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GPCR

NameProteinase-activated receptor 1
SpeciesHomo sapiens (Human)
GeneF2R
SynonymPAR-1
coagulation factor II (thrombin) receptor
Coagulation factor II receptor
PAR1
protease-activated receptor 1
[ Show all ]
DiseaseRestenosis
Acute coronary syndrome
Atherosclerosis
Cancer
Myocardial infarction
[ Show all ]
Length425
Amino acid sequenceMGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
UniProtP25116
Protein Data Bank3vw7
GPCR-HGmod modelP25116
3D structure modelThis structure is from PDB ID 3vw7.
BioLiPBL0217099
Therapeutic Target DatabaseT36483
ChEMBLCHEMBL3974
IUPHAR347
DrugBankBE0000928

Ligand

Name2-methyl-N-[2-methyl-3-(propionylamino)phenyl]benzamide
Molecular formulaC18H20N2O2
IUPAC name2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide
Molecular weight296.37
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP2.9
Synonyms1090450-34-2
2-methyl-N-(2-methyl-3-propanamidophenyl)benzamide
2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide
AKOS003571530
AN-329/43465271
[ Show all ]
Inchi KeyBQDYOVGQSJWZQQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H20N2O2/c1-4-17(21)19-15-10-7-11-16(13(15)3)20-18(22)14-9-6-5-8-12(14)2/h5-11H,4H2,1-3H3,(H,19,21)(H,20,22)
PubChem CID25642843
ChEMBLCHEMBL2047283
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition5.0 %PMID22408714ChEMBL

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