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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | Dimebolin |
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Molecular formula | C21H25N3 |
IUPAC name | 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole |
Molecular weight | 319.452 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 3.5 |
Synonyms | Latrepirdine (USAN/INN) NCGC00182554-04 ZINC8144259 12687-54-6 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole # [ Show all ] |
Inchi Key | JNODQFNWMXFMEV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3 |
PubChem CID | 197033 |
ChEMBL | CHEMBL589390 |
IUPHAR | N/A |
BindingDB | 50305261 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 890.0 nM | PMID19939513, PMID19443217 | BindingDB,ChEMBL |
IC50 | 1160.0 nM | PMID19945877 | BindingDB,ChEMBL |
Imax | 100.0 % | PMID19939513 | ChEMBL |
Ki | 26.0 nM | PMID24850589, PMID19939513 | BindingDB,ChEMBL |
Ki | 33.88 nM | PMID19945877 | ChEMBL |
Ki | 34.0 nM | PMID19939513 | BindingDB,ChEMBL |
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