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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | quetiapine |
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Molecular formula | C21H25N3O2S |
IUPAC name | 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol |
Molecular weight | 383.51 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | AS-35258 URKOMYMAXPYINW-UHFFFAOYSA- C07397 CS-1171 DSSTox_GSID_23546 [ Show all ] |
Inchi Key | URKOMYMAXPYINW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 |
PubChem CID | 5002 |
ChEMBL | CHEMBL716 |
IUPHAR | 50 |
BindingDB | 50095890 |
DrugBank | DB01224 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Ki | <1000.0 nM | MedChemComm, (2012) 3:5:580 | ChEMBL |
Ki | 33.0 nM | PMID8522988, PMID9430133 | PDSP,BindingDB |
Ki | 1400.0 nM | PMID18595716 | PDSP,BindingDB,ChEMBL |
Ki | 1864.0 nM | PMID18059438 | PDSP |
Ki | 1865.0 nM | PMID12629531 | PDSP,BindingDB |
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