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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	148672-13-3
Molecular formula	C29H31N5O3
IUPAC name	N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide
Molecular weight	497.599
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.9
Synonyms	NCGC00025178-02 UNII-2LLH6CEB40 01,1'-Biphenyl-4-carboxamide, N-04-methoxy-3-((4-methyl-1-piperazinyl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)- AJ-23652 CCG-204874 EX-A1904 GTPL14 N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride RT-022632 2'-Methyl-4'-(5-methyl-(1,2,4)-oxadiazol-3-yl)biphenyl-4-carboxylic acid (4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)amide AX8233421 CHEMBL15928 GR 127935 HCl Lopac-G-5793 N-[4-Methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4' -(5-methyl -1,2,4-oxadiazol-3-yl) [1,1'-biphenyl]-4-carboxamide NCGC00015476-02 NCGC00015476-05 ST24048407 (1,1'-Biphenyl)-4-carboxamide, N-(4-methoxy-3-(4-methyl-1-piperazinyl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)- AC-27423 BRD-K11911061-003-02-8 D06DZI GR-127935 MLS002153332 N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide PDSP1_000436 YDBCEBYHYKAFRX-UHFFFAOYSA-N AKOS016004225 CHEBI:64114 FT-0730872 KB-258223 N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide N-[4-methoxy-3-(4-methylpiperazino)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride NCGC00015476-03 SCHEMBL7795263 2LLH6CEB40 BCP08033 cid_11497466 GR 127935 hydrochloride hydrate Lopac0_000790 N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride NCGC00025178-01 Tocris-1477 AC1L32QI C29H31N5O3 DTXSID90164044 GR127935 MolPort-003-941-511 N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide PDSP2_000434 ZINC598509 ANW-62582 GR 127935 L000275 N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide NCGC00015476-01 NCGC00015476-04 SMR001230745 BDBM79215 CTK8B9473 GR-127,935 LS-44235 N-[4-METHOXY-3-(4-METHYLPIPERAZIN-1-YL)-PHENYL]-4-[2-METHYL-4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)PHENYL]BENZAMIDE [ Show all ]
Inchi Key	YDBCEBYHYKAFRX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)
PubChem CID	107780
ChEMBL	CHEMBL15928
IUPHAR	14
BindingDB	79215
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IA	0.86 -	PMID15887956	ChEMBL
IC50	52.0 nM	PMID10669578	BindingDB,ChEMBL
Intrinsic activity	0.8 -	PMID17629698	ChEMBL
Ki	0.12 nM	PMID8788495	PDSP,BindingDB
Ki	0.1259 nM	PMID8057272	ChEMBL
Ki	0.7 nM	, PMID16143528	BindingDB
Ki	0.7 nM	PMID16143528, Bioorg. Med. Chem. Lett., (1997) 7:24:3183	ChEMBL
Ki	0.74 nM	PMID9397179	PDSP
Ki	0.794328 - 2.51189 nM	PMID9397179, PMID9303567, PMID9776361, PMID8957260, PMID9548813	IUPHAR
Ki	1.25 nM	PMID9303567	PDSP,BindingDB
Ki	1.259 nM	PMID8057272	ChEMBL
Ki	2.1 nM	PMID9303569	PDSP,BindingDB
Ki	2.51 nM	PMID9776361, PMID9548813, PMID9303567	PDSP,BindingDB
Ki	2.51189 - 5.01187 nM	PMID8967979	IUPHAR
Ki	2.512 nM	PMID9548813	ChEMBL
Ki	12.0 nM	PMID16143528	BindingDB
Ki	12.3 nM	PMID16143528	PDSP,ChEMBL

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