272-N308  [Contact Restraint] oxyr_human N57-D85  [Contact Restraint] oxyr_human Y209-F284  [Contact Restraint]
vg74_hhv8 D83-Y144  [Contact Restraint] vg74_hhv8 R208-R278  [Contact Restraint] vg74_hhv8 C39-C286  [Contact Restraint]
sctr_rat D196-R277  [Contact Restraint] sctr_rat R277-R299  [Contact Restraint] sctr_rat R299-E373  [Contact Restraint]
drd1_human D70-C106  [Contact Restraint] drd1_human C283-F319  [Contact Restraint] hrh2_canfa D186-D98  [Contact Restraint]
hrh2_canfa D98-T190  [Contact Restraint] opsd_bovin C264-C167  [Contact Restraint] opsd_bovin A292-E122  [Contact Restraint]
opsd_bovin H211-F293  [Contact Restraint] opsd_bovin A164-F261  [Contact Restraint] nk1r_rat L116-S290  [Contact Restraint]
nk1r_rat S290-V266  [Contact Restraint] nk1r_rat C80-F152  [Contact Restraint] gnrhr_mouse N87-D318  [Contact Restraint]
oprm_rat D114-D147  [Contact Restraint] oprm_rat D147-D114  [Contact Restraint] oprm_rat D147-H297  [Contact Restraint]
nk3r_rat V121-L81  [Contact Restraint] agtrb_rat S252-V108  [Contact Restraint] agtrb_rat V108-I258  [Contact Restraint]
agtrb_rat I258-L34  [Contact Restraint] agtrb_rat L34-L79  [Contact Restraint] agtrb_rat L79-K146  [Contact Restraint]
agtrb_rat K146-L202  [Contact Restraint] agtrb_rat L202-I241  [Contact Restraint] nk1r_rat I204-F264  [Contact Restraint]
nk3r_rat C244-I307  [Contact Restraint] ada2a_pig D79-Y426  [Contact Restraint] ada1a_rat M292-V185  [Contact Restraint]
ada1b_mesau F96-L182  [Contact Restraint] ada1b_mesau L182-S208  [Contact Restraint] ada1b_mesau S208-L314  [Contact Restraint]


Reference:

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