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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	20-Hydroxy-leukotriene B4
Molecular formula	C20H32O5
IUPAC name	(5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.5
Synonyms	(5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid 5,12,20-THETE AKOS027378121 LMFA03020018 w-Hydroxy-LTB4 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate 20-OH-5S,12S-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid C04853 NCGC00161274-01 [S-[R,S-(E,Z,E,Z)]]-5,12,20-trihydroxy-6,8,10,14-Eicosatetraenoic acid (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoate 20-hydroxy Leukotriene B4 20-OH-LTB4 D0I4FF SR-01000946893 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate 20-hydroxy-LTB4 5,12,20-Trihete BDBM85696 LTB4-20-hydroxy ZINC4629872 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoic acid 20-OH-5S,12S-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid 6,8,10,14-Eicosatetraenoic acid, 5,12,20-trihydroxy-, (5S,6Z,8E,10E,12R,14Z)- CHEBI:15646 omega-Hydroxy-LTB4 (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid 20-hydroxy LTB4 AC1NQXIZ GTPL3399 SR-01000946893-1 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoic acid 20-hydroxyleukotriene B4 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoate BML1-E05 LTB4_20-Hydroxy [S-[R,S-(E,Z,E,Z)]]-5,12,20-trihydroxy-6,8,10,14-Eicosatetraenoate 1075AH 20-OH-Leukotriene B4 79516-82-8 CHEMBL1593789 SCHEMBL142275 [ Show all ]
Inchi Key	PTJFJXLGRSTECQ-PSPARDEHSA-N
Inchi ID	InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1
PubChem CID	5280745
ChEMBL	N/A
IUPHAR	3399
BindingDB	85696
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.54 nM	PMID11006272	BindingDB
Ki	7.6 nM	PMID9177352	IUPHAR

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