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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesRattus norvegicus (Rat)
GeneHtr6
Synonym5-HT-6
5-HT6
5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Serotonin receptor 6
[ Show all ]
DiseaseN/A for non-human GPCRs
Length436
Amino acid sequenceMVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProtP31388
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3372
IUPHAR11
DrugBankN/A

Known ligands

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Total entries: 174
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
92902D structureCHEMBL1949768C20H24ClNO4S409.9255 / 2N/AN/A
110582D structuretryptamineC10H12N2160.221 / 21.6Yes
135492D structureN-MethylserotoninC11H14N2O190.2462 / 30.7Yes
201832D structureimipramineC19H24N2280.4152 / 04.8Yes
209372D structureSB-258585C18H22IN3O3S487.3566 / 13.0Yes
212342D structure(RS)-PPCCC24H29NO3379.54 / 13.5Yes
223222D structureCHEMBL363466C20H25NO2311.4253 / 04.2Yes
233602D structuresulpirideC15H23N3O4S341.4266 / 20.6Yes
5533872D structureLISURIDEC20H26N4O338.4552 / 22.7Yes
260592D structureS-(-)-LisurideC20H26N4O338.4552 / 22.7Yes
270422D structureSB-357134C17H18Br2FN3O3S523.2157 / 23.4No
344982D structureCHEMBL1935600C20H18FNO4S387.4256 / 12.5Yes
5226012D structureCHEMBL3797434C26H30N6O3474.5656 / 13.2Yes
384082D structureCHEMBL1949765C18H19NO3S329.4144 / 12.6Yes
403032D structureAripiprazoleC23H27Cl2N3O2448.3884 / 14.6Yes
468102D structureCHEMBL1949760C17H16FNO3S333.3775 / 12.4Yes
5535332D structureNSC409663C35H41N5O5611.7436 / 33.3No
5232632D structureCHEMBL3797890C28H33N3O2443.5912 / 25.6No
5232972D structureCHEMBL3797957C24H25ClN6O448.9554 / 13.9Yes
605902D structureCHEMBL1949930C21H25NO5S403.4936 / 13.0Yes
622202D structurespiperoneC23H26FN3O2395.4785 / 13.0Yes
624042D structureMELPERONEC16H22FNO263.3563 / 03.3Yes
5234922D structureCHEMBL3798243C24H32N6O420.5614 / 14.0Yes
682812D structureCHEMBL1935598C20H20FNO4S389.4416 / 12.7Yes
5536202D structureS-16924C22H24FNO4385.4356 / 03.4Yes
761272D structureCHEMBL1949773C17H15F2NO3S351.3686 / 12.5Yes
838932D structureKetanserinC22H22FN3O3395.4345 / 12.6Yes
864792D structure4'-AminopropiophenoneC9H11NO149.1932 / 11.7Yes
5537132D structurePAPPC19H22F3N3349.4016 / 14.0Yes
937302D structureclomipramineC19H23ClN2314.8572 / 05.2No
949052D structurethiothixeneC23H29N3O2S2443.6246 / 03.8Yes
988542D structureCHEMBL1949764C17H16ClNO3S349.8294 / 12.9Yes
1054682D structureAC1L1JJRC21H27N3321.4682 / 13.9Yes
1056512D structureRemoxiprideC16H23BrN2O3371.2754 / 12.1Yes
1091422D structureSERTINDOLEC24H26ClFN4O440.9473 / 14.1Yes
1121572D structurezotepineC18H18ClNOS331.8583 / 04.8Yes
1161392D structureBufoteniumC13H19N2O+219.3081 / 21.2Yes
1170802D structureCHEMBL1935589C17H15NO3S313.3714 / 12.6Yes
1194462D structureCHEMBL313714C26H31FN6O462.5736 / 32.9Yes
5250682D structureCHEMBL3799903C26H31N3O4449.5514 / 23.5Yes
1228292D structureNAE-111C16H24N2O2276.383 / 12.6Yes
1257862D structureCHEMBL1949762C23H22ClNO3S427.9434 / 2N/AN/A
1266392D structureVolinanserinC22H28FNO3373.4685 / 13.9Yes
1285902D structureCHEMBL193400C18H17Cl2N3O2S410.3134 / 14.0Yes
1343712D structureCHEMBL1949761C17H16ClNO3S349.8294 / 12.9Yes
1357452D structureCHEMBL1949930C21H26ClNO5S439.9516 / 2N/AN/A
1363532D structureCHEMBL1935588C17H15NO3S313.3714 / 12.6Yes
1371072D structureCHEMBL1949762C23H21NO3S391.4854 / 13.9Yes
1481022D structureCHEMBL1744087C20H30N2O7S442.5279 / 2N/AN/A
1489612D structureRo 04-6790C12H16N6O2S308.368 / 41.7Yes
5258362D structureCHEMBL3800049C28H26ClN3O2471.9852 / 25.5No
5258562D structureCHEMBL3800065C25H26N6O3458.5226 / 13.1Yes
1522092D structureCYPROHEPTADINEC21H21N287.4061 / 04.7Yes
5540282D structureLergotrileC17H18ClN3299.8022 / 13.3Yes
1528022D structureLergotrile [USAN:INN]C17H18ClN3299.8022 / 13.3Yes
1540242D structureMesulergineC18H26N4O2S362.4925 / 11.4Yes
1553022D structureDimebolinC21H25N3319.4522 / 03.5Yes
1593352D structure5-METHOXYTRYPTAMINEC11H14N2O190.2462 / 20.5Yes
1603442D structureritanserinC27H25F2N3OS477.5746 / 05.2No
1641732D structureClothiapineC18H18ClN3S343.8733 / 03.6Yes
1703752D structureCHEMBL1949763C17H17ClFNO3S369.8355 / 2N/AN/A
5263592D structureCHEMBL3798364C24H26BrN3O2468.3952 / 24.2Yes
1706552D structureCHEMBL1935597C19H16F3NO3S395.3967 / 13.7Yes
1711732D structure15532-75-9C11H13F3N2230.2345 / 12.3Yes
1717782D structurethioridazineC21H26N2S2370.5734 / 05.9No
1722202D structureMOLINDONEC16H24N2O2276.383 / 11.7Yes
1748642D structuremethysergideC21H27N3O2353.4663 / 22.3Yes
1756532D structuresumatriptanC14H21N3O2S295.4014 / 20.9Yes
1762362D structureCHEMBL1949772C18H20ClNO3S365.8724 / 2N/AN/A
1764262D structureamitriptylineC20H23N277.4111 / 05.0Yes
5265112D structureCHEMBL3798013C26H32N4O2432.5683 / 23.7Yes
4849022D structureCHEMBL365751C13H17ClN2236.7431 / 13.4Yes
1791522D structureCHEMBL515624C18H17ClN2O2S360.8563 / 13.7Yes
5630642D structureCHEMBL61861C19H19F3NO3-366.367 / 02.5Yes
1827422D structureCHEMBL1949761C17H17Cl2NO3S386.2874 / 2N/AN/A
1858932D structureChlorpromazine N-oxideC17H19ClN2OS334.8623 / 04.6Yes
1915742D structurehaloperidolC21H23ClFNO2375.8684 / 13.2Yes
1922122D structureSB-271046C20H22ClN3O3S2451.9847 / 24.2Yes
5542832D structuredihydroergotamineC33H37N5O5583.6896 / 32.4No
1971142D structureSCHEMBL12586671C33H37N5O5583.6896 / 32.4No
1986932D structureCGS 12066BC17H17F3N4334.3466 / 04.0Yes
5542912D structurealpha-methyl-5-HTC11H14N2O190.2462 / 30.6Yes
2027712D structurePENFLURIDOLC28H27ClF5NO523.9727 / 17.3No
2120072D structureRobalzotan BNAD 299 HCLC18H23FN2O2318.3924 / 12.8Yes
5276562D structureCHEMBL3799279C26H27ClN6O474.9934 / 14.7Yes
2163012D structureCHEMBL1935599C21H20FNO4S401.4526 / 12.9Yes
5277982D structureCHEMBL3797813C24H26ClN3O2423.9412 / 24.2Yes
2198312D structureN-MethyltryptamineC11H14N2174.2471 / 22.1Yes
2234792D structureCHEMBL1949764C17H17Cl2NO3S386.2874 / 2N/AN/A
2274612D structureAmperozideC23H29F2N3O401.5024 / 14.1Yes
5281262D structureCHEMBL3797430C28H32N6O468.6054 / 15.5No
2374212D structureFLUPERLAPINEC19H20FN3309.3883 / 02.9Yes
2387062D structuredoxepinC19H21NO279.3832 / 04.3Yes
2510732D structureCHEMBL1935601C21H20FNO4S401.4526 / 12.9Yes
5545272D structurebromocriptineC32H40BrN5O5654.6066 / 33.8No
2544692D structureSB-214111C18H22BrN3O3S440.3566 / 13.0Yes
2559442D structureDihydroergocryptineC32H43N5O5577.7266 / 33.1No
2563652D structureCHEMBL1949765C18H20ClNO3S365.8724 / 2N/AN/A
2601392D structurenortriptylineC19H21N263.3841 / 14.5Yes
2625082D structureFLUPHENAZINEC22H26F3N3OS437.5258 / 14.4Yes

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