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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | Ro 04-6790 |
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Molecular formula | C12H16N6O2S |
IUPAC name | 4-amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide |
Molecular weight | 308.36 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 4 |
XlogP | 1.7 |
Synonyms | Ro-04-6790 4-Amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide B7216 L000511 NCGC00015885-03 [ Show all ] |
Inchi Key | JELFWSXQTXRMAJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) |
PubChem CID | 5312145 |
ChEMBL | CHEMBL433461 |
IUPHAR | 274 |
BindingDB | 50090528 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 26.3 nM | PMID14584934 | BindingDB,ChEMBL |
Ki | 12.5893 - 50.1187 nM | PMID9730917, PMID9647481 | IUPHAR |
Ki | 44.7 nM | PMID15771424 | BindingDB,ChEMBL |
Ki | 47.0 nM | PMID19159187 | BindingDB,ChEMBL |
Ki | 50.0 nM | PMID15974573, PMID10937732 | BindingDB,ChEMBL |
Ki | 50.12 nM | PMID21190848, PMID15974573, PMID9925723 | ChEMBL |
Ki | 51.2861 nM | PMID14645659 | PDSP |
Ki | 51.29 nM | PMID14645659 | BindingDB |
Ki | 55.0 nM | PMID19433358, PMID12646038, PMID24850589, PMID18053713, PMID12825922 | BindingDB,ChEMBL |
Ki | 58.0 nM | Med Chem Res, (2005) 14:1:1 | ChEMBL |
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