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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameAlpha-1A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA1A
SynonymAlpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Alpha-1A adrenoceptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
UniProtP18130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4892
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 288
Page:  / 3 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
16352D structureCHEMBL1259079C26H28N2S400.5843 / 05.7No
42192D structureCHEMBL25984C15H23NO233.3552 / 03.8Yes
49752D structureCHEMBL50188C25H36N2O4428.5735 / 04.2Yes
55482D structureCHEMBL50722C25H36N2O5444.5726 / 04.3Yes
55602D structureCHEMBL18270C11H14N2174.2472 / 01.1Yes
59202D structureCHEMBL50722C27H38N2O9534.60610 / 2N/ANo
68392D structureCHEMBL1259231C23H26N4S390.5494 / 03.7Yes
81182D structureCHEMBL317333C26H24FN5425.5115 / 04.0Yes
83132D structureCHEMBL1259080C27H30N2S414.6113 / 06.1No
100492D structureAbanoquilC22H25N3O4395.4597 / 13.4Yes
118062D structureCHEMBL54266C23H32N2O4S432.5796 / 14.3Yes
136492D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
178942D structureBmy-7378C22H31N3O3385.5085 / 02.8Yes
196092D structureCHEMBL327116C15H19N3O2S305.3964 / 22.1Yes
215982D structureCHEMBL14213C26H28N4O3S476.5956 / 04.1Yes
216932D structureCHEMBL89916C26H39N5O2453.6316 / 14.4Yes
265612D structureRauwolscineC21H26N2O3354.454 / 22.9Yes
265882D structureYohimbineC21H26N2O3354.454 / 22.9Yes
288442D structure1-(3,5-dichloropyridin-2-yl)piperazineC9H11Cl2N3232.1083 / 11.9Yes
328642D structureCHEMBL1203301C22H26N4O5S458.5339 / 21.8Yes
332872D structureCHEMBL176365C20H21N3303.4092 / 02.2Yes
338542D structureCHEMBL2325928C24H25FN4388.493 / 04.3Yes
378382D structureCHEMBL327527C27H30FN7O487.5835 / 13.2Yes
392142D structureCHEMBL92901C22H31N5O2397.5236 / 23.3Yes
413152D structureCHEMBL60318C20H22FN3OS371.4745 / 03.9Yes
441492D structureCHEMBL1259158C25H33N3OS423.6194 / 14.2Yes
5372492D structureDEXMEDETOMIDINEC13H16N2200.2851 / 13.1Yes
546102D structureCHEMBL48925C25H34N2O4426.5575 / 14.6Yes
567002D structurecisaprideC23H29ClFN3O4465.957 / 23.4Yes
571882D structureCID 44350012C17H25N5O4363.4187 / 3N/AN/A
574062D structureCHEMBL298534C24H31FN2O3414.5215 / 14.7Yes
592622D structureCHEMBL64167C20H23N3OS353.4844 / 03.8Yes
622132D structurespiperoneC23H26FN3O2395.4785 / 13.0Yes
623162D structureCHEMBL51888C22H30N2O4S418.5526 / 13.9Yes
625122D structureCHEMBL52438C19H25NO283.4152 / 05.1No
630832D structureCHEMBL11592C26H38N2O4442.65 / 04.6Yes
644142D structureCHEMBL24619C30H34N4O6546.62410 / 15.0No
669622D structureTAMSULOSINC20H28N2O5S408.5137 / 22.7Yes
683452D structureCHEMBL1203301C22H27ClN4O5S494.9919 / 3N/AN/A
689422D structureCHEMBL301060C28H40N2O8532.6349 / 2N/ANo
693952D structureCHEMBL328187C27H30FN7O487.5835 / 12.9Yes
699502D structureCHEMBL93923C28H31FN6O486.5954 / 13.4Yes
711322D structureCHEMBL47471C16H18ClN3287.7913 / 03.2Yes
719372D structureCHEMBL17926C11H13ClN2208.6892 / 01.7Yes
727432D structureCHEMBL59741C20H20F3N3OS407.4557 / 14.5Yes
765892D structure(R)-zacoprideC15H20ClN3O2309.7944 / 21.7Yes
772612D structureSDZ-205557C14H21ClN2O3300.7835 / 13.2Yes
777092D structureCHEMBL91876C24H33N5O2423.5616 / 13.6Yes
777762D structureCHEMBL1259188C27H31FN8O502.5986 / 13.6No
794622D structureCHEMBL156283C10H15N3177.2512 / 11.0Yes
795102D structureCHEMBL368475C20H21F3N2S378.4575 / 04.2Yes
827222D structure87394-57-8C10H14ClN3211.6933 / 01.7Yes
853762D structure87394-63-6C10H12F3N3231.2226 / 11.5Yes
878852D structureCHEMBL1259062C26H28N2S400.5843 / 05.7No
880132D structureCHEMBL420997C25H25FN6428.5155 / 03.8Yes
880842D structureCHEMBL296395C22H24N2O4380.4445 / 12.9Yes
882192D structureCHEMBL1259042C23H24N4S388.5335 / 03.6Yes
882702D structureCHEMBL50993C25H36N2O3412.5744 / 04.6Yes
929832D structureCHEMBL300735C24H34N2O4S446.6066 / 14.6Yes
942532D structureCHEMBL330060C23H32N4O2396.5355 / 13.9Yes
958152D structureCHEMBL338704C11H14BrN5296.1724 / 02.0Yes
958762D structureCHEMBL538537C12H18ClN5267.7614 / 2N/AN/A
5384112D structureclonidineC9H9Cl2N3230.0921 / 21.6Yes
993292D structureCHEMBL368413C19H22N2278.3991 / 02.5Yes
1016342D structure5-Meo-dpacC16H25NO2263.3813 / 03.8Yes
1020882D structureCHEMBL91093C26H39N5O2453.6316 / 14.9Yes
1084002D structureCHEMBL299007C10H14ClN3211.6933 / 11.6Yes
1085952D structureWB-4101C19H23NO5345.3956 / 12.9Yes
1091322D structureSERTINDOLEC24H26ClFN4O440.9473 / 14.1Yes
1093752D structure1-(2-Pyridyl)piperazineC9H13N3163.2243 / 10.7Yes
1123542D structureCHEMBL285010C14H19NO2233.3113 / 02.5Yes
1130682D structureCHEMBL13735C19H22N4O3S386.476 / 12.2Yes
1157302D structure5-MethylurapidilC21H31N5O3401.5116 / 11.9Yes
1177702D structure1-(3-chloropyridin-2-yl)piperazineC9H12ClN3197.6663 / 11.3Yes
1183122D structureA-119637C25H26N4O3S462.5686 / 13.9Yes
1206622D structureCHEMBL54089C26H30N2O8498.5329 / 2N/AN/A
1208312D structureIDAZOXANC11H12N2O2204.2293 / 10.7Yes
1211402D structure1-(3-fluoropyridin-2-yl)piperazineC9H12FN3181.2144 / 10.8Yes
1215442D structureCHEMBL88512C20H27N5O2369.4696 / 22.6Yes
1216722D structureCHEMBL294730C22H27N3O2S397.5375 / 04.1Yes
1225832D structure1-(3-nitropyridin-2-yl)piperazineC9H12N4O2208.2215 / 10.5Yes
1252782D structureCHEMBL178376C20H19N3301.3932 / 02.5Yes
1313422D structureprazosinC19H21N5O4383.4088 / 12.0Yes
5614332D structureCHEMBL307364C10H11N5O217.2323 / 40.3Yes
1339502D structureCHEMBL346492C15H17NS243.3682 / 03.7Yes
1360692D structureCHEMBL59823C24H31N3O3409.535 / 03.6Yes
1405072D structureCHEMBL2325931C24H24N4368.4843 / 03.7Yes
1407332D structureCHEMBL52396C25H30N2O4422.5255 / 04.3Yes
1420282D structureCHEMBL88820C23H30N4O3410.5185 / 12.6Yes
1420532D structureCHEMBL61819C23H29N3O2S411.5645 / 04.4Yes
1429192D structure1',2',3',6'-Tetrahydro-[2,4']bipyridinylC10H12N2160.222 / 10.6Yes
1430132D structureCHEMBL17605C11H14N2174.2472 / 01.1Yes
1431472D structureCHEMBL545198C23H26N2O4394.4715 / 03.6Yes
1471822D structureCHEMBL92109C23H33N5O395.5515 / 13.9Yes
1484182D structureCHEMBL346016C11H15NS193.3082 / 02.4Yes
1502882D structureCHEMBL366388C24H29FN2O380.5074 / 04.1Yes
1529212D structureCHEMBL51985C27H41N2O4+457.6354 / 04.6Yes
1531202D structureCHEMBL545198C23H27ClN2O4430.9295 / 1N/AN/A
1535412D structureCHEMBL1259005C24H26N2S2406.6064 / 05.4No
1593802D structureCHEMBL1259113C20H25N3S339.5014 / 12.6Yes

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