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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
ste2_yeast A265N ste2_yeast Y266C ste2_yeast Y266D
ste2_yeast Y266W ste2_yeast S267C ste2_yeast L268C
ste2_yeast K269C ste2_yeast P270C ste2_yeast N271C
ste2_yeast Q272C ste2_yeast G273C ste2_yeast T274A
ste2_yeast T274C ste2_yeast D275C ste2_yeast D275V
ste2_yeast V276A ste2_yeast V280D ste2_yeast A281T
ste2_yeast T282A ste2_yeast L284H ste2_yeast S288A
ste2_yeast L289S ste2_yeast S292A ste2_yeast S292Q
ste2_yeast S293A ste2_yeast S293N ste2_yeast A296T
ste2_yeast A299P ste2_yeast G322E ste2_yeast S331A
ste2_yeast K337R ste2_yeast S338A ste2_yeast S338D
ste2_yeast S338E ste2_yeast S339A ste2_yeast S339D
ste2_yeast S339E ste2_yeast T382A ste2_yeast T384A
ste2_yeast S385A ste2_yeast S386A ste2_yeast N388D
ste2_yeast S398A ste2_yeast T411A ste2_yeast T414A
ste2_yeast T425A ste2_yeast N430A ste3_yeast P222F
ste3_yeast P222L ste3_yeast T389A t2r60_human S111A
fzd4_rat M13F fzd9_human S65T friz3_drome T17N
smo_drome C155Y smo_drome S220N bacr_halsa Electron Microscopy 7 TMhelix x-y coordinates 7.99 22.61 14.39 29.79 23.05 28.00 32.36 29.79 36.84 20.29 27.98 11.45 19.89 12.29  [Electron Microscopy]
bacr_halhp Neutron Diffraction 7 TMhelix x-y coordinates 28.98 33.39 35.37 26.20 44.15 22.50 51.66 26.20 49.85 35.85 42.46 33.67 35.49 38.49  [Neutron Diffraction] bacr_halhs Neutron Diffraction 7 TMhelix x-y coordinates 36.72 20.29 28.09 27.33 17.66 30.22 9.46 22.75 12.15 11.44 21.24 15.7430.33 12.01  [Neutron Diffraction] prrg_prb01 Electron Microscopy 7 TMhelix x-y coordinates 6.33 20.28 12.73 23.73 20.24 22.08 27.75 23.60 31.67 16.55 24.17 9.65 18.23 10.63  [Electron Microscopy]
adrb2_human C327R drd1_human S107G  [Orientation Restraint] drd1_human S199V  [Orientation Restraint]
drd1_human D70V  [Orientation Restraint] drd1_human K81E drd1_human C283V  [Orientation Restraint]
drd1_human F319L  [Orientation Restraint] drd2_human M116L  [Orientation Restraint] nk1r_human C152F  [Orientation Restraint]
nk1r_human I290S  [Orientation Restraint] nk1r_rat H197A nk1r_rat A195V
nmbr_rat H234F agtra_rat K199Q cxcr1_human M200A
cxcr1_human V201A cxcr1_human R203A cxcr1_human L202A
cxcr1_human L287A cxcr1_human T290A cxcr1_human K117A
cxcr1_human D85A  [Orientation Restraint] cxcr1_human D288A cxcr1_human E291A
drd2_human C56S  [Orientation Restraint] drd2_human C126S  [Orientation Restraint] drd2_human C168S  [Orientation Restraint]
ednra_human I132A  [Orientation Restraint] agtrb_rat T198A agtrb_rat A277Y
agtrb_rat I276M par1_human Y372A par1_human Y373A


Reference:

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