Home Research Services Publications People Teaching Job Opening Facilities News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind DockRMSD

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameNeuromedin-K receptor
SpeciesHomo sapiens (Human)
GeneTACR3
SynonymSP-N receptor
Tac3r
Nmkr
NKR
NK3 receptor
[ Show all ]
DiseaseSchizophrenia
Schizophrenia; Schizoaffective disorders
Psychotic disorders
Psychiatric disorder
Irritable bowel syndrome
[ Show all ]
Length465
Amino acid sequenceMATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
UniProtP29371
Protein Data BankN/A
GPCR-HGmod modelP29371
3D structure modelThis predicted structure model is from GPCR-EXP P29371.
BioLiPN/A
Therapeutic Target DatabaseT29683
ChEMBLCHEMBL4429
IUPHAR362
DrugBankBE0002371

Known ligands

You can:

Total entries: 1136
Page:  / 12 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
142D structureCHEMBL1760216C20H21N5O2363.4215 / 12.2Yes
3972D structureCHEMBL3288163C34H39Cl3FN5O4707.0657 / 4N/ANo
10682D structureCHEMBL2113679C27H27N3O2425.5324 / 24.6Yes
24902D structureSubstance PC63H98N18O13S1347.6517 / 15-2.3No
28012D structuresub-stance pC63H98N18O13S1347.6517 / 15-2.3No
32012D structureCHEMBL26790C33H36Cl2N4O2591.5773 / 16.1No
34492D structureCHEMBL1084165C29H30ClF6N3O3618.01711 / 26.2No
5360272D structureSCHEMBL1993496C31H30ClFN6O3589.0688 / 04.6No
52142D structureCHEMBL298272C32H47N3O5553.7445 / 45.6No
52182D structureCHEMBL296014C32H47N3O5553.7445 / 45.6No
52202D structureCHEMBL430576C32H47N3O5553.7445 / 45.6No
55962D structureCHEMBL221077C30H30N4O3494.5955 / 15.5No
58612D structureCHEMBL3648215C24H20Cl2N4O2467.355 / 04.7Yes
72272D structureCHEMBL1760331C21H20Cl2N4O2431.3174 / 14.5Yes
77182D structureCHEMBL1682628C33H37Cl2N3O2578.5783 / 15.9No
78742D structureCHEMBL1682682C31H39Cl2FN4O2589.5775 / 05.0No
4420752D structureCHEMBL3421991C23H18ClN5O415.8814 / 03.0Yes
93482D structureCHEMBL3680211C31H31ClFN3O4564.0545 / 05.5No
94092D structureCHEMBL1760214C20H21N5O2363.4215 / 12.2Yes
5362422D structureSCHEMBL1990036C31H33F3N4O5S630.68310 / 04.2No
5217442D structureCHEMBL3735396C41H57N7O11S856.00512 / 81.5No
5217482D structureCHEMBL3735210C41H57N7O11S856.00512 / 81.5No
5362822D structureCHEMBL3940252C23H19N5OS413.4995 / 03.3Yes
5363112D structureSCHEMBL1984740C27H30ClF2N3O4534.0016 / 03.9No
5218272D structureCHEMBL3736313C40H56N8O11S856.99313 / 9-2.0No
130012D structureCHEMBL3680187C32H32ClFN4O3575.0816 / 05.7No
5218502D structureCHEMBL3814985C25H20N2OS396.5083 / 05.8No
137722D structureAprepitantC23H21F7N4O3534.43512 / 24.2No
5576812D structureCHEMBL3813735C25H22N2O3398.4624 / 35.4No
5218942D structureCHEMBL3814793C26H24N2O3412.4894 / 25.7No
5363752D structureSCHEMBL1989445C31H37ClFN3O5586.1016 / 04.1No
5480632D structureCHEMBL3984151C17H17FN6O2356.3617 / 01.4Yes
5577312D structureSCHEMBL16143091C17H17FN6O2356.3617 / 01.4Yes
5363942D structureCHEMBL3942295C17H17FN6O2356.3617 / 01.4Yes
161712D structureCHEMBL2347498C53H75N13O14S21182.3818 / 13-2.7No
165392D structureCHEMBL75478C38H44Cl4N6O5806.6077 / 17.1No
166662D structureCHEMBL47775C32H42N4O498.7154 / 16.4No
169002D structureCHEMBL78851C35H37Cl4N5O5749.5117 / 07.4No
172322D structureSCHEMBL1973042C27H31Cl3N4O3565.923 / 14.4No
172562D structureSCHEMBL6837152C29H29Cl2F3N4O2593.4728 / 06.5No
174862D structureSCHEMBL6837264C27H24Cl2N4O3523.4146 / 06.0No
175642D structureELEDOISINC54H85N13O15S1188.4117 / 14-3.6No
5364442D structureSCHEMBL1988590C31H30Cl2F4N4O3653.59 / 06.9No
178112D structureCHEMBL1911964C30H28F7N3O3611.56111 / 25.1No
178612D structureCHEMBL282728C26H24N2O4428.4884 / 24.5Yes
190392D structureCHEMBL1682666C33H37Cl2N3O2578.5783 / 05.7No
196222D structureCHEMBL375640C25H20FN3O4445.456 / 14.9Yes
198682D structureCHEMBL32301C25H30N4O4450.5394 / 43.0Yes
4424472D structureCHEMBL71498C17H21NO255.3612 / 12.9Yes
4424722D structureCHEMBL3361403C21H25N3O4383.4485 / 3-0.5Yes
209172D structureCHEMBL45278C29H34N2O3458.6023 / 26.2No
209182D structureCHEMBL44686C29H34N2O3458.6023 / 26.2No
211892D structureCHEMBL1682629C33H37Cl2N3O3594.5774 / 15.5No
215302D structureCHEMBL1682640C32H33Cl4N3O2633.4353 / 16.8No
5365272D structureSCHEMBL1990943C30H32ClFN4O4567.0586 / 04.1No
217252D structureCHEMBL307733C34H39Cl4N5O4723.5176 / 07.0No
219392D structureCHEMBL1682670C32H36Cl2N4O2579.5663 / 25.3No
5533452D structureFK 224C54H72N8O131041.2113 / 104.9No
5221382D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5221982D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
5365682D structureCHEMBL3964222C21H17N5OS2419.5216 / 03.0Yes
5580012D structureSCHEMBL16115678C17H14F4N6O2410.33310 / 01.9Yes
5481542D structureCHEMBL3898651C17H14F4N6O2410.33310 / 01.9Yes
237072D structureCHEMBL1682637C33H34Cl2F3N3O2632.5496 / 16.4No
242672D structureTalnetantC25H22N2O2382.4633 / 25.7No
242742D structureCHEMBL430118C25H22N2O2382.4633 / 25.7No
242762D structureSB 223412C25H22N2O2382.4633 / 25.7No
245512D structureCHEMBL33868C36H42N4O546.7594 / 17.0No
245652D structureCHEMBL3288170C39H45Cl2F4N5O6826.71212 / 3N/ANo
254372D structureCHEMBL3680182C25H28ClFN2O4474.9575 / 04.0Yes
5366502D structureSCHEMBL1985493C31H31ClF4N4O3619.0589 / 06.3No
5580562D structureSCHEMBL1987661C31H31ClF4N4O3619.0589 / 06.3No
257022D structureCHEMBL3104771C26H35N3O3437.5844 / 23.5Yes
257372D structureCHEMBL2114308C27H26N2O3426.5163 / 25.3No
257382D structureCHEMBL278351C27H26N2O3426.5163 / 25.3No
5481732D structureCHEMBL3984131C24H23N5OS429.5425 / 03.7Yes
5580702D structureSCHEMBL14850857C24H23N5OS429.5425 / 03.7Yes
262792D structureCHEMBL1682673C31H35Cl2N3O3S600.5995 / 15.3No
4427192D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
278282D structureCHEMBL2347501C50H71N11O17S1130.2419 / 14-4.6No
284602D structureCHEMBL2347505C55H85N13O17S1232.4219 / 15-4.5No
4427962D structureCHEMBL3361402C32H45N5O6S627.8018 / 50.9No
5367382D structureSCHEMBL1986618C33H41ClFN3O5614.1556 / 04.7No
307212D structureCHEMBL1682939C26H24N2O2S428.554 / 14.7Yes
307222D structureCHEMBL1682938C26H24N2O2S428.554 / 14.7Yes
5582422D structureCHEMBL3813719C25H22N2O3398.4624 / 35.4No
324642D structureCHEMBL1760210C22H24N4O2376.464 / 13.6Yes
327692D structureSCHEMBL6837110C27H24Cl2N4O3523.4146 / 06.0No
5368542D structureSCHEMBL1990795C30H29F3N6O3578.59610 / 04.0No
4429592D structureUNII-7W7511NPF8C20H20N2O3S368.4516 / 11.8Yes
340952D structureCHEMBL3680200C30H31ClF2N4O3569.057 / 05.7No
5368752D structureSCHEMBL1990051C33H36ClFN4O4607.1237 / 05.5No
4430432D structureCHEMBL3422010C21H19N5OS2421.5376 / 03.0Yes
4430502D structureCHEMBL3422011C21H19N5OS2421.5376 / 03.0Yes
349092D structureCHEMBL1760207C23H24ClN3O2409.9143 / 14.4Yes
350082D structureCHEMBL50905C25H22N2O2382.4633 / 14.9Yes
360082D structureCHEMBL26336C26H21F3N2O3466.466 / 25.4No
5483092D structureCHEMBL3896219C17H15N7OS365.4157 / 01.2Yes
5583802D structureSCHEMBL17005219C17H15N7OS365.4157 / 01.2Yes
361382D structurePD157672C32H47N5O5581.7585 / 54.5No

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218