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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
aa1r_human Y179 aa1r_human Y182 aa1r_human V181
lshr_rat V368H oprd_rat N131 tshr_human N495
tshr_human L452 tshr_human M453 tshr_human M626
tshr_human F451 tshr_human T682 oprk_rat I228
oprd_rat L125 acm1_mouse A419 acm1_mouse N410
acm1_mouse N414 acm1_mouse C407 acm1_mouse C417
acm1_mouse C421 acm1_mouse G403 acm1_mouse L402
acm1_mouse L406 acm1_mouse M416 acm1_mouse P415
acm1_mouse S411 acm1_mouse S420 acm1_mouse T412
acm1_mouse W405 acm1_mouse Y404 acm1_mouse Y408
acm1_mouse Y418 acm1_mouse V409 acm1_mouse V413
cxcr1_human I204 cxcr2_human I213 nk1r_human Y196
adrb2_human A198 adrb2_human A200 adrb2_human Q170
adrb2_human Q197 adrb2_human G35 adrb2_human H172
adrb2_human H93 adrb2_human I94 adrb2_human L95
adrb2_human M171 adrb2_human W173 adrb2_human Y174
adrb2_human Y199 aa1r_bovin Y182 oprk_mouse I61
oprk_mouse P59 oprk_mouse V60 oprd_mouse A47
oprd_mouse L46 tshr_human R418 ednrb_human D241
c5ar_human L256S  [Orientation Restraint] c5ar_human A203 adrb2_mesau S92
crfr1_human K257Q vipr1_human M179 vipr1_human M219V
ssr5_human A101V ssr5_human A273G ssr5_human L272I
ssr2_human A289 ssr2_human D295 ssr2_human G292
ssr2_human L290 ssr2_human K291 ssr2_human M293
ssr2_human F294 ssr2_human S278 ssr2_human V277
acm3_rat V67 acm3_rat V68 cckar_human A42
casr_human E837 casr_human L770 casr_human L861
casr_human F862 casr_human T745 adrb3_human N312A  [Orientation Restraint]
v2r_human A114 v2r_human A179 v2r_human A39
v2r_human R202 v2r_human R203 v2r_human Q180
v2r_human E40 v2r_human G201 v2r_human K116


Reference:

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