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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL3219269
Molecular formulaC34H30F2N4O2
IUPAC nameN-[3-[1-[[2-fluoro-4-[1-(4-fluorophenyl)benzimidazole-2-carbonyl]phenyl]methyl]piperidin-4-yl]phenyl]acetamide
Molecular weight564.637
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.2
SynonymsN/A
Inchi KeyADPMYXOMYHHLJF-UHFFFAOYSA-N
Inchi IDInChI=1S/C34H30F2N4O2/c1-22(41)37-28-6-4-5-24(19-28)23-15-17-39(18-16-23)21-26-10-9-25(20-30(26)36)33(42)34-38-31-7-2-3-8-32(31)40(34)29-13-11-27(35)12-14-29/h2-14,19-20,23H,15-18,21H2,1H3,(H,37,41)
PubChem CID90666260
ChEMBLCHEMBL3219269
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5046.0 nMMedChemComm, (2011) 2:5:385ChEMBL
IC5080.0 nMMedChemComm, (2011) 2:5:385ChEMBL

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