You can:
Name | Histamine H1 receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | HRH1 |
Synonym | H1R HH1R |
Disease | N/A for non-human GPCRs |
Length | 488 |
Amino acid sequence | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP |
UniProt | P31389 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3943 |
IUPHAR | N/A |
DrugBank | N/A |
Name | dimethylhistaprodifen |
---|---|
Molecular formula | C22H27N3 |
IUPAC name | 2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]-N,N-dimethylethanamine |
Molecular weight | 333.479 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | BDBM86170 PDSP2_001295 D0PB6B 2-[2-[3,3-di(phenyl)propyl]-3H-imidazol-4-yl]-N,N-dimethylethanamine N,N-Dimethyl-2-(3,3-diphenylpropyl)-1H-imidazole-4-(ethanamine) [ Show all ] |
Inchi Key | GNBOIGBQIBQOIA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24) |
PubChem CID | 10042467 |
ChEMBL | CHEMBL11553 |
IUPHAR | 1203 |
BindingDB | 86170 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Concentration | 30.0 uM | PMID10737740 | ChEMBL |
EC50 | 83.18 nM | PMID10737740 | ChEMBL |
EC50 | 120.23 nM | PMID10737740 | ChEMBL |
EC50 | 831.76 nM | PMID10737740 | ChEMBL |
Emax | 54.0 - | PMID10737740 | ChEMBL |
Emax | 85.0 - | PMID10737740 | ChEMBL |
Emax | 89.0 - | PMID10737740 | ChEMBL |
Kd | 0.776 nM | PMID10737740 | BindingDB |
Kd | 0.7762 nM | PMID10737740 | ChEMBL |
Kd | 1.38 nM | PMID10737740 | BindingDB,ChEMBL |
Kd | 2.51 nM | PMID10737740 | BindingDB |
Kd | 2.512 nM | PMID10737740 | ChEMBL |
Kd | 10.47 nM | PMID10737740 | BindingDB,ChEMBL |
Ki | 310.0 nM | PMID12626648 | BindingDB |
pKp | 6.4 - | PMID10737740 | ChEMBL |
Relative potency | 242.0 - | PMID10737740 | ChEMBL |
Relative potency | 265.0 - | PMID10737740 | ChEMBL |
Relative potency | 272.0 - | PMID10737740 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218