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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | MLS000331008 |
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Molecular formula | C19H17F3N4O4 |
IUPAC name | 2-[3-hydroxy-4-[4-(4-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazol-3-yl]phenoxy]acetohydrazide |
Molecular weight | 422.364 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 4 |
XlogP | 2.6 |
Synonyms | 2-{3-hydroxy-4-[4-(4-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazol-3-yl]phenoxy}acetohydrazide MolPort-001-733-788 2-[(4E)-4-[4-(4-methoxyphenyl)-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-3-oxidanylidene-cyclohexa-1,5-dien-1-yl]oxyethanehydrazide 879464-60-5 F3385-1487 [ Show all ] |
Inchi Key | BNUDLNJGHPVWMB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H17F3N4O4/c1-29-11-4-2-10(3-5-11)16-17(25-26-18(16)19(20,21)22)13-7-6-12(8-14(13)27)30-9-15(28)24-23/h2-8,27H,9,23H2,1H3,(H,24,28)(H,25,26) |
PubChem CID | 2014540 |
ChEMBL | CHEMBL1526545 |
IUPHAR | N/A |
BindingDB | 61504 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 17782.8 nM | PubChem BioAssay data set | ChEMBL |
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