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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
glr_rat M232 glr_rat T229 glr_rat Y176
glr_rat V227 glr_rat V230 glr_rat V286
tshr_human M453T glp1r_rat I265 glp1r_rat K267
glp1r_rat F266 glp1r_rat N177A glp1r_rat I265A
glp1r_rat F266A glp1r_rat K267A agtra_rat I124
agtra_rat S123 ghrhr_human A176 ghrhr_human A178
ghrhr_human A207 ghrhr_human A208 ghrhr_human A212
ghrhr_human A222 ghrhr_human A224 ghrhr_human A241
ghrhr_human N216 ghrhr_human Q167 ghrhr_human Q381
ghrhr_human E223 ghrhr_human G177 ghrhr_human H165
ghrhr_human H210 ghrhr_human I173 ghrhr_human I304
ghrhr_human L168 ghrhr_human L174 ghrhr_human L181
ghrhr_human L220 ghrhr_human L221 ghrhr_human L227
ghrhr_human K175 ghrhr_human M214 ghrhr_human F169
ghrhr_human F172 ghrhr_human F180 ghrhr_human F211
ghrhr_human F217 ghrhr_human S205 ghrhr_human S209
ghrhr_human S218 ghrhr_human S262 ghrhr_human S330
ghrhr_human T166 ghrhr_human T170 ghrhr_human T171
ghrhr_human T213 ghrhr_human T215 ghrhr_human W219
ghrhr_human Y163 ghrhr_human Y226 ghrhr_human V164
ghrhr_human V179 ghrhr_human V206 ghrhr_human V225
lshr_rat M575 oprd_mouse L238 tshr_human K415
tshr_human F416 tshr_human Y414 par1_human Y270R  [Orientation Restraint]
ada1d_human M156 aa1r_human E16Q  [Orientation Restraint] aa1r_human S50A  [Orientation Restraint]
aa1r_human S93A  [Orientation Restraint] aa2ar_human H278K  [Orientation Restraint] aa2ar_human H278N  [Orientation Restraint]
aa2ar_human H250N  [Orientation Restraint] galr1_human V201A galr1_human T204A
galr1_human H263A  [Orientation Restraint] galr1_human F282A galr1_human F282Y
galr1_human R285A  [Orientation Restraint] nk1r_human I198A nk1r_human V200A
nk1r_human F268A  [Orientation Restraint] nk1r_human I290A  [Orientation Restraint] aa2ar_human F180A  [Orientation Restraint]
aa2ar_human H250F  [Orientation Restraint] aa2ar_human H250A  [Orientation Restraint] aa2ar_human H250Y  [Orientation Restraint]
aa2ar_human N253A aa2ar_human C254A aa2ar_human F257A


Reference:

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