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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesHomo sapiens (Human)
GeneHTR6
Synonym5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
5-HT-6
serotonin receptor 6
ST-B17
[ Show all ]
DiseaseSchizophrenia
Obesity
Neurological disease
Neurodegenerative disease
Emesis
[ Show all ]
Length440
Amino acid sequenceMVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProtP50406
Protein Data BankN/A
GPCR-HGmod modelP50406
3D structure modelThis predicted structure model is from GPCR-EXP P50406.
BioLiPN/A
Therapeutic Target DatabaseT16691
ChEMBLCHEMBL3371
IUPHAR11
DrugBankBE0000945

Known ligands

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Total entries: 4022
Page:  / 41 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4416682D structureCHEMBL3329446C20H28N2O312.4572 / 14.7Yes
4592342D structureCHEMBL3692880C18H17NO3S327.3984 / 12.9Yes
1272D structureCHEMBL1762574C18H21N5O2S371.4596 / 11.7Yes
2282D structureCHEMBL3664770C27H26N2O3S458.5764 / 14.3Yes
2952D structureCHEMBL1170086C21H17N5O2S2435.527 / 14.2Yes
4582D structureCHEMBL249034C17H19ClN4O2346.8155 / 23.9Yes
5292D structureAF-353C14H17IN4O2400.226 / 22.8Yes
5842D structuretolylpiperidine, 18nC22H23NO3S381.494 / 14.7Yes
6832D structureCHEMBL358948C19H15N3O2S2381.4685 / 13.2Yes
4592412D structureCHEMBL3692996C18H15Cl2NO4S412.2815 / 13.8Yes
9602D structureCHEMBL1917358C24H35N3O2S429.6235 / 04.9Yes
10072D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
14712D structure4365 CTC14H20N2O232.3272 / 12.7Yes
17342D structureCHEMBL1085836C32H33N3O4S555.6936 / 15.0No
21642D structureCHEMBL598444C23H24N4O2S420.5315 / 14.3Yes
21662D structureCHEMBL597009C23H24N4O2S420.5315 / 14.3Yes
21832D structureCHEMBL458002C29H28ClN5O2514.0265 / 24.3No
22202D structureSCHEMBL6925318C21H22N2O3S382.4784 / 12.8Yes
22702D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
22962D structureCHEMBL2165544C22H23F3N2O3S452.4927 / 04.9Yes
29202D structureCHEMBL368783C20H22N2O306.4092 / 14.1Yes
31552D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
5479292D structureCHEMBL3941102C28H31F3N4O2512.5778 / 13.9No
34012D structureCHEMBL1642882C18H19ClN4O2S390.8865 / 33.4Yes
35032D structureCHEMBL1173061C22H19N5O2S2449.5477 / 14.7Yes
36272D structureCHEMBL609994C20H22IN3O2S495.3794 / 24.1Yes
36282D structureBDBM50159192C20H22IN3O2S495.3794 / 24.1Yes
37302D structureCHEMBL606706C20H23N3O2S369.4834 / 23.4Yes
37312D structureCHEMBL606546C20H23N3O2S369.4834 / 23.4Yes
37322D structureBDBM50159207C20H23N3O2S369.4834 / 23.4Yes
38172D structureSCHEMBL6530223C21H23BrN2O3S463.394 / 04.5Yes
38322D structureNSC37904C12H13N3O2S263.3155 / 30.9Yes
40272D structureCHEMBL1642849C20H20N4O2S380.4665 / 33.4Yes
40932D structureCHEMBL1173578C21H16ClN5O2S2469.9627 / 04.6Yes
43072D structureButanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1)C18H22N2O5346.3836 / 4N/AN/A
44682D structureCHEMBL1080694C18H16ClFN2O2S378.8464 / 13.2Yes
45242D structureCHEMBL1086325C18H21NO3S331.434 / 12.7Yes
5479442D structureCHEMBL3883921C30H36N4O2S516.7045 / 05.4No
46112D structureCHEMBL2159474C16H17Cl3N2O3S2455.7936 / 15.0Yes
46602D structure120-78-5C14H8N2S4332.4726 / 05.6No
47652D structureCHEMBL3664787C24H25N3O2S419.5433 / 13.2Yes
5216022D structureCHEMBL3785626C14H21N5O2S323.4155 / 20.9Yes
4592632D structureCHEMBL3692841C17H15NO3S313.3714 / 12.6Yes
49532D structure5HT6-ligand-1C20H22BrN3O2S448.3794 / 03.6Yes
50962D structureCHEMBL94988C25H25ClN4O2S2513.0717 / 15.5No
52262D structureCID 44433197C18H20ClN5O2S2437.9617 / 12.7Yes
52532D structureSB-258719C18H30N2O2S338.514 / 03.5Yes
52942D structureSCHEMBL6924367C24H25N3O3S435.5424 / 22.7Yes
52992D structureCHEMBL2407545C20H19ClN4O3S430.9075 / 23.8Yes
54702D structureCHEMBL1642853C23H25ClN4O2S456.9895 / 4N/AN/A
56652D structureCHEMBL380777C18H19N3O3S357.4285 / 12.5Yes
56782D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
57802D structureCHEMBL568673C17H17Cl2N3O2S398.3024 / 03.3Yes
58462D structureCHEMBL246500C20H22N4O3S398.4817 / 11.9Yes
4636002D structureCHEMBL3696970C20H21NO5S387.456 / 22.3Yes
62172D structureCHEMBL2178747C22H29N3O3S415.5526 / 13.6Yes
62302D structureCHEMBL188182C16H16N2O2S300.3763 / 11.8Yes
62692D structureCHEMBL76237C19H22N2O3S358.4564 / 03.5Yes
63132D structureCHEMBL514383C20H22N4O2S2414.5427 / 12.9Yes
4419542D structureCHEMBL3409037C30H48N4O2496.744 / 04.9Yes
66872D structureCHEMBL574403C17H16ClN7O2S2449.9327 / 32.7Yes
68442D structureCHEMBL1080899C22H21N3O2S391.4894 / 03.2Yes
68472D structureCHEMBL1256255C39H48ClN5O5S3798.47311 / 38.8No
69272D structureCHEMBL75029C19H21ClN2O3S392.8984 / 04.1Yes
69442D structureCHEMBL1834347C16H21ClN4O2S368.884 / 12.7Yes
4637102D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
5361432D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
70442D structureSCHEMBL6925846C21H23N3O2S381.4944 / 21.7Yes
70582D structureCHEMBL180945C23H24N2O4392.4556 / 3N/AN/A
71372D structureCHEMBL1642428C22H26ClN3O2S431.9794 / 04.9Yes
71612D structureCHEMBL191972C15H15NO2S273.353 / 12.4Yes
71762D structureCHEMBL2159481C24H24F2N2O3S458.5247 / 14.6Yes
4592842D structureCHEMBL3693000C18H16ClNO3S361.844 / 13.6Yes
74132D structureCHEMBL518591C19H19ClN2O2S374.8833 / 04.2Yes
75422D structureCHEMBL1086079C18H21N3O2S343.4453 / 22.2Yes
76682D structureCHEMBL1642413C19H20FN3O2S373.4465 / 03.3Yes
78232D structureCHEMBL469668C20H29F3N2O2386.4597 / 13.9Yes
5479792D structureCHEMBL3983496C32H41N3O4531.6976 / 15.2No
5216692D structureCHEMBL3786432C17H24N4O3S364.4645 / 12.0Yes
80132D structureCHEMBL1668564C16H18N4O3S346.4056 / 12.1Yes
81492D structureCHEMBL237179C20H22ClN3O2S403.9254 / 03.5Yes
82022D structureBW-723C86C16H18N2OS286.3933 / 23.0Yes
83872D structureCHEMBL2159476C16H19ClN2O3S2386.9096 / 13.8Yes
84702D structureCHEMBL1783963C20H22FN3323.4153 / 03.2Yes
85382D structureCHEMBL1642423C19H19Br2N3O2S513.2484 / 04.5No
5216922D structureCHEMBL3754496C16H19FN2258.342 / 12.9Yes
86262D structureCHEMBL2165557C22H26N2O3S398.5214 / 04.4Yes
87072D structureCHEMBL1922625C15H17N5O2S331.3946 / 21.3Yes
88182D structureCHEMBL124382C19H20N2O292.3822 / 14.0Yes
88272D structureCHEMBL2159463C22H27FN2O3386.4675 / 13.9Yes
88952D structureCHEMBL1949969C23H27ClN4O2S459.0056 / 14.1Yes
89532D structure2-(Methylamino)diphenyl sulfoneC13H13NO2S247.3123 / 13.3Yes
92892D structureCHEMBL1949768C20H24ClNO4S409.9255 / 2N/AN/A
93492D structureCID 44433196C17H18ClN5O2S2423.9347 / 22.3Yes
93622D structureCHEMBL1642121C25H27N3O4S465.5687 / 03.3Yes
95442D structureGSK163090C25H29N5O415.5414 / 13.4Yes
96352D structureCHEMBL1081793C22H25FN2O3S416.5115 / 03.7Yes
99962D structuretolylpiperidine, 9gC18H22N2O282.3873 / 12.8Yes
100702D structureCHEMBL1642876C23H22N4O3S434.5145 / 33.1Yes
101232D structureCHEMBL3260801C19H19ClN2O2342.8233 / 13.5Yes

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