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GPCR

NameThyrotropin receptor
SpeciesHomo sapiens (Human)
GeneTSHR
SynonymThyroid-stimulating hormone receptor
TSH receptor
Thyrotropin Receptor
TSH-R
LGR3
DiseaseDiagnostic test to differentiate primary and secondary hypothyroidism
Thyroid cancer
Thyroid cancer diagnosis
Length764
Amino acid sequenceMRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
UniProtP16473
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT60606
ChEMBLCHEMBL1963
IUPHAR255
DrugBankN/A

Known ligands

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Total entries: 16717
Page:  / 168 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
212D structureSMR000082495C23H24N4O3404.474 / 11.9Yes
432D structureUPCMLD04ASTW002110C26H32N2O3420.5533 / 24.6Yes
592D structureSMR000006315C18H20ClNO4S381.8715 / 12.8Yes
672D structureMLS000094053C16H16FN5O2S361.3958 / 03.5Yes
1092D structureN-(1,3-benzodioxol-5-ylmethyl)-3-(2,5,7-trimethyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)propanamideC19H21N5O3367.4096 / 12.1Yes
1612D structureuwisc-betapep-72C40H71N7O9794.04811 / 9-2.2No
1782D structureSR-01000838868C14H27NO6305.3717 / 4N/AN/A
1822D structureMLS000027156C23H30N6390.5355 / 03.7Yes
2032D structureMLS000115918C14H13N3O2S2319.3976 / 02.9Yes
2822D structureNCGC00012273C20H24N6O364.4536 / 01.6Yes
3542D structureSMR000028904C21H22N6O3406.4468 / 12.7Yes
3982D structure6-IodonordihydrocapsaicinC17H26INO3419.3033 / 24.8Yes
4232D structureSMR000072988C17H15ClN2O4346.7675 / 13.8Yes
4252D structureMLS000065772C13H15N3OS3325.4636 / 14.0Yes
4932D structureMLS001095734C20H20N2O4S384.456 / 13.4Yes
5002D structureSMR000012485C20H22F3N5O2S453.4849 / 13.3Yes
5282D structureDIETHYL ETHYLPHOSPHONATEC6H15O3P166.1573 / 00.6Yes
5362D structureAC1LJP8IC18H18ClFN2O2348.8024 / 03.7Yes
5482D structureSMR000024980C15H10F7NO353.248 / 04.2Yes
5702D structureMLS000113955C11H8BrNO4S330.1525 / 13.6Yes
5992D structureSMR000047551C17H11ClN4O2S370.8116 / 03.8Yes
6032D structureSMR000004969C26H29ClN6O3509.0077 / 1N/ANo
6042D structureMLS000087136C23H21ClN4O4452.8956 / 14.4Yes
6202D structureMLS000112244C15H13N3O2S299.3486 / 13.0Yes
6572D structureSMR000032427C17H19N3O3313.3574 / 00.5Yes
7122D structureSMR000000828C26H22N2O6S490.537 / 23.8Yes
7412D structureN-[2-(4-benzylpiperazin-1-yl)ethyl]-2-(6-oxo-3-phenylpyridazin-1(6H)-yl)acetamideC25H29N5O2431.545 / 12.1Yes
7842D structure3-hydroxy-5-(3,4,5-trimethoxyphenyl)cyclohex-2-en-1-oneC15H18O5278.3045 / 11.6Yes
8742D structure{[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetonitrileC17H13N3O2S323.375 / 03.1Yes
8812D structureMLS000068755C22H18ClN5O403.874 / 14.7Yes
9312D structureAC1MDXZYC17H16F2O4322.3086 / 03.5Yes
9442D structuremethyl 2-amino-4-(3,4-dichlorophenyl)-6,7-dimethyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylateC18H16Cl2N2O4395.2365 / 13.3Yes
9502D structureSMR000109040C15H13NO4S2335.3927 / 03.8Yes
9542D structureSMR000059935C13H14F3NO4305.2537 / 21.8Yes
9552D structureAC1LFMYVC17H25BrN2337.3052 / 03.9Yes
9572D structureSMR000062656C19H25N3O2S359.4884 / 13.2Yes
9582D structureNCGC00090226-01C27H40N6O2480.6577 / 03.9Yes
9692D structureUPCMLD02ASTW001224C34H36FN3O4569.6775 / 04.8No
10012D structureSMR000048110C20H22ClN3O2371.8654 / 12.7Yes
10522D structureNCGC00012487C16H15N3O265.3164 / 13.5Yes
10692D structureSMR000092165C20H22N4O334.4234 / 14.3Yes
10732D structureSMR000030768C22H24FN3O2S413.5116 / 13.4Yes
10892D structureBAS 09530603C21H23F2N5O399.4466 / 02.6Yes
11022D structure5-(2-Morpholin-4-yl-ethylamino)-2-phenoxymethyl-oxazole-4-carbonitrileC17H20N4O3328.3727 / 12.4Yes
11132D structureMLS000054921C14H15NO3245.2783 / 01.3Yes
11192D structureAC1LORZKC17H19FN2OS318.414 / 03.9Yes
11372D structure4,6-dimethyl-2-({2-[(4-methylphenyl)sulfonyl]ethyl}sulfanyl)nicotinonitrileC17H18N2O2S2346.4635 / 03.5Yes
11592D structureAC1LCTPQC20H24N6348.4545 / 03.8Yes
12332D structureSMR000068198C22H19N3O3373.4124 / 13.1Yes
12432D structureSMR000082223C20H28N2O4S392.5146 / 13.0Yes
12722D structureASN 07460871C18H24N2O4S364.465 / 13.1Yes
13032D structureMLS000109191C21H15N5O2S401.4446 / 03.4Yes
13242D structureSMR000095165C21H22ClN3O3399.8755 / 04.6Yes
13552D structureSMR000030857C17H23N3O4S365.4485 / 20.9Yes
13932D structureMLS000057790C18H13N3O3319.326 / 13.7Yes
14422D structureMLS000573697C17H21Cl3N4OS2467.8524 / 35.6No
15052D structureN-cyclopentyl-5-[1-[2-(3,5-dimethylpiperidin-1-yl)-2-oxoethyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]pentanamideC27H38N4O4482.6254 / 13.3Yes
15452D structureUPCMLD04ADMT001034C31H36N2O4500.6394 / 35.2No
15542D structurehexachloropheneC13H6Cl6O2406.8892 / 27.5No
15862D structureMLS001099132C24H21N5O3S2491.5849 / 03.9Yes
15882D structureMLS000080402C21H22N2O5382.4166 / 22.0Yes
16012D structureCHEMBL565654C20H17N3OS347.4365 / 14.7Yes
16102D structureAC1LDFVBC13H7Cl2N3O3324.1175 / 03.6Yes
16142D structureSMR000044012C23H31N5O2409.5347 / 03.7Yes
16182D structureMLS000037786C19H14N2O3S350.3926 / 03.7Yes
16222D structureSMR000062829C19H17NO4323.3485 / 04.0Yes
16262D structureSMR000078129C15H15F3N2O2S344.3528 / 03.2Yes
16462D structureSMR000044353C20H24N6OS396.5138 / 12.6Yes
16522D structureNSC-309874C26H23ClN2OS446.9933 / 16.6No
16992D structureCoumarin-3-carboxylic acidC10H6O4190.1544 / 12.2Yes
17242D structureSMR000047763C22H16ClN5O2S449.9136 / 15.2No
17782D structureSMR000005020C25H28N6O3460.5388 / 03.4Yes
18032D structure3,4-dichloro-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)benzamideC18H13Cl2NO3362.2063 / 14.4Yes
18182D structureSMR000033485C23H28ClN5O4473.9586 / 31.7Yes
18492D structureUPCMLD04BGHW001051C19H19NO3309.3653 / 13.0Yes
18502D structureSMR000009624C16H26N4O2S338.474 / 13.8Yes
19612D structureMLS000082992C16H13FN6S340.386 / 12.7Yes
19702D structureRutaecarpineC18H13N3O287.3222 / 13.0Yes
19742D structureMLS000078748C20H22N4O3366.4217 / 02.6Yes
20182D structureMLS000053810C21H22N2O5382.4165 / 12.7Yes
20362D structureSMR000026069C20H24N2O3S372.4834 / 03.2Yes
20662D structureSMR000046468C25H26N4O4S478.5677 / 14.1Yes
20772D structureASN 04370784C15H12N2O3S2332.3927 / 03.4Yes
21092D structureN-(2-methoxyphenyl)-2-(3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamideC17H17N3O3311.3414 / 31.7Yes
21202D structureSMR000106628C16H21N3O3303.3623 / 00.3Yes
21292D structure2-(4-chloro-2-methylphenoxy)-N-(2-morpholin-4-ylphenyl)acetamideC19H21ClN2O3360.8384 / 13.5Yes
21352D structureMLS000109037C13H16N2OS248.3444 / 02.8Yes
21462D structureNCGC00012161C20H17N3O2331.3755 / 14.0Yes
23702D structureNCGC00012408C21H25N5347.4665 / 03.9Yes
23852D structureAC1MHBGGC20H14F3N5381.3626 / 03.9Yes
5573682D structureSMR000001967C20H21N3O3S383.4666 / 13.9Yes
29132D structure2-[Benzenesulfonyl-(4-fluoro-phenyl)-amino]-N-furan-2-ylmethyl-acetamideC19H17FN2O4S388.4136 / 12.7Yes
31612D structureD-Alanine, 3-sulfino-C3H7NO4S153.1526 / 3-4.2Yes
31682D structureAC1LCKZJC21H26N6O378.485 / 13.4Yes
31882D structure2-{3-[4-(2,4-dichlorobenzyl)piperazin-1-yl]-3-oxopropyl}-1H-isoindole-1,3(2H)-dioneC22H21Cl2N3O3446.3284 / 02.9Yes
32232D structureSMR000006848C18H20N4O308.3854 / 23.3Yes
32432D structure(5-Phenylethynyl-furan-2-yl)-(4-pyridin-2-yl-piperazin-1-yl)-methanoneC22H19N3O2357.4134 / 03.7Yes
32532D structureSMR000000804C21H27N3O3369.4654 / 13.7Yes
32992D structure2,4,6-TrichloronitrobenzeneC6H2Cl3NO2226.4372 / 03.6Yes
33122D structureN-(2,5-dimethoxyphenyl)-2-(5-methyl-1-benzofuran-3-yl)acetamideC19H19NO4325.3644 / 13.4Yes

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