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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | SMR000172981 |
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Molecular formula | C31H31FN4O4S |
IUPAC name | 4-amino-N-[2-(cyclopentylamino)-1-(4-methoxyphenyl)-2-oxoethyl]-N-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-thiazole-5-carboxamide |
Molecular weight | 574.671 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 6.2 |
Synonyms | 4-Amino-3-(4-methoxy-phenyl)-isothiazole-5-carboxylic acid [cyclopentylcarbamoyl-(4-methoxy-phenyl)-methyl]-(4-fluoro-phenyl)-amide MCULE-9218145043 AKOS000698026 Oprea1_358326 CHEMBL1459143 [ Show all ] |
Inchi Key | ADYMMHMVAVEKAG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C31H31FN4O4S/c1-39-24-15-7-19(8-16-24)27-26(33)29(41-35-27)31(38)36(23-13-11-21(32)12-14-23)28(20-9-17-25(40-2)18-10-20)30(37)34-22-5-3-4-6-22/h7-18,22,28H,3-6,33H2,1-2H3,(H,34,37) |
PubChem CID | 3192708 |
ChEMBL | CHEMBL1459143 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 2511.9 nM | PubChem BioAssay data set | ChEMBL |
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