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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	METHDILAZINE
Molecular formula	C18H20N2S
IUPAC name	10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine
Molecular weight	296.432
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	GTPL7231 Methdilazinum NSC-244191 Product 5022 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)- BDBM81470 LS-979 Methodilazine NSC_14677 SR-01000944494-1 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine 1229-35-2 (hydrochloride) CAS_14677 Disyncram DTXSID6023282 Methdilazine [USAN:INN:BAN] NCI-C60720 Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)- Tacazyl 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine AC1L24C6 D04979 HTMIBDQKFHUPSX-UHFFFAOYSA-N Methdilazinum [INN-Latin] NSC169091 SCHEMBL121507 10H-Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]- C07175 DB00902 Metodilazina PDSP1_000149 Tacaryl 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine # 1982-37-2 CHEBI:6823 Disyncram (Salt/Mix) EINECS 217-841-6 Methdilazine [USP:INN:BAN] NCI60_001351 Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]- Tacryl 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine AC1Q7G4W D0LR0R L001130 Methilazine hydrochloride NSC244191 SR-01000944494 10-((1-methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine 10H-Phenothiazine, tannate (5:1) C18H20N2S Dilosyn (Salt/Mix) Methdilazine (INN) Metodilazina [INN-Spanish] PDSP2_000148 Tacaryl (TN) 10-[(1-Methyl-3-Pyrrolidinyl)methyl]phenothiazine CHEMBL1200959 Disyncran (Salt/Mix) [ Show all ]
Inchi Key	HTMIBDQKFHUPSX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
PubChem CID	14677
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81470
DrugBank	DB00902
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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