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Name | Histamine H1 receptor |
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Species | Cavia porcellus (Guinea pig) |
Gene | HRH1 |
Synonym | H1R HH1R |
Disease | N/A for non-human GPCRs |
Length | 488 |
Amino acid sequence | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP |
UniProt | P31389 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3943 |
IUPHAR | N/A |
DrugBank | N/A |
Name | (R)-alpha-Methylhistamine |
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Molecular formula | C6H11N3 |
IUPAC name | (2R)-1-(1H-imidazol-5-yl)propan-2-amine |
Molecular weight | 125.175 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | -0.3 |
Synonyms | LS-177199 PDSP1_000542 r-alpha-methylhistamine [3H]-R-alpha-Methylhistamine (R)-2-(3H-Imidazol-4-yl)-1-methyl-ethylamine [ Show all ] |
Inchi Key | XNQIOISZPFVUFG-RXMQYKEDSA-N |
Inchi ID | InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1 |
PubChem CID | 156615 |
ChEMBL | CHEMBL268229 |
IUPHAR | 1236, 1237 |
BindingDB | 50215536, 22904 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 0.49 - | PMID1967317 | ChEMBL |
ED50 | 1.7 mg.kg-1 | PMID9871662 | ChEMBL |
Ki | <10000.0 nM | PMID7752184, PMID9871662 | BindingDB,ChEMBL |
Ki | 0.5 nM | PMID1321744 | BindingDB |
pD2 | 5.4 - | PMID7752184, PMID9871662 | ChEMBL |
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