Home Research Services Publications People Teaching Job Opening Facilities News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind DockRMSD

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameHistamine H1 receptor
SpeciesHomo sapiens (Human)
GeneHRH1
SynonymHH1R
H1R
Hisr
H1 receptor
DiseaseVertigo's disease; Meniere's disease
Ocular allergy
Obesity
Nausea; Vomiting
Insomnia; Anxiety disorder
[ Show all ]
Length487
Amino acid sequenceMSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProtP35367
Protein Data Bank3rze
GPCR-HGmod modelP35367
3D structure modelThis structure is from PDB ID 3rze.
BioLiPBL0202178, BL0202179, BL0202180
Therapeutic Target DatabaseT77913
ChEMBLCHEMBL231
IUPHAR262
DrugBankBE0000442

Known ligands

You can:

Total entries: 2355
Page:  / 24 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5214612D structureCHEMBL3818128C19H23ClFN319.8482 / 1N/AN/A
7652D structureCHEMBL1090526C20H24FN3O341.435 / 02.7Yes
7852D structureCHEMBL60435C23H33N3O3399.5355 / 11.8Yes
10242D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
10472D structureCHEMBL270853C30H34N6OS526.7036 / 04.4No
5532552D structure7-Hydroxy RisperidoneC23H27FN4O3426.4927 / 11.7Yes
12562D structureCHEMBL256659C22H23F3N6O2S492.52111 / 03.9No
5479182D structureBilastineC28H37N3O3463.6225 / 12.3Yes
5214812D structureCHEMBL3806146C14H20N6272.3563 / 31.7Yes
5214842D structureCHEMBL3804837C14H20N6272.3563 / 31.7Yes
17882D structureciproxifanC16H18N2O2270.3323 / 12.5Yes
18402D structureCHEMBL272694C29H32N6OS512.6767 / 05.6No
19062D structureCHEMBL96732C20H23NO293.412 / 03.6Yes
19072D structureCHEMBL329566C20H23NO293.412 / 03.6Yes
19112D structureCHEMBL92667C20H23NO293.412 / 03.6Yes
19142D structureCHEMBL329268C20H23NO293.412 / 03.6Yes
19182D structureCHEMBL327651C20H23NO293.412 / 03.6Yes
19202D structureCHEMBL371352C20H23NO293.412 / 03.6Yes
22882D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
23332D structureCHEMBL249797C24H28N4O2S436.5746 / 23.9Yes
23982D structureCHEMBL1669412C19H21N3291.3983 / 02.1Yes
30212D structureUNII-10521U3EQAC23H31NO3S401.5654 / 04.2Yes
5215332D structureCHEMBL3818805C24H27ClN4O422.9572 / 24.8Yes
31452D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
32642D structureCHEMBL322194C39H48N4O6668.8358 / 05.4No
33262D structureCHEMBL3220637C11H18N6234.3073 / 30.8Yes
33442D structureUR-AK68C16H21N5O299.3783 / 32.1Yes
36972D structureCHEMBL3220892C17H23N5O313.4053 / 21.7Yes
5573902D structurePulicatins FC10H8N2O2S220.2464 / 21.5Yes
39182D structureCHEMBL2171022C25H28Cl2N2O5507.4086 / 12.7No
42932D structureCHEMBL398996C28H35N3O7S557.6628 / 1N/ANo
44702D structureUR-AK59C16H27N5O305.4263 / 33.1Yes
48902D structureCHEMBL270376C23H25F3N6OS2522.60911 / 04.9No
49542D structure5HT6-ligand-1C20H22BrN3O2S448.3794 / 03.6Yes
50552D structureBDBM50068818C32H39N5O6589.6938 / 22.9No
55772D structureCHEMBL330172C41H45N5O5687.8418 / 05.8No
56722D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
57512D structureAHOUBRCZNHFOSL-UHFFFAOYSA-NC19H20FNO3329.3715 / 13.5Yes
57542D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
58842D structureCHEMBL402422C22H26N6O2S438.558 / 03.4Yes
61912D structureCHEMBL1090186C21H27N3O2353.4665 / 02.5Yes
64582D structureCHEMBL1767144C22H23N3O3377.4445 / 10.6Yes
65072D structureCHEMBL180233C35H41F2N3O4605.7278 / 16.7No
4637172D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
5361282D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
72312D structureCHEMBL1258754C19H25N3O2327.4283 / 12.7Yes
72542D structureCHEMBL2208426C20H24Cl2N2O5S2507.4417 / 23.7No
74302D structureCHEMBL1210209C29H35FN4O3506.6227 / 24.9No
74692D structureN-Methyl-3,3-diphenylpropylamineC16H19N225.3351 / 13.6Yes
78892D structureCHEMBL158352C14H27N3237.3912 / 23.7Yes
80212D structureCHEMBL1258755C20H27N3O2341.4553 / 13.0Yes
82112D structureBW-723C86C16H18N2OS286.3933 / 23.0Yes
84692D structureCHEMBL1783963C20H22FN3323.4153 / 03.2Yes
85212D structureCHEMBL60143C31H41N3O5535.6856 / 14.4No
5216872D structureCHEMBL3754496C16H19FN2258.342 / 12.9Yes
86152D structureCHEMBL240567C28H33F2N3O5529.5858 / 1N/ANo
4420532D structureCHEMBL3357035C24H27ClN2O2410.9423 / 06.2No
88112D structureCHEMBL2207284C25H28Cl2N4O6S583.4818 / 42.2No
91612D structureCHEMBL2208420C21H22Cl2N2O2405.3194 / 05.5No
98532D structureAC-42C20H31NO301.4742 / 05.2No
5575682D structureCHEMBL397429C28H30N6OS498.6496 / 15.0Yes
101802D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
103812D structureCHEMBL96442C41H45N5O5687.8418 / 05.8No
105642D structureCHEMBL1277492C24H24ClNO4425.9095 / 12.1Yes
107442D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
112482D structureCHEMBL494982C17H21N3O283.3753 / 12.9Yes
115122D structureCHEMBL1257376C26H30FN3O2435.5434 / 04.5Yes
117392D structurepropranololC16H21NO2259.3493 / 23.0Yes
117912D structurecimetidineC10H16N6S252.344 / 30.4Yes
118022D structureCHEMBL2171045C24H26Cl2F3N3O4S580.4448 / 15.6No
120192D structureCHEMBL517244C35H44N2O508.753 / 07.8No
120392D structureCHEMBL3094114C21H25NO307.4372 / 04.5Yes
121332D structureCHEMBL2158791C28H36ClFN2O3503.0556 / 13.9No
5480262D structureCHEMBL3944629C20H26INO423.3382 / 0N/AN/A
133542D structureCHEMBL3220649C16H22N8S358.4686 / 42.2Yes
141772D structureCHEMBL2171021C25H30Cl2N2O4S525.4855 / 05.1No
146502D structureCHEMBL1945848C25H28N4O2416.5255 / 03.7Yes
5480492D structureCHEMBL3925977C31H40N4O3516.6867 / 12.9No
149792D structureCHEMBL158780C17H19N237.3461 / 13.4Yes
151432D structureCHEMBL66388C21H29N3323.4843 / 14.8Yes
152652D structureCHEMBL563451C22H28N4348.4943 / 04.4Yes
5219102D structureCHEMBL3819567C24H28N4OS420.5755 / 14.8Yes
154662D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
156892D structureCHEMBL3094128C27H35N3O4465.5946 / 14.0Yes
157792D structureCHEMBL603049C21H23FN2322.4272 / 04.3Yes
160772D structureCHEMBL1946122C22H25ClFNO2389.8954 / 14.8Yes
4422862D structureCHEMBL3321789C22H25ClFNO2389.8954 / 14.8Yes
5219322D structureAM-0902C17H15ClN6O2370.7976 / 02.3Yes
161172D structureCHEMBL1767165C40H52N4O3636.8816 / 07.6No
162842D structureCHEMBL64479C23H36N2O3388.5524 / 04.0Yes
164622D structureCHEMBL540982C19H20FNS313.4343 / 05.3No
166372D structureCHEMBL60559C24H31N3O3S441.596 / 12.5Yes
167232D structureCHEMBL1095819C20H22FN3323.4153 / 03.7Yes
167252D structureCHEMBL1087089C20H22FN3323.4153 / 03.7Yes
167802D structurePipamperoneC21H30FN3O2375.4885 / 12.0Yes
168762D structureGlemanserinC20H25NO295.4262 / 13.8Yes
5480812D structureCHEMBL3952251C20H23Cl2NO364.312 / 1N/AN/A
171442D structureCHEMBL2440659C15H11FN4O2S330.3377 / 12.4Yes
5219862D structureCHEMBL3775473C23H19FN2O4S2470.5337 / 14.2Yes
173862D structureCHEMBL21278C22H34N4O370.5415 / 13.8Yes

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218