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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesHomo sapiens (Human)
GeneGLP1R
SynonymGLP-1-R
GLP-1 receptor
glucagon-like peptide 1 receptor
GLP-1R
DiseaseNon-insulin dependent diabetes
Type 2 diabetes
Type 1/2 diabetes
Type 1 diabetes
Obesity
[ Show all ]
Length463
Amino acid sequenceMAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProtP43220
Protein Data Bank5vew, 5otv, 3c5t, 4zgm, 3iol, 5otu, 5vex, 5otw, 5otx, 3c59, 5nx2
GPCR-HGmod modelP43220
3D structure modelThis structure is from PDB ID 5vew.
BioLiPBL0418500,BL0418501, BL0418494,BL0418495, BL0380967, BL0143732, BL0143731, BL0379513,BL0379514, BL0418496,BL0418497, BL0143795, BL0143794, BL0378791,BL0378792, BL0167480, BL0167479, BL0324355,BL0324356, BL0418498,BL0418499, BL0324354, BL0380966
Therapeutic Target DatabaseT36075
ChEMBLCHEMBL1784
IUPHAR249
DrugBankBE0000857

Known ligands

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Total entries: 103726
Page:  / 1038 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
12D structureBAS 03421985C18H14N6O3362.3495 / 22.5Yes
22D structureSMR000154917C21H21FN4OS396.4845 / 13.9Yes
52D structureMLS003120225C20H16ClN3O2365.8174 / 13.2Yes
92D structureCHEMBL1354533C22H26N2O3S398.5214 / 13.9Yes
132D structureMLS001098390C22H27BrN4O4491.3865 / 24.3Yes
202D structureSMR000082495C23H24N4O3404.474 / 11.9Yes
222D structureCHEMBL1734241C18H19F3N4O4S2476.48910 / 22.1Yes
242D structureAC1NKC6OC24H34N2O4414.5465 / 23.7Yes
282D structureAC1P9W8YC22H25ClN2O3400.9034 / 04.3Yes
402D structureMLS003124119C23H19N3O3385.4234 / 13.9Yes
442D structureUPCMLD04ASTW002121C26H32N2O3420.5533 / 24.6Yes
522D structureSMR000115985C21H18N4O3S406.465 / 13.8Yes
552D structure3-(4-bromophenyl)-1-(cyclopropylcarbonyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-olC14H12BrF3N2O2377.1616 / 13.3Yes
582D structureSMR000006315C18H20ClNO4S381.8715 / 12.8Yes
612D structure5-{[3-(dimethylamino)propyl]amino}-2-phenyl-1,3-oxazole-4-carbonitrileC15H18N4O270.3365 / 13.3Yes
652D structureSMR001217115C28H28F4N2O7580.53312 / 1N/ANo
662D structureMLS000094053C16H16FN5O2S361.3958 / 03.5Yes
1002D structure2-(4-chlorophenyl)-N'-(3-pyridinylmethylene)-4-quinolinecarbohydrazideC22H15ClN4O386.8394 / 14.3Yes
1052D structureSMR000038563C25H31N7O3477.5696 / 12.4Yes
1072D structureMLS001361981C28H30F4N2O6566.5511 / 2N/ANo
1132D structure5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidineC20H21N5O4395.4198 / 13.2Yes
1202D structureSMR000016661C18H15N3O2305.3373 / 12.7Yes
1372D structureN-Allyl-2-(4-benzhydryl-piperazin-1-yl)-acetamideC24H29N3O5439.5127 / 3N/AN/A
1452D structureMLS000829697C30H29N3O8559.57510 / 02.8No
1462D structureMLS000735125C23H32FN3O2401.5265 / 03.9Yes
1542D structureIFLab1_004408C19H23NO2S329.4583 / 13.4Yes
1552D structureMLS000527948C16H19N3OS301.4084 / 13.1Yes
1582D structureMLS001235152C20H20FN3O4385.3955 / 21.9Yes
1622D structureMLS003178907C29H31ClN2O5S555.0866 / 03.9No
1632D structureCHEMBL1396550C24H28N2OS392.5613 / 15.8No
1662D structureMLS000103088C17H20N2OS300.423 / 13.2Yes
1792D structureAC1LRY9SC19H19N9O389.4237 / 13.2Yes
1802D structureMLS001072616C24H25N3O3403.4824 / 14.1Yes
1842D structureAC1MOBESC25H24N2O6S480.5357 / 12.9Yes
1892D structure2-(2-nitrophenoxy)-N-propylacetamideC11H14N2O4238.2434 / 11.6Yes
1912D structureN-(4-bromo-2,6-dimethylphenyl)-2-nitrobenzamideC15H13BrN2O3349.1843 / 13.2Yes
1922D structure2-phenyl-N-(2-phenylethyl)butanamideC18H21NO267.3721 / 14.0Yes
1932D structureN-{2-[(4-chlorophenyl)sulfanyl]ethyl}-N~2~-(2,3-dimethylphenyl)-N~2~-(methylsulfonyl)glycinamideC19H23ClN2O3S2426.9745 / 14.0Yes
1952D structureMLS000684722C15H14N2O2S286.3495 / 14.2Yes
1992D structure3-[Azepan-1-yl-(1-tert-butyl-1H-tetrazol-5-yl)-methyl]-benzonitrileC19H26N6338.4595 / 02.9Yes
2042D structureMLS000733515C21H21F2N3O3401.4147 / 03.2Yes
2052D structureMLS000684946C23H31ClN4O3S2511.0967 / 1N/ANo
2102D structureMLS000392662C10H14ClN3S2275.8133 / 23.6Yes
2172D structureMLS000569662C18H20N4O3S372.4436 / 13.2Yes
2202D structure2,6-dimethyl-4-[2-(phenylsulfonyl)acetyl]phenyl N,N-dimethylcarbamateC19H21NO5S375.4395 / 03.1Yes
2222D structureMLS002639376C10H6ClNOS2255.7343 / 13.4Yes
5573122D structureAC1NWZI7C17H8F4N2OS364.3188 / 14.6Yes
5573142D structureMLS000849868C15H17N3OS287.3813 / 32.5Yes
5573152D structureMLS003115380C15H17N3OS287.3813 / 32.5Yes
2322D structureAC1NNPKRC18H20FNO4S365.4195 / 12.7Yes
2472D structureMLS001362111C28H37F3N2O6S586.66711 / 1N/ANo
2482D structureAC1NUSAFC18H18BrN3O3S436.3245 / 23.1Yes
2522D structureMLS000912240C19H14ClN3O3367.7894 / 23.7Yes
2532D structure4-ethyl-N-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideC14H18F3N3S317.3745 / 12.8Yes
2542D structureCHEMBL1320515C18H17ClN2O2S360.8563 / 12.9Yes
2552D structureBAS 01923086C20H23FN2O3S390.4735 / 13.1Yes
2562D structureSMR000243071C24H25N3O5S467.547 / 23.6Yes
2572D structureMLS001074397C28H29BrN4O4565.4686 / 25.1No
2632D structureMLS000882561C23H22O4362.4254 / 14.4Yes
2642D structureMLS003106901C12H15NO4237.2554 / 11.9Yes
2682D structureBAS 09528871C15H12Cl2N2O2S355.2334 / 13.6Yes
2812D structure3-(4-chlorophenyl)-5-(1,1,2,2-tetrafluoroethyl)-1H-pyrazoleC11H7ClF4N2278.6355 / 13.8Yes
2832D structureMLS000734874C23H31N3O3397.5194 / 03.4Yes
2842D structure1-(4-ethoxyphenyl)-2-[3-(1H-pyrazol-1-yl)propyl]-2,3,4,9-tetrahydro-1H-beta-carbolineC25H28N4O400.5263 / 14.3Yes
2852D structureAC1LE41XC18H18FN3OS343.424 / 13.3Yes
2862D structureSMR000131481C21H25N3O2351.453 / 12.1Yes
2962D structureSMR000091688C14H14FN3O2275.2836 / 13.2Yes
3062D structureMLS002157455C23H29N5O2S2471.6388 / 03.8Yes
3072D structure5-amino-3-(3-aminopropyl)-1H-pyrazole-4-carbonitrileC7H11N5165.24 / 3-0.1Yes
3092D structure1-(4-chlorophenyl)-3-(2-hydroxy-5-methylphenyl)propane-1,3-dioneC16H13ClO3288.7273 / 14.3Yes
3102D structureAC1NT5A7C17H17NO3283.3274 / 13.5Yes
3112D structureMLS002768222C19H23Br2NO3S505.2654 / 05.6No
3132D structureSMR000065140C20H19N3O5S413.4488 / 13.2Yes
3142D structureCHEMBL1559360C18H16FNO5S2409.4467 / 03.6Yes
3152D structureSMR000155256C19H17ClN4O2S400.8817 / 26.6No
3172D structureCHEMBL179161C17H14N2O3S3390.496 / 23.1Yes
3282D structureN-[2-(benzyloxy)-5-bromobenzyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-amineC19H22BrN5OS448.3836 / 14.0Yes
3292D structureMLS000757188C19H25NO2299.4142 / 16.1No
3302D structureAC1LLI6BC21H26BrNO2404.3483 / 05.1No
3342D structureMLS000336683C21H20N4O3S408.4767 / 23.6Yes
3392D structure5-chloro-2-(ethylsulfonyl)-N-(4-methoxybenzyl)pyrimidine-4-carboxamideC15H16ClN3O4S369.826 / 11.8Yes
3452D structure5-Nitro-2-p-tolyl-1H-benzoimidazoleC14H11N3O2253.2613 / 13.8Yes
3462D structure2-(4-fluorobenzyl)-6-(4-methylstyryl)-3(2H)-pyridazinoneC20H17FN2O320.3673 / 03.8Yes
3502D structure2-{1-[(4-methoxyphenyl)carbamothioyl]-3-oxopiperazin-2-yl}-N-(4-methylphenyl)acetamideC21H24N4O3S412.5084 / 32.0Yes
3522D structureCHEMBL1435065C20H19NO5S2417.4947 / 14.3Yes
3622D structureAC1OJ1IVC19H23N5321.4285 / 24.4Yes
3672D structureSMR000005572C21H23N3O4S413.4926 / 12.8Yes
3722D structureAC1O08MQC20H19ClN4350.853 / 15.5No
3732D structureF1243-0137C17H20ClNO3321.8014 / 12.8Yes
3812D structureMLS000526436C18H31N3S321.5272 / 23.7Yes
3872D structureAC1MR1M1C25H24FN5O2445.4985 / 22.7Yes
3912D structureChemDiv3_010013C18H20N2O4S360.4285 / 12.2Yes
3952D structureMLS001100937C24H25FN2O2392.4743 / 13.6Yes
3992D structureCHEMBL1417984C21H27N3O3S401.5255 / 13.1Yes
4002D structureMLS000882705C23H19N3O2369.4244 / 04.3Yes
4012D structureMLS002402777C18H14N2O274.3231 / 13.5Yes
4072D structurediazepamC16H13ClN2O284.7432 / 03.0Yes
4102D structureethyl 4-(7-{[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-1-carboxylateC29H36N4O4504.6315 / 03.6No
4162D structureDibromosalicilC14H8Br2O4400.0224 / 24.7Yes
4172D structure3-amino-N-(3-bromo-4-methoxyphenyl)-4-chlorobenzene-1-sulfonamideC13H12BrClN2O3S391.6645 / 23.1Yes

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