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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
v2r_human E40 v2r_human G201 v2r_human K116
v2r_human T204 v2r_human Y117 v2r_human Y205
v2r_human V115 ccr5_human R31A mshr_human A164
mshr_human T242 mshr_human V241 mshr_human N91
mshr_human D84 mshr_human G89 mshr_human L85
mshr_human L86 mshr_human S88 mshr_human V87
mshr_human V92 mshr_human G49 mshr_human L46
mshr_human L48 mshr_human L50 mshr_human L53
mshr_human F45 mshr_human S47 mshr_human S52
mshr_human V51 mshr_human L93 mshr_human A81
mshr_human C79 mshr_human L80 mshr_human L82
mshr_human S83 mshr_human A57 mshr_human N56
mshr_human E55 mshr_human L58 mshr_human V54
mshr_human V59 mshr_human V60 mshr_human G43
mshr_human L44 mshr_human L211 mshr_human M210
mshr_human L266 mshr_human A137 mshr_human A139
mshr_human C133 mshr_human G136 mshr_human I138
mshr_human L132 mshr_human L135 mshr_human F134
mshr_human S131 opsd_bovin M309 cnr1_rat W300
cxcr1_rabit N43 cxcr1_rabit L42 cxcr1_rabit K44
cxcr1_rabit T41 cxcr1_rabit C115 cxcr1_rabit L120
cxcr1_rabit K116 cxcr1_rabit K122 cxcr1_rabit S119
cxcr1_rabit V117 cxcr1_rabit V118 cxcr1_rabit V121
cxcr1_rabit R208 cxcr1_rabit L207 cxcr1_rabit M205
cxcr1_rabit V206 cxcr1_rabit D270 adrb2_mesau R151
mshr_human F258A  [Orientation Restraint] mshr_human D121A mshr_human F175A  [Orientation Restraint]
mshr_human Y182A  [Orientation Restraint] mshr_human Y183A mshr_human F195A  [Orientation Restraint]
mshr_human D121N mshr_human D121K mshr_human F280A  [Orientation Restraint]
acm5_human G148S acm5_human G148C acm5_human I149F
acm5_human A147T acm5_human G148R acm5_human I149M
acm5_human A147V acm5_human G148A acm5_human I149T


Reference:

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