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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameD(1B) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD5
SynonymD(5) dopamine receptor
Dopamine D5 receptor
Gpcr1
D(1B) dopamine receptor
dopamine receptor 5
[ Show all ]
DiseaseSchizophrenia
Solid tumours
Length477
Amino acid sequenceMLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProtP21918
Protein Data BankN/A
GPCR-HGmod modelP21918
3D structure modelThis predicted structure model is from GPCR-EXP P21918.
BioLiPN/A
Therapeutic Target DatabaseT46828
ChEMBLCHEMBL1850
IUPHAR218
DrugBankBE0004889, BE0000145

Known ligands

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Total entries: 779
Page:  / 8 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
812D structureEticloprideC17H25ClN2O3340.8484 / 23.1Yes
992D structureAC1O8PYYC17H25ClN2O3340.8484 / 23.1Yes
10162D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
10602D structureCHEMBL2420770C15H17FN2S276.3734 / 03.2Yes
22572D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
24092D structureCHEMBL425069C27H28ClN5O3506.0036 / 14.3No
31542D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
34602D structureCHEMBL201177C21H24N2304.4371 / 14.6Yes
35762D structureCHEMBL238915C21H24ClN3O3S433.9515 / 03.6Yes
38952D structureCHEMBL239917C22H26ClN3O383.923 / 03.9Yes
39992D structureMLS000118160C20H18N4O3362.3896 / 13.2Yes
47202D structurecid_654562C19H20N4O2S368.4556 / 12.6Yes
53642D structureCHEMBL396560C21H24N2O320.4362 / 14.3Yes
53802D structureIndolo[2,3-b]quinoxalin-6-yl-acetic acid ethyl esterC18H15N3O2305.3374 / 03.2Yes
56762D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
4637182D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
71282D structureCHEMBL398813C23H25F3N4O430.4757 / 04.1Yes
84592D structureCHEMBL598105C26H23ClN2O414.9333 / 15.8No
97082D structureMLS000102793C20H15N3O4S2425.4778 / 13.5Yes
101752D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
107402D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
108772D structureCHEMBL3289645C19H22F3N3O365.47 / 04.0Yes
110162D structureCHEMBL201086C11H12O2176.2152 / 02.2Yes
111392D structureCHEMBL558364C17H19ClFNO307.7933 / 2N/AN/A
120222D structureCHEMBL517244C35H44N2O508.753 / 07.8No
128322D structureCHEMBL1940408C20H24ClFN2346.8743 / 05.3No
5533242D structureADTNC10H13NO2179.2193 / 31.4Yes
136982D structureBDBM86280C17H18BrNO2348.243 / 33.2Yes
138142D structureCHEMBL380330C19H23NO281.3992 / 04.1Yes
141642D structurecid_652353C14H14N4OS286.3535 / 22.8Yes
154842D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
4422842D structureCHEMBL3321789C22H25ClFNO2389.8954 / 14.8Yes
168862D structureGlemanserinC20H25NO295.4262 / 13.8Yes
192032D structureCHEMBL559164C20H22FNO311.43 / 04.5Yes
201952D structureimipramineC19H24N2280.4152 / 04.8Yes
5221492D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5222092D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
224832D structureCHEMBL238916C22H24F3N3O3S467.5078 / 03.8Yes
233552D structuresulpirideC15H23N3O4S341.4266 / 20.6Yes
240982D structureCHEMBL389559C20H25NO295.4262 / 14.5Yes
242192D structureCHEMBL382780C21H22N2O318.421 / 13.9Yes
260462D structureLISURIDEC20H26N4O338.4552 / 22.7Yes
260702D structureS-(-)-LisurideC20H26N4O338.4552 / 22.7Yes
260882D structureAC1L1H1TC20H26N4O338.4552 / 22.7Yes
261572D structureSMR000093497C18H21NO4315.3694 / 13.2Yes
262732D structureSMR000028039C20H18N2O4S382.4345 / 12.8Yes
270162D structureCHEMBL2420891C19H18Cl2N2S377.3273 / 05.6No
271902D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
273322D structureMLS000084541C13H15N9OS345.38510 / 21.5Yes
274882D structureCHEMBL2432063C19H29N271.4481 / 04.7Yes
285332D structureCHEMBL197796C24H33N5O2S455.6216 / 13.1Yes
4665012D structureJ3.522.165DC35H48N6O5632.8068 / 35.1No
291692D structureCHEMBL1086790C19H18N2274.3671 / 13.6Yes
294132D structureCHEMBL1940420C18H22FN3O315.3925 / 03.7Yes
295712D structureCHEMBL3289653C21H23ClN2O354.8783 / 05.2No
298222D structureCHEMBL2420772C15H16Cl2N2S327.2673 / 04.3Yes
306872D structureMLS000101323C15H17N3OS287.3813 / 13.6Yes
321182D structureaspirinC9H8O4180.1594 / 11.2Yes
323152D structuren-PropylapomorphineC19H21NO2295.3823 / 23.2Yes
323172D structureN-n-PropylnorapomorphineC19H21NO2295.3823 / 23.2Yes
330492D structurememantineC12H21N179.3071 / 13.3Yes
338932D structureCHEMBL556194C16H17ClFNO293.7663 / 2N/AN/A
352812D structureCHEMBL201525C18H21N251.3731 / 04.6Yes
353432D structureCHEMBL600083C19H19BrClNO392.7212 / 15.1No
385382D structureSMR000111657C17H18N2O266.3442 / 13.0Yes
402852D structureAripiprazoleC23H27Cl2N3O2448.3884 / 14.6Yes
407292D structureSMR000103840C20H19F3N4O2404.3937 / 03.5Yes
5483592D structureCHEMBL3957865C21H23F2N3355.4334 / 05.1No
424722D structureCHEMBL2432039C20H23N277.4111 / 12.7Yes
5585882D structureCHEMBL464811C32H38ClN5O544.145 / 15.8No
457712D structure23981-80-8C14H14O3230.2633 / 13.3Yes
459962D structurecid_657898C16H16N4O2S328.397 / 22.3Yes
460052D structureCHEMBL2420779C18H23N3O297.4024 / 02.6Yes
460712D structureCHEMBL437888C19H26N2282.4311 / 14.2Yes
461122D structureCHEMBL389357C20H25NO295.4262 / 04.5Yes
472762D structureCHEMBL3289643C21H23ClN2O354.8783 / 04.3Yes
474912D structureCHEMBL2432051C21H27NO3341.4514 / 13.3Yes
5484402D structureCHEMBL3983633C23H26F2N2O384.4714 / 15.2No
477452D structureCHEMBL328866C23H26ClN3O3427.9294 / 23.2Yes
489782D structureCHEMBL240996C23H26F3N3O417.4766 / 04.2Yes
495622D structureCHEMBL394777C19H20ClNO313.8252 / 04.5Yes
500372D structure3-hydroxytyraminium chlorideC8H12ClNO2189.6393 / 3N/AN/A
4437552D structureML398C19H22ClNO315.8412 / 04.4Yes
4437572D structureCHEMBL3335540C19H22ClNO315.8412 / 04.4Yes
520232D structure1-BenzylpyrrolidineC11H15N161.2481 / 02.2Yes
529082D structureCHEMBL1829958C12H9BrN4O305.1354 / 32.3Yes
531732D structureCHEMBL604127C20H19ClN2O338.8353 / 14.2Yes
536682D structureCHEMBL1087301C20H22N2290.411 / 14.3Yes
537782D structure{4-[(3-fluorophenyl)methoxy]phenyl}methanamine hydrochlorideC14H15ClFNO267.7283 / 2N/AN/A
538242D structureCHEMBL596179C18H21NO267.3722 / 13.7Yes
540562D structureST-1535C12H16N8272.3166 / 11.8Yes
542182D structureMLS000052086C19H16N4S332.4254 / 04.6Yes
544842D structureCHEMBL540613C19H20FNO297.3733 / 14.2Yes
555532D structure6-Methoxy-1-phenyl-1H-benzimidazoleC14H12N2O224.2632 / 03.1Yes
556522D structurefenfluramineC12H16F3N231.2624 / 13.4Yes
563162D structureCHEMBL2205833C17H18N2O266.3443 / 11.3Yes
568612D structureCHEMBL604316C20H20ClNO2341.8353 / 13.9Yes
5485412D structureAripiprazole lauroxilC36H51Cl2N3O4660.7216 / 010.0No
572142D structureCHEMBL212912C25H23Cl2N5O480.3934 / 15.0Yes
581042D structurecinnarizineC26H28N2368.5242 / 05.8No

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