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Name | Histamine H1 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH1 |
Synonym | HH1R H1R Hisr H1 receptor |
Disease | Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder [ Show all ] |
Length | 487 |
Amino acid sequence | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS |
UniProt | P35367 |
Protein Data Bank | 3rze |
GPCR-HGmod model | P35367 |
3D structure model | This structure is from PDB ID 3rze. |
BioLiP | BL0202178, BL0202179, BL0202180 |
Therapeutic Target Database | T77913 |
ChEMBL | CHEMBL231 |
IUPHAR | 262 |
DrugBank | BE0000442 |
Name | CHEMBL320003 |
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Molecular formula | C35H38Cl2N4O5 |
IUPAC name | 1H-benzimidazol-2-yl-[1-[2-[3-(3,4-dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)pyrrolidin-3-yl]ethyl]piperidin-4-yl]methanone |
Molecular weight | 665.612 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 6.6 |
Synonyms | [3-{2-[4-(1H-Benzoimidazole-2-carbonyl)-piperidin-1-yl]-ethyl}-3-(3,4-dichloro-phenyl)-pyrrolidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone BDBM50290733 1-(3,4,5-Trimethoxy-benzoyl)-3-[2-[4-[1 H-benzoimidazole-2-carbonyl]-piperidin-1-yl]-ethyl]-3-(3,4-dichloro-phenyl)-pyrrolidine BSVGNAQMDXJFNE-UHFFFAOYSA-N SCHEMBL1387207 |
Inchi Key | BSVGNAQMDXJFNE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H38Cl2N4O5/c1-44-29-18-23(19-30(45-2)32(29)46-3)34(43)41-17-13-35(21-41,24-8-9-25(36)26(37)20-24)12-16-40-14-10-22(11-15-40)31(42)33-38-27-6-4-5-7-28(27)39-33/h4-9,18-20,22H,10-17,21H2,1-3H3,(H,38,39) |
PubChem CID | 15542679 |
ChEMBL | CHEMBL320003 |
IUPHAR | N/A |
BindingDB | 50290733 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 6.39 nM | Bioorg. Med. Chem. Lett., (1997) 7:22:2825 | ChEMBL |
IC50 | 6.4 nM | N/A | BindingDB |
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