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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Known ligands

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Total entries: 1028
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
3362D structureBDBM50442547C104H138N24O151964.420 / 196.9No
8682D structureCHEMBL324028C21H23N3O3365.4333 / 12.1Yes
16682D structureCHEMBL16994C23H25ClN4O3S472.9885 / 02.9Yes
17932D structureCHEMBL343817C18H19FN4310.3764 / 13.9Yes
40182D structureCHEMBL423720C16H18N6294.3625 / 11.7Yes
43742D structureCHEMBL523330C24H31N3O3S441.594 / 14.2Yes
49042D structureCHEMBL1784127C22H20F2N4O394.4265 / 12.3Yes
52272D structureCHEMBL523945C17H13F2N5S357.3837 / 12.5Yes
55712D structureCHEMBL522183C23H21F2N3377.4394 / 14.2Yes
57282D structureCHEMBL495625C24H22N4O4430.4646 / 12.8Yes
65362D structureCHEMBL117400C29H33FN4O3S536.6667 / 24.0No
66782D structureCHEMBL498396C19H16FN3O2337.3545 / 13.5Yes
67262D structureCHEMBL7147C15H14N4250.3052 / 22.2Yes
71772D structureCHEMBL136974C19H19F3N4360.3846 / 14.7Yes
75662D structureCHEMBL269561C17H14FN3279.3183 / 13.1Yes
76442D structureCHEMBL494174C21H17F2N3349.3854 / 23.4Yes
79142D structureCHEMBL349328C38H49IN4O2720.745 / 08.2No
85702D structureCHEMBL326736C14H11N3221.2632 / 12.3Yes
85982D structureCHEMBL331319C28H32F2N4O3S542.6468 / 33.7No
86392D structureCHEMBL523715C24H25N5O3S463.5566 / 12.2Yes
87372D structureCHEMBL75827C23H19F3N4O2S472.4868 / 25.0Yes
88712D structureCID 73351118C184H287N53O53S24153.7661 / 58-13.6No
89832D structureCHEMBL137786C19H18N4O318.384 / 23.8Yes
90412D structureCHEMBL133032C18H19N3O293.374 / 04.1Yes
91632D structureCHEMBL350379C28H35N3O2S477.6675 / 24.9Yes
92392D structureCID 76335489C177H272N52O554008.4362 / 60-15.6No
94792D structureBDBM50261952C23H25BrO4445.3534 / 04.1Yes
100972D structureCHEMBL6938C19H18N2O290.3662 / 14.0Yes
106062D structureCHEMBL288355C28H33N5O3487.6044 / 52.9Yes
114112D structureCHEMBL1912066C19H24N4O4S3468.6058 / 23.1Yes
114372D structureCHEMBL42747C30H35N5O3513.6424 / 43.1No
119382D structureCHEMBL120117C15H10F3N3289.2615 / 13.2Yes
120452D structureCHEMBL1909718C16H24N4O2S2368.5147 / 22.8Yes
121452D structureAc-Peptide YY(25-36)C74H118N26O181659.9237 / 314.7No
131032D structureCHEMBL61879C16H13F3N2O306.2884 / 13.9Yes
138722D structureCHEMBL2440903C41H56N12O7828.9769 / 11-1.2No
141622D structureCID 44577739C27H34O4422.5654 / 15.8No
146272D structureCHEMBL360671C22H23BrF3N5O3S574.41711 / 15.6No
146312D structureD0P9KPC180H279N53O544049.5361 / 61-14.9No
152712D structureCHEMBL304896C22H19N3O2357.4133 / 12.7Yes
153552D structureCHEMBL419951C20H23N3O2337.4232 / 12.9Yes
163062D structureCHEMBL349486C27H30ClN3O5S544.0636 / 23.2No
166072D structureCHEMBL276322C23H24ClN3O4S473.9725 / 22.6Yes
191092D structureCHEMBL506163C22H18FN5O387.4186 / 12.6Yes
191612D structureCHEMBL59680C21H25N3O2351.453 / 12.4Yes
193472D structureCHEMBL492375C25H26N4O3S462.5685 / 12.8Yes
193582D structureCHEMBL118931C29H37N3O3S507.6936 / 24.9No
193952D structureCHEMBL523819C22H15F2N3359.384 / 13.8Yes
199992D structureCHEMBL164586C29H38N4O2S506.7096 / 34.6No
202512D structureCHEMBL76512C18H12Cl2F3N3O414.2095 / 15.6No
207062D structureCHEMBL1912074C13H19N3O2S3345.4947 / 22.8Yes
210942D structureCHEMBL137638C16H24N4272.3963 / 13.9Yes
213452D structureCHEMBL1782077C21H18F2N4O380.3995 / 11.9Yes
215252D structureCHEMBL420541C18H11Cl2N3340.2072 / 14.9Yes
220252D structureCHEMBL1836319C18H24FN3O2S2397.5277 / 23.9Yes
225802D structureCHEMBL525543C20H19N3O3349.395 / 13.4Yes
226522D structureCHEMBL312169C21H26FN3O3S419.5157 / 13.1Yes
233732D structureCHEMBL311159C23H23N3O5421.4535 / 23.7Yes
237492D structureCHEMBL585711C22H26FN5OS2459.6029 / 13.8Yes
237962D structureCHEMBL159134C16H12ClN3O297.7422 / 23.7Yes
240672D structureCHEMBL119726C22H27N3O2365.4772 / 13.6Yes
243372D structureCHEMBL495169C24H25N5O3S463.5566 / 12.5Yes
248952D structureCHEMBL1912087C18H23N5O2S3437.5959 / 23.8Yes
256792D structureCHEMBL425012C23H24BrF3N4O3S573.42910 / 26.1No
266572D structureCHEMBL16986C22H18ClF4N3O3S515.9088 / 14.3No
266902D structureCHEMBL116210C22H19N3O2357.4133 / 13.2Yes
287662D structureCHEMBL1912067C14H17F3N4O2S2394.43110 / 23.3Yes
294092D structureCHEMBL137360C20H24N4320.443 / 14.7Yes
305272D structureCHEMBL278677C26H23N5O2S469.5637 / 34.7Yes
306512D structureCHEMBL312739C24H26N2O2374.4842 / 24.3Yes
308042D structureCHEMBL160722C22H23N3O2361.4453 / 24.1Yes
309392D structureCHEMBL526084C22H18ClN3O4423.8535 / 13.6Yes
312002D structureCHEMBL16965C26H23N5O2S469.5637 / 34.7Yes
312542D structureCHEMBL165506C29H37N3O3S507.6936 / 25.0No
313422D structureCHEMBL418546C23H25ClN4O4S488.9876 / 22.0Yes
314942D structureCID 9930634C24H28O5396.4835 / 13.6Yes
315792D structureCHEMBL417225C20H16N4312.3762 / 13.8Yes
316042D structureCID 44439571C81H123N27O181763.0523 / 29-2.0No
321502D structureCHEMBL304245C17H15F3N2O320.3155 / 13.9Yes
329672D structureCHEMBL521862C20H15F2N3335.3584 / 13.0Yes
338192D structureBDBM50261898C23H25FO4384.4475 / 03.5Yes
338382D structureCHEMBL77589C24H26N2O2374.4842 / 15.6No
338492D structureCHEMBL292729C21H25N3O335.4512 / 13.3Yes
338922D structureCHEMBL167860C27H39N3O4S501.6867 / 33.0No
350882D structureCHEMBL1774211C57H65F3N8O71031.1912 / 6N/ANo
366482D structureCHEMBL277551C24H25N5O2S447.5577 / 34.8Yes
370362D structureCID 9886706C25H26O4390.4794 / 14.3Yes
374242D structureCHEMBL6893C15H13N3235.292 / 12.7Yes
376022D structureCHEMBL418459C20H23N3O2337.4233 / 12.7Yes
377032D structureCHEMBL3040658C84H116N18O161633.9618 / 172.5No
381672D structureCHEMBL489726C20H16F2N4O366.3725 / 22.3Yes
382152D structureCHEMBL123410C22H24Cl2N2O403.3472 / 05.4No
383542D structureCHEMBL294560C20H16N4312.3762 / 14.1Yes
386342D structureSCHEMBL14994383C23H26O4366.4574 / 13.6Yes
386352D structureAC1OF52RC23H26O4366.4574 / 13.6Yes
386402D structureCHEMBL491762C23H26O4366.4574 / 13.6Yes
389612D structureCHEMBL117684C22H21N3O343.432 / 13.6Yes
394412D structureCHEMBL138172C20H22N4O334.4234 / 13.5Yes
403402D structureCHEMBL521844C21H15ClF2N2368.8123 / 14.7Yes
404382D structureCHEMBL137102C22H30N4350.513 / 26.5No

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