You can:
Name | Muscarinic acetylcholine receptor M4 |
---|---|
Species | Homo sapiens (Human) |
Gene | CHRM4 |
Synonym | HM3 M4 receptor cholinergic receptor Chrm-4 cholinergic receptor, muscarinic 4 |
Disease | Produce mydriasis and cycloplegia for diagnostic purposes Hypertension Irritable bowel syndrome Moderate and severe psychomotor agitation Mydriasis diagnosis [ Show all ] |
Length | 479 |
Amino acid sequence | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR |
UniProt | P08173 |
Protein Data Bank | 5dsg |
GPCR-HGmod model | P08173 |
3D structure model | This structure is from PDB ID 5dsg. |
BioLiP | BL0339919,BL0339921, BL0339920 |
Therapeutic Target Database | T20709, T50918 |
ChEMBL | CHEMBL1821 |
IUPHAR | 16 |
DrugBank | BE0000405 |
Name | 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine |
---|---|
Molecular formula | C15H17N3 |
IUPAC name | 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine |
Molecular weight | 239.322 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | BDBM50342538 PHA-670080 CZWQBSKNHUVZLI-UHFFFAOYSA-N PNU-57378E PF-3246799 [ Show all ] |
Inchi Key | CZWQBSKNHUVZLI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H17N3/c1-2-4-12(5-3-1)10-15-17-11-13-6-8-16-9-7-14(13)18-15/h1-5,11,16H,6-10H2 |
PubChem CID | 25070582 |
ChEMBL | CHEMBL1770373 |
IUPHAR | N/A |
BindingDB | 50342538 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 300.0 nM | PMID21195614 | BindingDB,ChEMBL |
IC50 | 6800.0 nM | PMID21195614 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218