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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
drd2_human Y416C  [Orientation Restraint] drd2_human N418C  [Orientation Restraint] drd2_human S419C  [Orientation Restraint]
drd2_human N422C  [Orientation Restraint] drd2_human I425C  [Orientation Restraint] drd2_human Y426C  [Orientation Restraint]
drd2_human F429C  [Orientation Restraint] v2r_human Y205C acthr_human D107N  [Orientation Restraint]
acthr_human V45I  [Orientation Restraint] opsd_bovin L226C opsd_bovin F228C
opsd_bovin T229C opsd_bovin V230C opsd_bovin M253C
ptafr_human F97G  [Orientation Restraint] bkrb2_human C184S  [Orientation Restraint] ada1b_mesau F202G
adrb2_human S165A  [Orientation Restraint] ada1a_human F86M agtra_rat D278A
agtra_rat D278K agtra_rat D281A agtra_rat D281K
lshr_human L607 lshr_human L608 lshr_human M571
lshr_human T627 lshr_human V606 drd1_human I205A  [Orientation Restraint]
drd1_human I205Y  [Orientation Restraint] drd1_human L286A  [Orientation Restraint] drd1_human L286Y  [Orientation Restraint]
aa2ar_human Q89A  [Orientation Restraint] aa2ar_human S90A  [Orientation Restraint] aa2ar_human S277C  [Orientation Restraint]
aa2ar_human S281N  [Orientation Restraint] aa2ar_human Q89N  [Orientation Restraint] aa2ar_human Q89S  [Orientation Restraint]
aa2ar_human Q89L  [Orientation Restraint] aa2ar_human Q89H  [Orientation Restraint] aa2ar_human Q89R  [Orientation Restraint]
v2r_human L44P  [Orientation Restraint] v2r_human L44F  [Orientation Restraint] v2r_human W164S  [Orientation Restraint]
ada1d_human M156F adrb2_human R328 adrb2_human C327
adrb2_human E306 adrb2_human S329 adrb2_human I298
adrb2_mesau R328 adrb2_mesau C327 adrb2_mesau E306
adrb2_mesau I298 adrb2_mesau S329 lshr_rat T631
lshr_rat A364 lshr_rat R367 lshr_rat L366
lshr_rat F365 lshr_human I549 lshr_human K548
ednrb_rat I126 ednrb_rat K161 ednrb_rat Y102
fpr1_human V50 cckar_human A42V cnr1_human V188
cnr2_human Y190 adrb1_human A348 ednrb_human I103
ednra_human C177 ednra_human P228 aa1r_bovin L81
aa1r_bovin Y179 acm2_human A140 acm2_human G141
drd2_mouse M375 adrb3_human W178 adrb3_human W177
ada1a_human R166 ada1a_human P182 ada1a_human F297
ada1a_human T306 ada1a_human F86 glr_rat A228
glr_rat N175 glr_rat Q233 glr_rat I231
glr_rat M232 glr_rat T229 glr_rat Y176


Reference:

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