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Name | Melanin-concentrating hormone receptor 1 |
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Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL377874 |
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Molecular formula | C35H32Cl2N4 |
IUPAC name | 3-[4-[1-(1-benzylpiperidin-4-yl)-3-(4,6-dichloro-1H-benzimidazol-2-yl)propyl]phenyl]benzonitrile |
Molecular weight | 579.569 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 8.8 |
Synonyms | 4''-[1-(1-benzyl-piperidin-4-yl)-3-(4,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile BDBM50186800 SCHEMBL12561197 4''-[1-(1-benzyl-piperidin-4-yl)-3-(5,7-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile |
Inchi Key | GAWJZFWFWAJWRF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H32Cl2N4/c36-30-20-32(37)35-33(21-30)39-34(40-35)14-13-31(28-15-17-41(18-16-28)23-24-5-2-1-3-6-24)27-11-9-26(10-12-27)29-8-4-7-25(19-29)22-38/h1-12,19-21,28,31H,13-18,23H2,(H,39,40) |
PubChem CID | 11433168 |
ChEMBL | CHEMBL377874 |
IUPHAR | N/A |
BindingDB | 50186800 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 26.0 nM | PMID16690312 | BindingDB,ChEMBL |
Ki | 53.0 nM | PMID16690312 | BindingDB,ChEMBL |
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