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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesHomo sapiens (Human)
GeneCRHR1
SynonymCRHR
CRH-R1
CRH-R-1
CRFR1
CRFR-1
[ Show all ]
DiseaseMajor depressive disorder; Severe mood disorder
Depression; Anxiety
Depression
Irritable bowel syndrome
Anxiety disorder; Depression
[ Show all ]
Length444
Amino acid sequenceMGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP34998
Protein Data Bank4z9g, 4k5y
GPCR-HGmod modelP34998
3D structure modelThis structure is from PDB ID 4z9g.
BioLiPBL0350036,BL0350037,BL0350038, BL0251208
Therapeutic Target DatabaseT45262
ChEMBLCHEMBL1800
IUPHAR212
DrugBankBE0008658

Known ligands

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Total entries: 1991
Page:  / 20 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1602D structureCHEMBL132055C17H20Cl3N3OS420.7774 / 16.5No
5832D structureCHEMBL1287997C22H26N6O2406.497 / 14.1Yes
6072D structureCHEMBL331539C21H25N5347.4664 / 04.7Yes
22932D structureCHEMBL81376C24H23ClN2O390.9113 / 15.9No
30332D structureCHEMBL352378C19H27ClN4O2378.9016 / 04.7Yes
30882D structureCHEMBL1939595C20H25N3O2339.4393 / 04.4Yes
35422D structureCHEMBL310343C25H27ClN2O406.9543 / 16.3No
37042D structureSCHEMBL1614189C24H33N3O5S475.6048 / 04.1Yes
40742D structureCHEMBL330954C20H25ClN4O372.8974 / 14.4Yes
41712D structureCHEMBL354871C14H16BrN3306.2073 / 04.1Yes
51272D structureCHEMBL303380C19H23Cl2N5392.3284 / 05.3No
54922D structureCHEMBL182624C24H33BrN4O473.4593 / 05.8No
5216302D structureCHEMBL3793159C26H29ClN4O448.9954 / 16.8No
58342D structureCHEMBL65708C16H17N3O267.3323 / 24.0Yes
58982D structureCHEMBL1807021C21H25Cl2N3390.3523 / 16.2No
63062D structureCHEMBL1828896C20H26ClN5O387.9125 / 05.2No
65712D structureCHEMBL430396C25H33N3O391.5593 / 06.2No
65752D structureCHEMBL69968C18H19Cl2N5376.2854 / 14.8Yes
69102D structureCHEMBL3235711C22H31BrN4S463.4825 / 16.9No
72482D structureCHEMBL1819084C20H25ClN4O372.8974 / 15.5No
73982D structureCHEMBL245506C23H28ClN5O2441.965 / 14.2Yes
75032D structureUNII-XBY7Y3DR1JC22H30N4O3398.5076 / 03.9Yes
76252D structureCHEMBL3664600C27H37N3O5S515.6698 / 04.5No
76352D structureCHEMBL68119C16H16ClN3O301.7743 / 24.7Yes
76632D structureUNII-874OEY3JEJC22H26Cl2N4417.3783 / 06.3No
81732D structureCHEMBL1086142C22H28ClF3N4440.9395 / 07.0No
89302D structureCHEMBL464185C22H16F6N6O494.40110 / 14.3Yes
91312D structureCHEMBL2049195C29H37N3O443.6354 / 17.0No
91832D structureCHEMBL187975C30H28F6N4558.5728 / 08.9No
93832D structureCHEMBL1939573C23H30N2334.5071 / 06.8No
94462D structureCHEMBL438724C67H113N17O171428.7419 / 17-2.5No
96902D structureCHEMBL170844C18H23BrN6O2S467.3867 / 03.8Yes
97132D structure195055-03-9C22H32N6380.545 / 04.7Yes
97242D structureCHEMBL1077155C24H34N4O2410.5623 / 04.2Yes
100392D structureCHEMBL1082339C24H24ClF3N4460.9295 / 06.9No
5555182D structureOCRFC205H339N59O63S4670.3871 / 64-19.4No
111112D structureCHEMBL400861C19H29N5O2359.4747 / 23.0Yes
114722D structureCHEMBL2370927C183H307N47O564061.7463 / 55-17.2No
5217742D structureCHEMBL3793845C22H28Cl2N4O435.3934 / 16.8No
115572D structureCHEMBL514717C21H13F6N5O2S2545.47813 / 04.3No
115672D structureCHEMBL381850C23H28N4360.5053 / 04.9Yes
121662D structureCHEMBL2087799C27H35N3O5S513.6538 / 03.6No
123782D structureCHEMBL438888C25H32N2O376.5443 / 06.8No
125562D structureCHEMBL515070C20H16ClN5O2S2457.9517 / 03.5Yes
5218262D structureCHEMBL3794051C23H32N4364.5373 / 16.3No
128832D structureCHEMBL178667C20H31ClN4O2394.9445 / 06.4No
128942D structureCHEMBL197187C21H22ClFN4384.8834 / 04.9Yes
133512D structureCHEMBL185055C24H36N6408.5945 / 05.2No
134092D structureCHEMBL10015C23H24BrF3N4O509.3718 / 06.3No
140992D structureCHEMBL137123C19H27N5325.465 / 15.1No
144272D structureCHEMBL179608C22H28Cl2N4419.3944 / 06.9No
144562D structureCHEMBL65721C16H14F3N3O321.3036 / 24.6Yes
145402D structureCHEMBL496270C18H23Cl2N3O368.3024 / 05.7No
146152D structureCHEMBL81726C21H17BrCl2N2O464.1843 / 16.1No
147852D structureCHEMBL427527C27H26F8N4558.5210 / 08.4No
148382D structureCHEMBL66572C17H13F3N4O346.3137 / 24.3Yes
153102D structureCHEMBL400154C20H30N4O342.4875 / 05.2No
153352D structureCHEMBL184850C22H32N6380.545 / 04.5Yes
155772D structureCHEMBL3235704C20H30N4S358.5485 / 15.6No
158202D structureCHEMBL1939583C21H26ClN3O2387.9083 / 05.6No
159132D structureCHEMBL567382C22H28N8O420.5217 / 24.2Yes
159812D structureCHEMBL1088624C24H30F6N4488.5229 / 06.4No
162272D structureCHEMBL17656C21H28N4O3S416.547 / 03.7Yes
163712D structureCHEMBL2160159C24H30N2O3394.5155 / 05.4No
164302D structureCHEMBL333735C21H24Cl2N4S435.4114 / 06.5No
165832D structureCHEMBL138597C20H20F3N5387.418 / 25.7No
169342D structureCHEMBL391170C27H35N5429.6123 / 07.0No
170052D structureCHEMBL249212C25H28Cl2FN5O504.4317 / 16.1No
170282D structureCHEMBL332721C20H22Cl2N4389.3243 / 05.1No
171572D structureCHEMBL112389C17H13Cl2N302.1981 / 05.8No
171932D structureCHEMBL1836950C21H25N5O363.4655 / 14.5Yes
174142D structureCHEMBL247151C24H28ClN5421.9733 / 06.4No
174902D structureSCHEMBL1613428C26H37N3O5S503.6588 / 04.9No
176692D structureCHEMBL394112C28H28ClN5470.0173 / 06.9No
177322D structureCHEMBL364168C22H31BrN6459.4365 / 05.4No
178002D structureCHEMBL249333C23H29N3O2379.5044 / 04.4Yes
178392D structureCHEMBL83789C21H31N3O3373.4975 / 03.9Yes
179512D structureCHEMBL442773C21H31N7381.5287 / 04.7Yes
182752D structureCHEMBL2087797C28H37N3O5S527.688 / 13.6No
183732D structureCHEMBL179499C25H36N4O408.593 / 05.8No
184472D structureCHEMBL245671C26H30F3N5469.5566 / 06.8No
186852D structureCHEMBL1083822C27H34N4O430.5963 / 05.8No
191542D structureCHEMBL3235715C22H33BrN4O2S497.4967 / 15.3No
192612D structureCHEMBL354367C19H25BrF3N5O476.3429 / 06.7No
192792D structureCHEMBL113653C26H34N2374.5722 / 07.6No
192892D structureCHEMBL1083320C23H25ClF6N4506.9218 / 07.6No
193372D structureCHEMBL181860C20H27N5O353.475 / 14.0Yes
194902D structureCHEMBL362224C25H29N3O387.5274 / 06.6No
196302D structureCHEMBL2370916C211H362N58O664767.5673 / 64-23.3No
196462D structureCHEMBL115119C16H10Cl3N322.6131 / 06.1No
198652D structureCHEMBL302396C23H27N3O3S425.5477 / 04.7Yes
200132D structureCHEMBL248816C23H28N4O376.5045 / 15.7No
204522D structureCHEMBL360851C24H36N6408.5945 / 05.5No
209972D structureCHEMBL334237C21H28N4O2368.4815 / 14.9Yes
209992D structureCHEMBL108673C20H27BrN4403.3683 / 05.6No
214672D structureCHEMBL353973C17H22BrIN4489.1994 / 05.5No
215242D structureCHEMBL297868C19H21Cl2N5390.3124 / 05.5No
216442D structureSCHEMBL1614465C23H31N3O5S461.5778 / 03.7Yes
216632D structureCHEMBL136596C22H27N5361.4935 / 15.8No
217492D structureCHEMBL462789C20H16ClN5OS409.8926 / 04.2Yes

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