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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●COACH ●COFACTOR ●MetaGO ●MUSTER ●CEthreader ●SEGMER ●FG-MD ●ModRefiner ●REMO ●DEMO ●SPRING ●COTH ●Threpp ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●CR-I-TASSER ●GPCR-I-TASSER ●MAGELLAN ●BindProf ●BindProfX ●SSIPe ●ResQ ●IonCom ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

Other GPCR-related resources GPCR-I-TASSER: On-line server for GPCR structure prediction GPCR-HGmod: Structur models of GPCRs in the human genome GPCR-EXP: collection of experimentally solved GPCRs GLASS: GPCR-ligand association database GPCR resources from other laboratories GPCRDB: information system for GPCRss TinyGPAP mutant database GPCR-OKB: oligomerization knowledge base GPCR natural variants database GLIDA: GPCR-ligand database IUPHAR GPCR database gpDB: G proteins and their interactions with GPCRs SEVENS: GPCR genes database GDD: GPCR decoy database Summary of activation changes in GPCR TMs

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11002 entries in GPCR-RD.
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Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data	Swiss-Prot ID	Experimental Data
agtrb_rat	I276M	par1_human	Y372A	par1_human	Y373A
nk1r_rat	C199I	nk1r_rat	T201I	nk1r_rat	V202I
nk1r_rat	L269I	nk1r_rat	A195T	opsg_human	A180S  [Orientation Restraint]
opsg_human	F277Y  [Orientation Restraint]	opsg_human	F309Y  [Orientation Restraint]	opsg_human	F279V  [Orientation Restraint]
opsg_human	I65T  [Orientation Restraint]	opsr_human	Y277F  [Orientation Restraint]	opsr_human	T285A  [Orientation Restraint]
opsr_human	T65I  [Orientation Restraint]	opsr_human	I230T  [Orientation Restraint]	opsr_human	Y309F  [Orientation Restraint]
agtra_rat	K199A	agtra_rat	K199R	agtra_rat	K199E
acm2_human	I389L  [Orientation Restraint]	c5ar_human	C293S  [Orientation Restraint]	c5ar_human	P113A
c5ar_human	P170A  [Orientation Restraint]	c5ar_human	C285S  [Orientation Restraint]	ssr1_human	L134M
ssr1_human	S135T	ssr1_human	V139I  [Orientation Restraint]	ssr1_human	S308V  [Orientation Restraint]
ssr1_human	M285L  [Orientation Restraint]	ssr1_human	F195Y  [Orientation Restraint]	nk2r_human	H267F  [Orientation Restraint]
nk2r_human	F293A  [Orientation Restraint]	nk2r_human	F270A  [Orientation Restraint]	nk2r_human	F112A  [Orientation Restraint]
nk2r_human	T115A  [Orientation Restraint]	nk2r_human	H267L  [Orientation Restraint]	nk2r_human	S170A  [Orientation Restraint]
5ht2a_human	D120N  [Orientation Restraint]	5ht2a_human	D120A  [Orientation Restraint]	agtra_rat	F28Y
agtra_rat	V29A	agtra_rat	I193L	agtra_rat	L195I
agtra_rat	D278E	agtra_rat	D281E	agtra_rat	I276L
agtra_rat	I279L	agtra_rat	S277T	agtra_rat	T282S
agtra_rat	V280I	gasr_human	V63I  [Orientation Restraint]	gasr_human	I75V  [Orientation Restraint]
gasr_human	M67L  [Orientation Restraint]	gasr_human	A104C  [Orientation Restraint]	gasr_human	L184T  [Orientation Restraint]
gasr_human	L185I  [Orientation Restraint]	gasr_human	I229L  [Orientation Restraint]	gasr_human	F228L  [Orientation Restraint]
gasr_human	A235V  [Orientation Restraint]	gasr_human	V232L  [Orientation Restraint]	gasr_human	L336I  [Orientation Restraint]
gasr_human	Y350F  [Orientation Restraint]	gasr_human	H394N	gasr_human	V389I  [Orientation Restraint]
gasr_human	V63L  [Orientation Restraint]	gasr_human	A91I	gasr_human	A149S  [Orientation Restraint]
gasr_human	A235M  [Orientation Restraint]	gasr_human	I229T  [Orientation Restraint]	gasr_human	L225I  [Orientation Restraint]
gasr_human	L347M  [Orientation Restraint]	gasr_human	T354A	gasr_human	A381T  [Orientation Restraint]
5ht1a_human	D82N  [Orientation Restraint]	5ht1a_human	D116N  [Orientation Restraint]	5ht1a_human	T200A  [Orientation Restraint]
5ht1a_human	D82A  [Orientation Restraint]	5ht1a_human	S391A  [Orientation Restraint]	5ht1a_human	N396V  [Orientation Restraint]
5ht1a_human	N396Q  [Orientation Restraint]	5ht1a_human	N396A  [Orientation Restraint]	5ht1a_human	N396F  [Orientation Restraint]
5ht2a_human	S242A  [Orientation Restraint]	ada2a_human	D113N  [Orientation Restraint]	ada2a_human	F412N  [Orientation Restraint]
adrb2_human	C327S	adrb2_human	D79N  [Orientation Restraint]	adrb2_human	T164I  [Orientation Restraint]
adrb2_mesau	C327V	adrb2_mesau	E107A	drd1_human	S199A  [Orientation Restraint]

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Reference:

Jian Zhang and Yang Zhang, GPCRRD: G protein-coupled receptor spatial restraint database for 3-D structure modeling and function annotation, Bioinformatics, 26:3004-3005 (2010).