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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesBos taurus (Bovine)
GeneHTR2A
Synonym5-HT-2A
5-HT-2
Serotonin receptor 2A
DiseaseN/A for non-human GPCRs
Length470
Amino acid sequenceMDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
UniProtQ75Z89
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3446
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 189
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4902D structureCHEMBL54125C22H21FN4360.4364 / 04.7Yes
18652D structureCHEMBL53662C23H23FN4O390.4625 / 04.7Yes
42222D structureCHEMBL25984C15H23NO233.3552 / 03.8Yes
49712D structureCHEMBL50188C25H36N2O4428.5735 / 04.2Yes
55422D structureCHEMBL50722C25H36N2O5444.5726 / 04.3Yes
59192D structureCHEMBL50722C27H38N2O9534.60610 / 2N/ANo
72622D structureCHEMBL54914C15H17N5267.3364 / 02.4Yes
78542D structureCHEMBL63114C14H15N3S257.3553 / 04.2Yes
96142D structureCHEMBL418678C20H19FN4S366.4585 / 04.7Yes
102732D structureCHEMBL298649C22H22FN5375.4515 / 04.3Yes
117322D structurepropranololC16H21NO2259.3493 / 23.0Yes
118122D structureCHEMBL54266C23H32N2O4S432.5796 / 14.3Yes
123022D structureCHEMBL52800C22H22FN5O391.456 / 04.3Yes
136652D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
182102D structureCHEMBL49932C22H21N5O2387.4436 / 03.7Yes
199952D structureCHEMBL53490C14H15N5253.3094 / 11.9Yes
232432D structureDIHYDREXIDINEC17H17NO2267.3283 / 32.5Yes
232872D structureCHEMBL303986C19H23N5OS369.4875 / 03.2Yes
259562D structureCHEMBL62612C22H24N4S376.5224 / 05.4No
266472D structureCHEBI:48565C21H26N2O3354.454 / 22.9Yes
332382D structureCHEMBL410531C22H20ClFN4394.8784 / 05.3No
413142D structureCHEMBL60318C20H22FN3OS371.4745 / 03.9Yes
424112D structureCHEMBL62911C21H23N4S+363.5033 / 04.6Yes
440852D structureCHEMBL50456C21H19Cl2N5412.3184 / 05.1No
452042D structureCHEMBL302225C14H16N4S272.374 / 03.1Yes
539512D structureCHEMBL65736C17H20N4S312.4354 / 03.9Yes
546112D structureCHEMBL48925C25H34N2O4426.5575 / 14.6Yes
566992D structurecisaprideC23H29ClFN3O4465.957 / 23.4Yes
574072D structureCHEMBL298534C24H31FN2O3414.5215 / 14.7Yes
579132D structureCHEMBL53195C32H35N7517.6816 / 05.6No
589992D structureCHEMBL66307C26H23ClN4S459.0084 / 07.0No
592602D structureCHEMBL64167C20H23N3OS353.4844 / 03.8Yes
596952D structureCHEMBL62366C20H20N4S348.4684 / 04.8Yes
622272D structurespiperoneC23H26FN3O2395.4785 / 13.0Yes
623152D structureCHEMBL51888C22H30N2O4S418.5526 / 13.9Yes
625112D structureCHEMBL52438C19H25NO283.4152 / 05.1No
630762D structureCHEMBL11592C26H38N2O4442.65 / 04.6Yes
632692D structureCHEMBL63289C16H18N4O2S330.4065 / 03.4Yes
670372D structureCHEMBL65669C20H20N4S348.4684 / 04.8Yes
689442D structureCHEMBL301060C28H40N2O8532.6349 / 2N/ANo
716302D structureCHEMBL261977C22H22N4S374.5064 / 05.3No
719612D structureCHEMBL62445C19H18N4S334.4414 / 14.3Yes
727422D structureCHEMBL59741C20H20F3N3OS407.4557 / 14.5Yes
781982D structuredomperidoneC22H24ClN5O2425.9173 / 23.9Yes
823372D structureCHEMBL52612C20H22N4318.4243 / 03.0Yes
838902D structureKetanserinC22H22FN3O3395.4345 / 12.6Yes
846862D structureCHEMBL63713C22H21F3N4S430.4937 / 06.0No
880812D structureCHEMBL296395C22H24N2O4380.4445 / 12.9Yes
882682D structureCHEMBL50993C25H36N2O3412.5744 / 04.6Yes
929842D structureCHEMBL300735C24H34N2O4S446.6066 / 14.6Yes
1016352D structure5-Meo-dpacC16H25NO2263.3813 / 03.8Yes
1032312D structureCHEMBL302431C20H18Cl2N4S417.3524 / 05.9No
1123532D structureCHEMBL285010C14H19NO2233.3113 / 02.5Yes
1131622D structureCHEMBL62902C26H21F3N4S478.5377 / 07.4No
1147012D structureCHEMBL63845C20H17F3N4S402.4397 / 05.8No
1206652D structureCHEMBL54089C26H30N2O8498.5329 / 2N/AN/A
1216712D structureCHEMBL294730C22H27N3O2S397.5375 / 04.1Yes
1229182D structureCHEMBL52625C21H20FN5361.4245 / 04.0Yes
1244182D structureCHEMBL104985C14H18ClN3O279.7684 / 03.4Yes
1358902D structureCHEMBL299097C21H21N5343.4344 / 04.0Yes
1360662D structureCHEMBL59823C24H31N3O3409.535 / 03.6Yes
1407322D structureCHEMBL52396C25H30N2O4422.5255 / 04.3Yes
1420522D structureCHEMBL61819C23H29N3O2S411.5645 / 04.4Yes
1423012D structureCHEMBL63790C21H20N4O2S392.4776 / 04.4Yes
1431512D structureCHEMBL545198C23H26N2O4394.4715 / 03.6Yes
1462172D structureGR 103691C30H35N3O3485.6285 / 14.8Yes
1489742D structureCHEMBL63905C19H17FN4S352.4315 / 05.0Yes
1522022D structureCYPROHEPTADINEC21H21N287.4061 / 04.7Yes
1529172D structureCHEMBL51985C27H41N2O4+457.6354 / 04.6Yes
1531182D structureCHEMBL545198C23H27ClN2O4430.9295 / 1N/AN/A
1604432D structureCHEMBL300692C23H23FN4374.4634 / 05.1No
1662592D structureCHEMBL416662C23H21ClN4O2420.8975 / 05.1No
1692802D structureCHEMBL54266C25H34N2O8S522.61310 / 3N/ANo
1733592D structureCHEMBL51985C27H41IN2O4584.5395 / 0N/ANo
1820932D structureCHEMBL52485C24H36N2O4416.5625 / 03.7Yes
1830792D structureCHEMBL293219C26H21F3N4S478.5377 / 07.5No
1893452D structureCHEMBL50841C24H34N2O4414.5465 / 03.9Yes
1915952D structurehaloperidolC21H23ClFNO2375.8684 / 13.2Yes
1949082D structurefluphenazine enanthateC29H38F3N3O2S549.6979 / 07.4No
1964772D structureCHEMBL284912C21H34N2O3362.5145 / 03.3Yes
1987012D structureCGS 12066BC17H17F3N4334.3466 / 04.0Yes
2034892D structureCUMI-101C19H27N5O3373.4576 / 01.8Yes
2083972D structureCHEMBL416747C22H36N2O2360.5424 / 04.5Yes
2119562D structureCHEMBL292293C13H13N3OS259.3274 / 03.0Yes
2127472D structureCHEMBL64727C20H18Cl2N4S417.3524 / 05.9No
2134152D structureCHEMBL62274C16H18N4S298.4084 / 03.8Yes
2283342D structureCHEMBL415933C23H28N6O404.5185 / 03.7Yes
2315482D structureCHEMBL51888C24H32N2O8S508.58610 / 3N/ANo
2405922D structurePhentolamine mesylateC18H23N3O4S377.4596 / 3N/AN/A
2445182D structureA-131701C24H24N4O3S448.5416 / 13.2Yes
2509912D structureCHEMBL292725C21H20N4O2S392.4776 / 04.4Yes
2526522D structureCHEMBL48925C27H36N2O8516.5919 / 3N/ANo
2530422D structureCHEMBL65710C20H20N4S348.4684 / 04.6Yes
2531932D structureCHEMBL51225C20H19N5329.4074 / 04.2Yes
2535042D structureCHEMBL65974C14H16N4S272.374 / 03.1Yes
2546222D structureCHEMBL53416C22H22N4342.4463 / 04.6Yes
2550912D structureCHEMBL298534C26H33FN2O7504.5559 / 3N/ANo
2576812D structureCHEMBL50530C24H34N2O4414.5465 / 03.6Yes
2596042D structureCHEMBL299561C26H38N2O7490.5978 / 2N/AN/A
2665802D structureCHEMBL293879C17H20N4O2S344.4336 / 03.4Yes

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