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Ligand

NameCHEMBL355202
Molecular formulaC25H25N3O
IUPAC name8-[(1R)-1,2-dihydroacenaphthylen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight383.495
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.5
Synonyms(R)-Ro 65-6570
(R)-Ro65-6570
1-Phenyl-8-[(1R)-acenaphthen-1-yl]-1,3,8-triazaspiro[4.5]decan-4-one
8-(R)-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
8-[(1R)-1,2-dihydroacenaphthylen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
[ Show all ]
Inchi KeyBBOAHBVXCYBKLC-JOCHJYFZSA-N
Inchi IDInChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)/t22-/m1/s1
PubChem CID15512229
ChEMBLCHEMBL355202
IUPHAR8864
BindingDB50087698
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 18
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
196685-hydroxytryptamine receptor 1DP28221HTR1DHomo sapiens (Human)377
196665-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
196565-hydroxytryptamine receptor 2CP28335HTR2CHomo sapiens (Human)458
196615-hydroxytryptamine receptor 6P50406HTR6Homo sapiens (Human)440
196605-hydroxytryptamine receptor 7P34969HTR7Homo sapiens (Human)479
19673Corticotropin-releasing factor receptor 1P35353Crhr1Rattus norvegicus (Rat)415
19664D(1A) dopamine receptorQ61616Drd1Mus musculus (Mouse)446
19667D(2) dopamine receptorP14416DRD2Homo sapiens (Human)443
19671D(3) dopamine receptorP35462DRD3Homo sapiens (Human)400
19670D(4) dopamine receptorP21917DRD4Homo sapiens (Human)467
19669Delta-type opioid receptorP41143OPRD1Homo sapiens (Human)372
19672Delta-type opioid receptorP33533Oprd1Rattus norvegicus (Rat)372
19663Kappa-type opioid receptorP41145OPRK1Homo sapiens (Human)380
19665Kappa-type opioid receptorP34975Oprk1Rattus norvegicus (Rat)380
19658Mu-type opioid receptorP33535Oprm1Rattus norvegicus (Rat)398
19662Mu-type opioid receptorP35372OPRM1Homo sapiens (Human)400
19657Nociceptin receptorP35370Oprl1Rattus norvegicus (Rat)367
19659Nociceptin receptorP41146OPRL1Homo sapiens (Human)370

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