Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	protriptyline
Molecular formula	C19H21N
IUPAC name	N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine
Molecular weight	263.384
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	4.4
Synonyms	DTXSID0023535 LS-60771 N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine NCGC00015851-07 PDSP2_001374 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride SBI-0050947.P002 ACM438608 Vivactil BPBio1_000924 CHEBI:8597 Concordin HSDB 3391 methyl(3-{tricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl}propyl)amine NCGC00015851-02 Novo-Doxepin 1225-55-4 (HYDROCHLORIDE) Prestwick2_000930 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene Protriptylinum 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene Triadapin 5 AN-5942 Vivactyl BSPBio_000840 D08447 Lopac-P-8813 N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine NCGC00015851-05 NSC169912 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine Protriptilina [INN-Spanish] 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl- PROTRYPTYLINE HYDROCHLORIDE AC-15971 Triptyl BDBM50176062 CAS-1225-55-4 EINECS 207-119-9 Maximed N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine NCGC00024439-03 Prestwick0_000930 438-60-8 Protriptyline (INN) 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl- SCHEMBL34267 AKOS015962184 Vivactil (Salt/Mix) BRD-K42098891-003-03-1 Concordin (Salt/Mix) Impril MK 240 NCGC00015851-03 Novo-Tripramine 3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine Prestwick3_000930 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene Protriptylinum [INN-Latin] AB00489964 Triptil Apo-Imipramine ZINC1530764 BWPIARFWQZKAIA-UHFFFAOYSA-N DB00344 Lopac0_000974 N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine NCGC00015851-06 PDSP1_001390 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine # Protriptylin 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl- Rhotrimine AC1L1JCC UNII-4NDU154T12 BIDD:PXR0157 CCG-205054 CHEMBL668 GTPL7285 MCULE-6023848462 NCGC00015851-01 Normethyl EX4442 Prestwick1_000930 4NDU154T12 Protriptyline [INN:BAN] 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl- SPBio_003019 Amimetilina Vivactil (TN) BRN 2217411 D00MYQ L000913 MK-240 NCGC00015851-04 Novopramine 3-(11H-dibenzo[[?],[?]][7]annulen-11-yl)-N-methyl-propan-1-amine Protriptilina Protryptyline AB00489964_10 Triptil hydrochloride Apo-Trimip C07408 [ Show all ]
Inchi Key	BWPIARFWQZKAIA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
PubChem CID	4976
ChEMBL	CHEMBL668
IUPHAR	N/A
BindingDB	50176062
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
443036	Adenosine receptor A3	P0DMS8	ADORA3	Homo sapiens (Human)	318
459522	Beta-2 adrenergic receptor	P07550	ADRB2	Homo sapiens (Human)	413
34623	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
34624	Histamine H1 receptor	P31390	Hrh1	Rattus norvegicus (Rat)	486
34622	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218