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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 7
SpeciesHomo sapiens (Human)
GeneGRM7
SynonymGLUR7
glutamate receptor
GPRC1G
mGlu7 receptor
mGlu7a receptor
[ Show all ]
DiseaseN/A
Length915
Amino acid sequenceMVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProtQ14831
Protein Data Bank5c5c, 3mq4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5c5c.
BioLiPBL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3777
IUPHAR295
DrugBankBE0000834

Known ligands

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Total entries: 127
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
82702D structureCHEMBL2208408C15H15ClN2O3S338.8064 / 12.6Yes
104032D structureCHEMBL2426616C14H14N2O2S274.3384 / 02.3Yes
5217692D structureCHEMBL2312685C8H16N2O4204.2266 / 4-6.8Yes
133252D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
203152D structureCHEMBL319279C28H27NO5457.5266 / 32.1Yes
4653752D structureAC1N2AWGC24H24N2O4S436.5265 / 14.1Yes
5533572D structureLSP4-2022C13H18NO8P347.269 / 5-3.8Yes
4666892D structureCHEMBL3560146C24H24N2O5420.4655 / 13.5Yes
357902D structureBDBM50388941C16H13N3O3295.2985 / 11.4Yes
366832D structureCID 57689797C3H8NO6P185.0726 / 3-4.5Yes
366922D structuredl-O-PhosphoserineC3H8NO6P185.0727 / 4-5.1Yes
4674922D structureCHEMBL3605296C20H17N5O3375.3886 / 12.1Yes
5228732D structureCHEMBL3746457C18H15FN4O2338.3425 / 02.2Yes
5534682D structureADX-71743C17H19NO2269.3443 / 03.8Yes
4692632D structureCHEMBL3628115C19H12ClN3O4381.7725 / 12.6Yes
531322D structureCHEMBL1688377C18H25N3OS331.4784 / 03.3Yes
557092D structureCHEMBL1830707C14H13N5S283.3535 / 22.8Yes
4699522D structureCHEMBL3628112C20H12Cl2N2O4415.2264 / 14.3Yes
572762D structure2-amino-4-phosphonobutanoic acidC4H10NO5P183.16 / 4-5.5Yes
572902D structureL-AP4C4H10NO5P183.16 / 4-5.5Yes
611582D structureCHEMBL334014C8H10FNO4203.1696 / 3-3.2Yes
628562D structureCHEMBL392419C11H14NO5P271.2096 / 4-3.3Yes
628682D structureCHEMBL392420C11H14NO5P271.2096 / 4-3.3Yes
5535652D structure(S)-MCPGC10H11NO4209.2015 / 3-2.0Yes
4710162D structureCHEMBL3561387C23H23F2NO3S431.4986 / 05.9No
5536002D structureMLS001173561C28H28N2392.5462 / 25.7No
706812D structureLY307452C21H25NO4355.4345 / 31.4Yes
792062D structureBDBM86213C13H13NO4247.255 / 01.5Yes
806512D structureCHEMBL1783985C15H25NO235.3711 / 03.4Yes
4733252D structureCHEMBL3561819C24H25NO3S407.5284 / 05.2No
894712D structureCPCCOEtC13H13NO4247.255 / 11.9Yes
5537152D structureMSOPPEC10H14NO6P275.1977 / 3-2.6Yes
5241962D structureCHEMBL2312684C7H14N2O4190.1996 / 4-6.3Yes
4747662D structureCHEMBL3560922C24H23NO6421.4496 / 04.1Yes
964702D structure2-(m-tolylethynyl)pyrimidineC13H10N2194.2372 / 02.6Yes
992232D structureCHEMBL333519C8H10FNO4203.1696 / 3-3.0Yes
5537652D structureMSOPC4H10NO6P199.0997 / 4-5.0Yes
5537782D structureD0N9UZC12H13N5O6323.2658 / 5-4.7Yes
1092952D structure(2S,1'S,2'S)-2-(carboxycyclopropyl)glycineC6H9NO4159.1415 / 3-3.4Yes
4770852D structureCHEMBL3628113C20H12ClFN2O4398.7745 / 13.8Yes
5248762D structureCHEMBL3804846C22H14F2N2O2376.3635 / 13.9Yes
4463562D structureCTK0H1302C6H9NO4159.1415 / 3-3.7Yes
4463652D structureCHEMBL3347670C6H9NO4159.1415 / 3-3.7Yes
1198102D structureCHEMBL319732C26H31NO5437.5366 / 32.9Yes
5538802D structureMAP4C5H12NO5P197.1276 / 4-4.6Yes
1202252D structureCHEBI:75204C8H9NO4183.1634 / 3-1.8Yes
1271102D structureCHEMBL1830711C13H12N6S284.3416 / 22.1Yes
4805982D structureAC1P03JTC18H22N2O2S330.4463 / 12.9Yes
1511482D structureCHEMBL420262C29H37NO5479.6176 / 34.5Yes
4821962D structureCHEMBL3561545C22H21FN2O2S396.484 / 14.3Yes
1582992D structure(RS)-PPGC8H10NO5P231.1446 / 4-3.7Yes
4825822D structureCHEMBL3561788C20H21N3O2S2399.5275 / 14.0Yes
5541252D structureMCCG-IC7H11NO4173.1685 / 3-3.3Yes
1675532D structureMGS-0028C8H8FNO5217.1527 / 3-4.2Yes
1819592D structureCHEMBL197976C5H10NO5P195.1116 / 4-4.7Yes
1819652D structureCHEMBL199626C5H10NO5P195.1116 / 4-4.7Yes
1819742D structureCHEMBL442076C5H10NO5P195.1116 / 4-4.7Yes
5267342D structureCHEMBL2312682C8H12N2O4200.1946 / 3-3.4Yes
4863532D structureCHEMBL3561539C22H21F2NO3S417.4716 / 05.9No
5633622D structureSIB 1757C12H11N3O213.244 / 13.0Yes
1927062D structureCHEMBL1682820C16H14O3254.2853 / 02.8Yes
1956622D structureCHEMBL40123C19H21NO4327.385 / 30.3Yes
2010232D structureDcg-IVC7H9NO6203.157 / 4-4.3Yes
4883562D structureCHEMBL3560239C24H25NO4S423.5275 / 04.8Yes
4883622D structureMLS000335684C22H21FN2O2S396.484 / 14.3Yes
2063612D structureCHEMBL1830698C13H11N5S269.3265 / 22.4Yes
2085472D structure7-(benzyloxy)-2,3-dihydro-4H-chromen-4-oneC16H14O3254.2853 / 02.8Yes
4897042D structureAC1N0VGZC21H26N2O3S386.514 / 12.9Yes
4900162D structureCHEMBL3561870C25H26N2O4S450.5535 / 04.3Yes
2186762D structureCID 70682300C16H13N3O3295.2985 / 21.8Yes
2189472D structureCHEMBL439775C22H23NO5381.4286 / 30.7Yes
2216392D structureMPEPC14H11N193.2491 / 03.3Yes
4505942D structureCHEMBL3401195C19H16FN3O2337.3544 / 03.1Yes
2355862D structureCHEMBL315268C8H12N2O4200.1945 / 3-2.9Yes
4926262D structureCHEMBL3560612C23H22F2N2O4428.4366 / 14.6Yes
5545372D structureMPPGC9H12NO5P245.1716 / 4-3.5Yes
2559682D structureAZD-6538C15H6FN5O291.2457 / 02.0Yes
5292402D structureCHEMBL3747116C19H16FN3O2337.3544 / 03.2Yes
2732102D structureUNII-J5PMS063XXC19H23ClN4O358.874 / 14.0Yes
2740932D structureCHEMBL8839C7H9NO4S203.2126 / 3-3.5Yes
2741002D structureCHEMBL88999C7H9NO4S203.2126 / 3-3.5Yes
4977812D structureCHEMBL3560758C23H23F2NO2S415.4995 / 06.3No
5296772D structureCHEMBL479797C7H11NO6205.1667 / 4-4.0Yes
2900962D structureCHEMBL505105C13H11N3209.2523 / 12.5Yes
2910562D structureCHEMBL34880C5H10NO5P195.1116 / 4-5.0Yes
2910572D structureCHEMBL229697C5H10NO5P195.1116 / 4-5.0Yes
2910642D structureCHEMBL227288C5H10NO5P195.1116 / 4-5.0Yes
2910682D structureCHEMBL287703C5H10NO5P195.1116 / 4-5.0Yes
2923862D structureAZD 9272C14H6F2N4O284.2267 / 02.3Yes
2954572D structureCHEMBL1672539C21H19Cl2N5412.3184 / 15.3No
3016092D structureCHEMBL205571C16H11Cl2N3S348.2454 / 04.9Yes
3030222D structureCHEMBL97200C24H27NO5409.4826 / 31.5Yes
3059452D structureCHEMBL329920C25H29NO5423.5096 / 32.4Yes
5007772D structureCHEMBL3633943C15H17N3O2271.323 / 01.5Yes
4540472D structureCHEMBL3401177C19H14FN3O2335.3384 / 03.2Yes
3153822D structureSIB 1893C14H13N195.2651 / 03.6Yes
3184142D structureCHEMBL95868C24H27NO5409.4826 / 31.8Yes
3247572D structureML332C14H16ClF3N2O3S384.7987 / 12.7Yes
3268922D structureCHEMBL2426621C15H11NOS253.3193 / 03.5Yes
3463222D structureMLS000530551C15H14Cl2N2O3S373.2484 / 13.2Yes

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