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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NamePlatelet-activating factor receptor
SpeciesHomo sapiens (Human)
GenePTAFR
SynonymPAF receptor
AGEPC receptor
PAF-R
PAFr
DiseaseUnspecified
Thrombocytopenia
Stroke
Solid tumours
Septic shock
[ Show all ]
Length342
Amino acid sequenceMEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
UniProtP25105
Protein Data Bank5zkp, 5zkq
GPCR-HGmod modelP25105
3D structure modelThis structure is from PDB ID 5zkp.
BioLiPBL0417416,BL0417418, BL0417414, BL0417415, BL0417417,BL0417419
Therapeutic Target DatabaseT87023
ChEMBLCHEMBL250
IUPHAR334
DrugBankBE0005561

Known ligands

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Total entries: 587
Page:  / 6 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
7672D structurePhomactin AC20H30O4334.4564 / 21.3Yes
7682D structureCHEMBL2373416C20H30O4334.4564 / 21.3Yes
16062D structureCHEMBL277678C28H18Cl2N6OS557.4535 / 05.1No
16842D structureCHEMBL52933C27H26F2N2O432.5154 / 16.4No
16862D structureCHEMBL54935C27H26F2N2O432.5154 / 16.4No
17362D structureCHEMBL20644C31H26ClN5S536.0944 / 07.1No
22482D structureCHEMBL2113721C33H41BrN2O8S705.6619 / 26.3No
33092D structureCHEMBL290840C34H59N2O5+575.8555 / 09.9No
40502D structureCHEMBL51798C31H39NO8S2617.77210 / 15.1No
41252D structureCHEMBL158974C33H57IN2O6704.7317 / 0N/ANo
48132D structureCHEMBL300644C24H26N2O2S406.5444 / 15.0Yes
57852D structureCHEMBL53014C30H26N2O3462.5494 / 16.2No
58632D structureCHEMBL2304197C17H20Cl2O6391.2416 / 12.5Yes
59702D structureCHEMBL310866C17H12Cl2N2315.1971 / 04.1Yes
5532702D structureCHEMBL326821C20H22ClN3O355.8663 / 02.6Yes
67242D structureCHEMBL278072C30H24ClN5S522.0674 / 06.6No
82862D structureCHEMBL430969C27H28N2O3428.5324 / 15.0Yes
83452D structureCHEMBL106358C28H27N3O3453.5425 / 06.6No
90882D structureCHEBI:5357C20H24O11440.40111 / 4-1.4No
96102D structureCHEMBL37547C18H20BrNO2362.2673 / 04.0Yes
96112D structureCHEMBL291082C18H20BrNO2362.2673 / 04.0Yes
100782D structureCHEMBL79089C21H22N2302.4211 / 04.5Yes
105732D structureCHEMBL320577C28H26N2O3438.5274 / 06.8No
105862D structureCHEMBL80505C16H13N3247.3012 / 01.8Yes
112252D structureCHEMBL160290C28H40N2O8532.6348 / 24.4No
113732D structureCV-6209C34H60ClN3O6642.3197 / 1N/ANo
120472D structureLEXIPAFANTC23H30N4O4S458.5777 / 03.5Yes
137512D structureCHEMBL421843C32H55IN2O6690.7047 / 0N/ANo
137872D structureCHEMBL2304166C28H32O11544.55311 / 21.6No
140812D structureCHEMBL23779C17H21BrO7417.2527 / 21.4Yes
171412D structureCHEMBL2440659C15H11FN4O2S330.3377 / 12.4Yes
178212D structureCHEMBL300742C27H26F2N2O432.5154 / 16.4No
178232D structureCHEMBL299780C27H26F2N2O432.5154 / 16.4No
193762D structureCHEMBL2304169C19H24O7364.3947 / 01.9Yes
204272D structureBB-823C22H30N4O3S430.5676 / 13.3Yes
208282D structureCID 21577214C20H30O3318.4573 / 12.7Yes
211802D structureBDBM50286211C31H31ClN6O4587.0778 / 13.4No
220572D structureCHEMBL20194C28H15F4N5O2529.4559 / 04.1No
234722D structureCHEMBL37643C18H21NO3299.374 / 03.0Yes
245922D structureCHEMBL279084C29H19F4N5O529.4998 / 04.4No
256472D structureCHEMBL118672C27H27N7O2481.566 / 02.6Yes
263612D structureCHEMBL2113730C34H44N2O9S656.79110 / 25.6No
5581182D structureCHEMBL325928C21H19N7O385.4315 / 12.0Yes
307872D structureCHEMBL80130C17H14N2246.3131 / 02.8Yes
334272D structureCHEMBL140919C19H19ClN2O326.8242 / 03.5Yes
347322D structureCHEMBL348609C30H44N2O8560.6888 / 14.9No
351242D structureCHEMBL54068C27H28N2O4444.5315 / 14.4Yes
352922D structureCHEMBL296600C26H34N2O2406.573 / 16.4No
355402D structureCHEMBL293773C31H38O10S2634.75510 / 04.5No
368252D structureCHEMBL52821C26H28N2O384.5232 / 15.6No
388352D structureCHEMBL320871C27H27N3O3441.5315 / 04.3Yes
412792D structureCHEMBL299773C31H36N2O3484.644 / 17.0No
417822D structureCHEMBL286337C28H27ClN4OS503.0615 / 05.0No
421512D structureCHEMBL57480C22H20N4O3388.4275 / 21.8Yes
5534542D structure2-Methyloctadecyl pafC29H60NO7P565.7737 / 08.0No
453762D structureCHEMBL312650C18H16N2260.341 / 03.2Yes
454822D structureCHEMBL20033C28H18ClN5O2491.9355 / 02.7Yes
462132D structureCHEMBL287821C21H28INO4485.3625 / 0N/AN/A
462142D structureCHEMBL34063C21H28INO4485.3625 / 0N/AN/A
5228752D structureCHEMBL3746457C18H15FN4O2338.3425 / 02.2Yes
473162D structureCHEMBL53804C28H30N2O3442.5594 / 15.7No
486242D structureCHEMBL310238C17H13FN2264.3032 / 02.9Yes
494152D structureCHEMBL37952C20H23NO4341.4075 / 03.1Yes
503742D structureCHEMBL283152C29H20FN5O2489.516 / 04.0Yes
504662D structureCHEMBL51696C26H26N2O382.5072 / 15.8No
507632D structureCHEMBL52369C31H38O8S2602.7579 / 05.8No
511962D structureCHEMBL143037C24H26N4O3S450.5576 / 13.0Yes
518962D structureCHEMBL51692C29H36N2O3460.6184 / 16.7No
539602D structureCHEMBL51855C25H32N2O2392.5433 / 15.9No
545742D structureCHEMBL52031C25H28N2O4420.5095 / 14.3Yes
555592D structureCHEMBL282666C28H19FN4O3478.4836 / 03.4Yes
557152D structureCHEMBL56434C23H25N5O2403.4864 / 12.1Yes
565262D structureCHEMBL142433C26H28N4O2428.5364 / 13.7Yes
565272D structureCHEMBL142903C26H28N4O2428.5364 / 13.7Yes
565282D structureCHEMBL57825C26H28N4O2428.5364 / 13.7Yes
583092D structureCHEMBL52615C26H24Cl2N2O451.3912 / 17.0No
586582D structureCHEMBL53149C26H24Cl2N2O451.3912 / 17.0No
597402D structureCHEMBL56418C23H22N4O3402.4545 / 12.1Yes
5535432D structurePca 4248C19H23NO4S361.4566 / 13.6Yes
599172D structureCHEMBL54029C28H30N2O3442.5594 / 15.7No
618292D structureCHEMBL331603C23H25ClN2O380.9162 / 05.3No
626392D structureCHEMBL57489C22H19ClN4O2406.874 / 12.8Yes
626582D structureCHEMBL2304165C17H20Cl2O6391.2416 / 11.9Yes
626592D structureCHEMBL2368435C17H20Cl2O6391.2416 / 11.9Yes
636482D structureCHEMBL217053C18H13BrN2O4401.2165 / 13.5Yes
657242D structureCHEMBL37358C20H22FN3O2355.4135 / 03.0Yes
672002D structureProbes1_000120C21H24N2O2336.4352 / 03.2Yes
688492D structureAzatadine M (nor), acetylatedC21H22N2O318.422 / 03.0Yes
699322D structureCHEMBL280210C30H20ClN5OS534.0345 / 05.5No
727382D structureCHEMBL34548C21H24ClN3O3401.8915 / 03.5Yes
731302D structureCHEMBL300910C32H37NO9S2643.76611 / 04.1No
740042D structureCHEMBL53585C25H28N2O3404.514 / 14.8Yes
748402D structureCHEMBL55071C31H38O9S2618.75610 / 15.5No
751412D structureCHEMBL99294C28H34N2O2430.5923 / 16.8No
776992D structureCHEMBL319384C29H39N3O2461.653 / 16.7No
784402D structureCHEMBL156461C22H28N4OS396.5535 / 12.5Yes
790292D structureCHEMBL301388C22H20F2N2O366.4124 / 14.6Yes
807582D structureSDZ-64-412C28H28N2O3440.5434 / 05.0Yes
810672D structureCHEMBL278635C31H20ClN5OS546.0456 / 04.9No
815632D structureSch-37370C21H21ClN2O352.8622 / 04.4Yes

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