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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameHistamine H3 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtQ9QYN8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4124
IUPHAR264
DrugBankN/A

Known ligands

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Total entries: 1879
Page:  / 19 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
6172D structureCHEMBL561028C24H27NO345.4862 / 04.5Yes
6182D structureCHEMBL565206C24H27NO345.4862 / 04.5Yes
7382D structureCHEMBL1085560C24H26N4370.54 / 04.5Yes
7872D structureCHEMBL60435C23H33N3O3399.5355 / 11.8Yes
10582D structureCHEMBL420892C14H16N2O3260.2934 / 12.2Yes
17852D structureciproxifanC16H18N2O2270.3323 / 12.5Yes
22042D structureCHEMBL458722C26H38N2378.6042 / 06.3No
29362D structureBDBM50070217C15H17BrN4O3381.235 / 21.9Yes
29582D structureCID 44370594C14H21N3O6327.3377 / 4N/AN/A
30192D structureUNII-10521U3EQAC23H31NO3S401.5654 / 04.2Yes
4418322D structureCHEMBL3417505C20H27N3O2341.4554 / 12.8Yes
37772D structureCHEMBL125751C18H16N2O2292.3383 / 13.4Yes
40922D structureCHEMBL1829483C19H22N4O2338.4115 / 12.3Yes
43782D structureCHEMBL1086514C27H27N3O409.5334 / 05.0Yes
44032D structureVUF-5649C12H17ClN2S256.7922 / 13.7Yes
47992D structureCHEMBL1084616C21H22N6358.4495 / 03.3Yes
49702D structureCHEMBL12494C15H19N3O257.3372 / 21.9Yes
52962D structureCID 44323707C15H22N2O5310.356 / 3N/AN/A
54452D structureCHEMBL1934527C25H33NO3S427.6034 / 04.8Yes
57782D structureCHEMBL161202C29H36FN5O5553.6359 / 14.4No
59852D structureCHEMBL1171886C21H24ClN3O2385.8924 / 03.9Yes
64982D structureCHEMBL128585C17H21N3O2299.3743 / 22.7Yes
71982D structureCHEMBL563696C22H30N2O2S386.5544 / 14.5Yes
71992D structureCHEMBL563696C22H30N2O2S386.5544 / 14.5Yes
74982D structureCHEMBL158056C27H34FN5O5527.5979 / 13.9No
81032D structureCHEMBL1934066C23H31N321.5081 / 06.7No
81802D structureCHEMBL2013044C24H36N2O4S448.6226 / 03.8Yes
84142D structureCHEMBL458507C26H36N2O392.5872 / 05.4No
84182D structureCHEMBL346711C31H37ClFN5O4598.1168 / 16.1No
85222D structureCHEMBL60143C31H41N3O5535.6856 / 14.4No
85532D structureCID 44323688C11H18N2O5258.2746 / 3N/AN/A
90122D structureCHEMBL27545C26H34N2O3422.5694 / 04.3Yes
90622D structureCHEMBL3092827C21H25N3O2351.454 / 13.1Yes
94542D structureSCHEMBL3778815C13H21N5O2279.3446 / 21.3Yes
98072D structureCarcinineC8H14N4O182.2273 / 3-1.5Yes
99052D structureCHEMBL415989C22H28N6O4440.5046 / 41.9Yes
105552D structureSCHEMBL7976815C10H16N2O180.2512 / 11.3Yes
112062D structureCHEMBL196467C19H22N4O322.4125 / 13.3Yes
116552D structureBDBM50091375C15H19N3O2273.3364 / 12.5Yes
117962D structurecimetidineC10H16N6S252.344 / 30.4Yes
118732D structureCHEMBL457006C21H28N2308.4692 / 04.1Yes
123392D structureCHEMBL161565C29H36FN5O4537.6368 / 14.2No
123542D structureCHEMBL159281C23H25N3O359.4734 / 04.2Yes
123562D structureCHEMBL159648C23H25N3O359.4734 / 04.2Yes
126882D structureCHEMBL179263C22H22ClNO2367.8733 / 05.5No
128562D structureCHEMBL402296C26H30F2N2408.5374 / 05.0Yes
130192D structureCHEMBL246679C23H22N2326.4432 / 15.1No
134392D structureCHEMBL423473C15H17IN2O2384.2173 / 13.1Yes
134962D structureCHEMBL1086292C24H25N3S2419.6055 / 05.9No
145582D structureCHEMBL1935105C20H26F3N3O2397.4427 / 03.5Yes
146462D structureCHEMBL1945848C25H28N4O2416.5255 / 03.7Yes
147502D structureCHEMBL248155C24H24N2340.472 / 05.7No
147532D structureCHEMBL247505C24H24N2340.472 / 05.7No
147542D structureCHEMBL395190C24H24N2340.472 / 05.7No
148092D structureCHEMBL1950743C21H29N3O2355.4824 / 13.3Yes
151462D structureCHEMBL66388C21H29N3323.4843 / 14.8Yes
154102D structureCHEMBL277227C14H15IN2O2370.193 / 12.8Yes
155832D structureCHEMBL559445C23H27N3345.493 / 04.9Yes
157622D structureCHEMBL20191C13H13IN2O2356.1633 / 13.3Yes
158492D structureCHEMBL161130C27H32N2O3432.5644 / 04.6Yes
160102D structureCHEMBL495611C22H31N3O3385.5084 / 13.0Yes
160112D structureCHEMBL61729C12H20N2192.3061 / 14.2Yes
160132D structure(1H-imidazol-4-yl)-1-noneneC12H20N2192.3061 / 14.2Yes
162852D structureCHEMBL64479C23H36N2O3388.5524 / 04.0Yes
166392D structureCHEMBL60559C24H31N3O3S441.596 / 12.5Yes
169782D structureCHEMBL257919C13H19N189.3021 / 03.1Yes
173172D structureCHEMBL112576C9H8N4O2S236.2495 / 11.2Yes
174582D structureCHEMBL1951056C20H30N2O3346.4715 / 02.6Yes
174632D structureCHEMBL1951055C20H30N2O3346.4715 / 02.6Yes
174642D structureSCHEMBL931469C20H30N2O3346.4715 / 02.6Yes
179902D structureCHEMBL2031471C23H31N3O2381.524 / 03.8Yes
180362D structureCHEMBL324890C10H12N4188.2343 / 21.3Yes
180452D structureCHEMBL27835C27H37N3O2435.6124 / 04.5Yes
181062D structureCHEMBL1950740C21H28N4O2368.4815 / 03.0Yes
181102D structureCHEMBL18884C14H18N4O258.3253 / 30.8Yes
181112D structureAC1OYVT5C14H18N4O258.3253 / 30.8Yes
184532D structureCHEMBL161279C30H31FN6O4558.6149 / 13.5No
185272D structureCHEMBL178853C23H25NO2347.4583 / 04.9Yes
187412D structureCHEMBL1823405C20H26N4O338.4554 / 02.6Yes
190452D structureCHEMBL347909C31H38FN5O5579.6739 / 25.1No
191672D structureCHEMBL127901C17H22N2O2286.3753 / 13.4Yes
194142D structureCHEMBL564803C27H30N2O2S446.6094 / 05.0Yes
194152D structureCHEMBL564803C27H30N2O2S446.6094 / 05.0Yes
197232D structureCHEMBL131021C20H24N2O6388.427 / 3N/AN/A
199252D structureCHEMBL124864C11H11BrN2O267.1262 / 12.6Yes
199722D structureCHEMBL3092823C22H25N3O2363.4614 / 03.0Yes
202622D structureCHEMBL25126C26H34N2O3422.5694 / 04.4Yes
202932D structureCHEMBL135410C16H23ClN4O2338.8365 / 22.3Yes
204792D structureCHEMBL1084383C21H23N5S377.515 / 04.4Yes
207492D structureCHEMBL1823410C21H26N4O2366.4654 / 02.0Yes
207752D structureCHEMBL1923732C20H26N2O2326.443 / 03.3Yes
4425102D structureCHEMBL3331158C25H39N3O3429.6055 / 04.4Yes
215702D structureCHEMBL109498C14H15F3N2268.2834 / 14.1Yes
224052D structureCHEMBL2013045C23H34N2O4S434.5956 / 03.4Yes
224382D structureCHEMBL403052C14H21N203.3291 / 03.5Yes
224402D structureCHEMBL257911C14H21N203.3291 / 03.5Yes
230102D structureConessine analogue, 12dC31H41N3O471.6893 / 05.7No
233912D structureCHEMBL112504C10H10N4O2S250.2765 / 11.7Yes
236462D structureCHEMBL1951061C22H34N2O3374.5255 / 03.2Yes
241292D structureCHEMBL1085397C26H27ClN4430.983 / 06.0No

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