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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL3805176
Molecular formula	C22H25NO5S
IUPAC name	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(E)-4-phenoxybut-1-enyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid
Molecular weight	415.504
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.6
Synonyms	BDBM50169548 SCHEMBL20183230
Inchi Key	GJEDKMXFVUIJBT-QEJOXDNVSA-N
Inchi ID	InChI=1S/C22H25NO5S/c24-18-12-20-16(9-10-19(28-20)21-23-17(13-29-21)22(25)26)15(18)8-4-5-11-27-14-6-2-1-3-7-14/h1-4,6-8,13,15-16,18-20,24H,5,9-12H2,(H,25,26)/b8-4+/t15-,16-,18-,19-,20+/m1/s1
PubChem CID	127052614
ChEMBL	CHEMBL3805176
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID26985320	ChEMBL
EC50	3.9 nM	PMID26985320	ChEMBL
Emax	38.0 %	PMID26985320	ChEMBL
Emax	98.0 %	PMID26985320	ChEMBL

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