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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
drd5_human G348 drd5_human I358 drd5_human L354
drd5_human F341 drd5_human F344 drd5_human F347
drd5_human P356 drd5_human S352 drd5_human S353
drd5_human W346 drd5_human W349 drd5_human Y359
drd5_human V343 drd5_human V345 drd5_human V357
drd5_human L88F  [Orientation Restraint] drd5_human N351D agtra_rat V29H
agtra_rat I193P agtra_rat L195P agtra_rat L195S
agtra_rat T198I agtra_rat I193K agtra_rat L195R
ccr5_human N57 ccr5_human C58 ccr5_human L103
ccr5_human L104 cxcr4_human A98 cxcr4_human D97
cxcr4_human V99 ccr5_human L33A ccr5_human L55A  [Orientation Restraint]
ccr5_human L69A  [Orientation Restraint] ccr5_human D76A  [Orientation Restraint] ccr5_human F79A  [Orientation Restraint]
ccr5_human W86A  [Orientation Restraint] ccr5_human L104A ccr5_human T105A  [Orientation Restraint]
ccr5_human Y108A  [Orientation Restraint] ccr5_human F112A  [Orientation Restraint] ccr5_human F113A  [Orientation Restraint]
ccr5_human T123A  [Orientation Restraint] ccr5_human F144A  [Orientation Restraint] ccr5_human N252A  [Orientation Restraint]
ccr5_human N258A ccr5_human T259A ccr5_human M279A
ccr5_human E283A ccr5_human H289A ccr5_human N293A
ccr5_human Y297A nk1r_human I204H  [Orientation Restraint] nk1r_human A115V  [Orientation Restraint]
nk1r_human T201I nk1r_human F268W  [Orientation Restraint] nk1r_human A294V  [Orientation Restraint]
nk1r_human G166C  [Orientation Restraint] nk1r_human Y167F  [Orientation Restraint] nk1r_human I204A  [Orientation Restraint]
nk1r_human L203A  [Orientation Restraint] 5ht4r_human N279L 5ht4r_human F276V  [Orientation Restraint]
5ht4r_human P149A  [Orientation Restraint] 5ht4r_human S197A  [Orientation Restraint] ccr5_human R31G
nk1r_human C152V  [Orientation Restraint] nk1r_human C199V nk1r_human C306S
nk1r_human C307S nk1r_human C306A nk1r_human C307F
nk1r_human H197V adrb2_human S204C  [Orientation Restraint] drd2_human V154C  [Orientation Restraint]
drd2_human S157C  [Orientation Restraint] drd2_human I158C  [Orientation Restraint] drd2_human V161C  [Orientation Restraint]
drd2_human F164C  [Orientation Restraint] drd2_human T165C  [Orientation Restraint] drd2_human P169C  [Orientation Restraint]
drd2_human L171C  [Orientation Restraint] drd2_human G173C  [Orientation Restraint] ccr2_human E291A
ccr2_human E291Q ccr2_human E291K pe2r2_human L90F  [Orientation Restraint]
tshr_human R418V tshr_human L417V tshr_human K415C
tshr_human F416G tshr_human Y414N 5ht4r_human D66N  [Orientation Restraint]


Reference:

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